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JOURNAL ARTICLE
Anne-Claire Billet, Thomas Thibault, Éric Liozon, Hubert De Boysson, Laurent Perard, Olivier Espitia, Aurélie Daumas, Quentin Gomes De Pinho, Cécile-Audrey Durel, Arnaud Hot, Boris Bienvenu, Sébastien Humbert, Claude Bachmeyer, Sabine Mainbourg, Thomas Sené, Hervé Devilliers, Bastien Durand Bailloud, Hélène Greigert, Alexandre Cochet, Bernard Bonnotte, Jean-Louis Alberini, Maxime Samson
OBJECTIVES: To evaluate the ability of 18 FDG PET/CT, at diagnosis of giant cell arteritis (GCA) and during follow-up, to predict occurrence of relapse in large-vessel GCA (LV-GCA). METHODS: We conducted a retrospective study using the French Study Group for Large-Vessel Vasculitis (GEFA) network. Data from patients with LV-GCA diagnosed by PET/CT and who had PET/CT in the following year were collected. For each PET/CT, PET vascular activity score (PETVAS) and total vascular score (TVS) were assessed, and their ability to predict the occurrence of subsequent relapse was assessed...
April 15, 2024: European Journal of Internal Medicine
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JOURNAL ARTICLE
Sonja C Mansfield Smith, Mustafa R Al-Hashimi, Colin D Jones, Chetan B Mukhtyar
BACKGROUND: We present the largest study of the frequency and nature of visual complications in a cohort of 350 patients consecutively diagnosed with giant cell arteritis (GCA). METHODS: All individuals were assessed using structured forms and diagnosed using imaging or biopsy. A binary logistic regression model was used to analyse data for predicting visual loss. RESULTS: Visual symptoms occurred in 101 (28.9%) patients, with visual loss in one or both eyes in 48 (13...
May 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
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JOURNAL ARTICLE
Wong Nee Ling, Stuart Carter
No abstract text is available yet for this article.
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#24
REVIEW
Yuki Sato, Maria Tada, Jorg J Goronzy, Cornelia M Weyand
Giant cell arteritis (GCA) is a prototypic autoimmune disease with a highly selective tissue tropism for medium and large arteries. Extravascular GCA manifests with intense systemic inflammation and polymyalgia rheumatica; vascular GCA results in vessel wall damage and stenosis, causing tissue ischemia. Typical granulomatous infiltrates in affected arteries are composed of CD4+ T cells and hyperactivated macrophages, signifying the involvement of the innate and adaptive immune system. Lesional CD4+ T cells undergo antigen-dependent clonal expansion, but antigen-nonspecific pathways ultimately control the intensity and duration of pathogenic immunity...
April 9, 2024: Best Practice & Research. Clinical Rheumatology
#25
JOURNAL ARTICLE
Pavlos Stamatis, Moman Aladdin Mohammad, Karl Gisslander, Peter A Merkel, Martin Englund, Carl Turesson, David Erlinge, Aladdin J Mohammad
OBJECTIVES: To determine the incidence rate (IR) of myocardial infarction (MI), relative risk of MI, and impact of incident MI on mortality in individuals with biopsy-confirmed giant cell arteritis (GCA). METHODS: MIs in individuals diagnosed with GCA 1998-2016 in Skåne, Sweden were identified by searching the SWEDEHEART register, a record of all patients receiving care for MI in a coronary care unit (CCU). The regional diagnosis database, with subsequent case review, identified GCA patients receiving care for MI outside of a CCU...
