Matteo Droghetti, Lorenzo Bianchi, Massimiliano Presutti, Luigia Vetrone, Andrea Farolfi, Riccardo Mei, Francesca Giunchi, Alessio Degiovanni, Angelo Mottaran, Pietro Piazza, Danilo Cangemi, Paolo Castellucci, Antonietta D'Errico, Riccardo Schiavina, Eugenio Brunocilla, Stefano Fanti
INTRODUCTION: Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed by normal prostatic tissue. Therefore, molecular imaging targeting PSMA (PSMA-PET) has gained particular interest and diffusion for PCa staging and restaging. Several factors may affect PSMA-PET results, and many tools have been proposed to improve patient selection. Furthermore, PSMA expression is not homogeneous among different tissues and within the prostate itself. The aims of this study were to evaluate immunohistochemistry (IHC) features of prostate biopsy samples and to assess their correlation with whole-mount specimens and PSMA-PET parameters...
2024: Frontiers in Oncology