Zhendong Du, Danni Tong, Xueqiu Chen, Fei Wu, Shengjun Jiang, Jingju Zhang, Yi Yang, Rui Wang, Sambuu Gantuya, Tserennyam Davaajargal, Sukhbaatar Lkhagvatseren, Zayat Batsukh, Aifang Du, Guangxu Ma
Nuclear hormone receptors (NHRs) are emerging target candidates against nematode infection and resistance. However, there is a lack of comprehensive information on NHR-coding genes in parasitic nematodes. In this study, we curated the nhr gene family for 60 major parasitic nematodes from humans and animals. Compared with the free-living model organism Caenorhabditis elegans, a remarkable contraction of the nhr family was revealed in parasitic species, with genetic diversification and conservation unveiled among nematode Clades I (10-13), III (16-42), IV (33-35) and V (25-64)...
May 26, 2024: Infection, Genetics and Evolution