April 10, 2024: RMD Open
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JOURNAL ARTICLE
Marieke van Nieuwland, Edgar M Colin, Marloes Vermeer, Nils R L Wagenaar, Onno D Vijlbrief, Jordy K van Zandwijk, Riemer H J A Slart, Hendrik Koffijberg, Erik Groot Jebbink, Kornelis S M van der Geest, Elisabeth Brouwer, Dennis Boumans, Celina Alves
OBJECTIVES: This study directly compares diagnostic performance of Colour Duplex Ultrasound (CDUS), Fluor-18-deoxyglucose Positron Emission Tomography Computed Tomography (FDG-PET/CT) and Magnetic Resonance Imaging (MRI) in patients suspected of giant cell arteritis (GCA). METHODS: Patients with suspected GCA were included in a nested-case control pilot study. CDUS, whole body FDG-PET/CT and cranial MRI were performed within 5 working days after initial clinical evaluation...
April 10, 2024: Rheumatology
#27
JOURNAL ARTICLE
Thomas Ness, Bernhard Nölle
Giant cell arteritis (GCA) is the most common primary vasculitis and is associated with potential bilateral blindness. Neither clinical nor laboratory evidence is simple and unequivocal for this disease, which usually requires rapid and reliable diagnosis and therapy. The ophthalmologist should consider GCA with the following ocular symptoms: visual loss or visual field defects, transient visual disturbances (amaurosis fugax), diplopia, eye pain, or new onset head or jaw claudication. An immediate ophthalmological examination with slit lamp, ophthalmoscopy, and visual field, as well as color duplex ultrasound of the temporal artery should be performed...
April 9, 2024: Klinische Monatsblätter Für Augenheilkunde
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REVIEW
Szilvia Vajda, Bence Gunda, Krisztina Knézy, Péter Barsi, Csaba Varga, Pál Maurovich-Horvat, Dániel Bereczki, Zsolt Zoltán Nagy
BACKGROUND AND PURPOSE: <p>The management of central retinal artery occlusion (CRAO) has long been conservative therapy with limited efficacy carried out in ophthalmology departments together with etiolo­gi­cal investigations lacking a standardised protocol. However, CRAO is analogous to ischemic central nervous system stroke and is associated with increased stroke risk, thus, systemic thrombolysis treatment and multidisciplinary management can be beneficial. Since May 2022, at Semmelweis University CRAO patients diagnosed within 4...
March 30, 2024: Ideggyógyászati Szemle
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JOURNAL ARTICLE
Yoshiyuki Abe, Takao Fujii, Yoshia Miyawaki, Takahiko Sugihara, Haruhito A Uchida, Yasuhiro Maejima, Yoshiko Watanabe, Takuya Hashimoto, Takako Miyamae, Yoshikazu Nakaoka, Masayoshi Harigai, Naoto Tamura
OBJECTIVES: To access the real-world clinical management of physicians who treat Takayasu arteritis (TAK) and giant cell arteritis (GCA) after the publication of the Japanese Circulation Society (JCS) 2017 Guidelines for the Management of Vasculitis Syndrome. METHODS: This descriptive, cross-sectional study utilized self-administered electronic questionnaires, which were answered in February 2022 by physicians treating TAK or GCA and registered with Macromill Inc...
April 8, 2024: Modern Rheumatology
#30
JOURNAL ARTICLE
Lydia Zhong, Kaleigh F Roberts, Huiyi Chen, Gregory P Van Stavern, Leanne Stunkel
No abstract text is available yet for this article.
April 8, 2024: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
#31
REVIEW
Akerke Auanassova, Marlen Yessirkepov, Olena Zimba, Sakir Ahmed, Prakashini Mruthyunjaya
Systemic vasculitides are among the less common disorders encountered in routine rheumatology practice. The low incidence and heterogeneous presentation at onset can potentially lead to delayed diagnosis. Not recognizing these in the early phase may prove detrimental, as some vasculitis may progress to a catastrophic course with major morbidity or mortality. The causes of diagnostic delay may vary among different types of vasculitis and may also be disease-, patient-, or physician-related. Disease-related factors include the myriad presentations with diverse and non-specific symptoms, mimicking other conditions like infections...
April 8, 2024: Rheumatology International
#32
JOURNAL ARTICLE
Antonio Faraone, Alberto Fortini, Vanni Borgioli, Chiara Cappugi, Aldo Lo Forte, Valeria Maria Bottaro, Augusto Vaglio
BACKGROUND: eosinophilic granulomatosis with polyangiitis (EGPA) is a rare multisystem inflammatory disease characterized by asthma, eosinophilia and granulomatous or vasculitic involvement of various organs. While the eye is uncommonly affected in patients with EGPA, multiple ophthalmic manifestations have been reported, which can result in serious visual impairment without timely treatment. CASE REPORT: we report the case of a 79-year-old woman with a history of asthma and nasal polyps who presented with low-grade fever, mild alteration of mental status, and fatigue...
2024: European Journal of Case Reports in Internal Medicine
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JOURNAL ARTICLE
Sophie Gallou, Christian Agard, Anael Dumont, Samuel Deshayes, Jonathan Boutemy, Gwénola Maigné, Nicolas Martin Silva, Alexandre Nguyen, Rémi Philip, Olivier Espitia, Achille Aouba, Hubert de Boysson
OBJECTIVES: To identify factors associated with the progression of giant cell arteritis (GCA)-related or associated aortic dilations. METHODS: In this retrospective study, 47 GCA patients with aortic dilation were longitudinally analyzed. Each patient underwent ≥2 imaging scans of the aorta during the follow-up. Three progression statuses of aortic dilations were distinguished: fast-progressive (FP) defined by a progression of the aortic diameter ≥5 mm/year or ≥1 cm/2 years, slow progressive (SP) by a progression of the aortic diameter >1 mm during the follow-up, and not progressive (NP) when aortic diameter remained stable...
April 5, 2024: European Journal of Internal Medicine
#34
REVIEW
Philipp Bosch, Georgina Espigol-Frigolé, Maria C Cid, Susan P Mollan, Wolfgang A Schmidt
Since its first clinical description in 1890, extensive research has advanced our understanding of giant cell arteritis, leading to improvements in both diagnosis and management for affected patients. Imaging studies have shown that the disease frequently extends beyond the typical cranial arteries, also affecting large vessels such as the aorta and its proximal branches. Meanwhile, advances in comprehending the underlying pathophysiology of giant cell arteritis have given rise to numerous potential therapeutic agents, which aim to minimise the need for glucocorticoid treatment and prevent flares...
March 28, 2024: Lancet Rheumatology
#35
REVIEW
Kornelis S M van der Geest, Maria Sandovici, Thorsten A Bley, James R Stone, Riemer H J A Slart, Elisabeth Brouwer
Giant cell arteritis is the principal form of systemic vasculitis affecting people over 50. Large-vessel involvement, termed large vessel giant cell arteritis, mainly affects the aorta and its branches, often occurring alongside cranial giant cell arteritis, but large vessel giant cell arteritis without cranial giant cell arteritis can also occur. Patients mostly present with constitutional symptoms, with localising large vessel giant cell arteritis symptoms present in a minority of patients only. Large vessel giant cell arteritis is usually overlooked until clinicians seek to exclude it with imaging by ultrasonography, magnetic resonance angiography (MRA), computed tomography angiography (CTA), or [18 F]fluorodeoxyglucose-PET-CT...
March 28, 2024: Lancet Rheumatology
#36
REVIEW
Caezaan Keshvani, Noor Laylani, Pamela Davila-Siliezar, Jonathan Kopel, Andrew G Lee
INTRODUCTION: Vasculitides are a heterogeneous group of disorders producing inflammation of blood vessels (e.g. arteries or veins). All major vasculitides potentially have ophthalmological symptoms and signs including visual loss. Co-morbidity, multimorbidity, polypharmacy and geriatric syndromes all play important roles in patient outcomes for these rheumatic conditions in the elderly. This monograph reviews the NCBI PubMed database (Feb 2023) literature on the neuro-ophthalmic and geriatric considerations in vasculitis...
April 4, 2024: Expert Review of Clinical Immunology
#37
JOURNAL ARTICLE
Daniel Blockmans, Lien Moreel, Albrecht Betrains, Steven Vanderschueren, Walter Coudyzer, Lennert Boeckxstaens, Koen Van Laere
BACKGROUND: A positive PET scan at diagnosis was associated with a greater yearly increase in ascending and descending aortic diameter and thoracic aortic volume in patients with giant cell arteritis (GCA). Radiologic and histopathologic vascular abnormalities persist in a subset of treated patients despite clinical remission. The aim of this study was to evaluate the association between vascular FDG uptake during follow-up and the development of thoracic aortic aneurysms. METHODS: We recently performed a prospective cohort study of 106 GCA patients, who underwent FDG PET and CT imaging at diagnosis and CT imaging yearly for a maximum of 10 years...
2024: Frontiers in Medicine
#38
JOURNAL ARTICLE
Pierre-André Jarrot, Adrien Mirouse, Sébastien Ottaviani, Simon Cadiou, Jean-Hugues Salmon, Eric Liozon, Simon Parreau, Martin Michaud, Benjamin Terrier, Pierre-Edouard Gavand, Ludovic Trefond, Virginie Lavoiepierre, Jeremy Keraen, Daniel Rekassa, Bastien Bouldoires, Thierry Weitten, Damien Roche, Antoine Poulet, Caroline Charpin, Vincent Grobost, Marion Hermet, Magali Pallure, Chloe Wackenheim, Ludovic Karkowski, Pierre Grumet, Thomas Rogier, Nabil Belkefi, Vincent Pestre, Emilie Broquet, Amélie Leurs, Sophie Gautier, Valérie Gras, Pierre Gilet, Jan Holubar, Nadia Sivova, Nicolas Schleinitz, Jean-Marc Durand, Brice Castel, Alexandre Petrier, Robin Arcani, Baptiste Gramont, Philippe Guilpain, Hubert Lepidi, Pierre-Jean Weiller, Joelle Micallef, David Saadoun, Gilles Kaplanski
We conducted a national in-depth analysis including pharmacovigilance reports and clinical study to assess the reporting rate (RR) and to determine the clinical profile of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) in COVID-19-vaccinated individuals. First, based on the French pharmacovigilance database, we estimated the RR of PMR and GCA cases in individuals aged over 50 who developed their initial symptoms within one month of receiving the BNT162b2 mRNA, mRNA-1273, ChAdOx1 nCoV-19, and Ad26...
December 31, 2024: Human Vaccines & Immunotherapeutics
#39
JOURNAL ARTICLE
Mats Junek, Lillian Barra, Alexander Kopp, Tina Felfeli, Jodi Gatley, Jessica Widdifield
OBJECTIVE: To estimate the additional health care system costs associated with giant cell arteritis (GCA) in the year pre-diagnosis, post diagnosis, and over long-term follow up compared to individuals with similar demographics and comorbidities without GCA. METHODS: We performed a population-based study using health administrative data. Newly diagnosed cases of GCA (between 2002 and 2017 and ages 66 years and older) were identified using a validated algorithm and matched 1:6 to comparators using propensity scores...
April 1, 2024: Journal of Rheumatology
#40
JOURNAL ARTICLE
Alwin Sebastian, Kornelis S M van der Geest, Alessandro Tomelleri, Pierluigi Macchioni, Giulia Klinowski, Carlo Salvarani, Diana Prieto-Peña, Edoardo Conticini, Muhammad Khurshid, Lorenzo Dagna, Elisabeth Brouwer, Bhaskar Dasgupta
BACKGROUND: Giant cell arteritis is a critically ischaemic disease with protean manifestations that require urgent diagnosis and treatment. European Alliance of Associations for Rheumatology (EULAR) recommendations advocate ultrasonography as the first investigation for suspected giant cell arteritis. We developed a prediction tool that sequentially combines clinical assessment, as determined by the Southend Giant Cell Arteritis Probability Score (SGCAPS), with results of quantitative ultrasonography...
March 27, 2024: Lancet Rheumatology
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