Satoshi Yamada, Toshiya Itoh, Taro Ikegami, Atsushi Imai, Daiki Mochizuki, Hiroshi Nakanishi, Ryuji Ishikawa, Junya Kita, Yuki Nakamura, Yoshinori Takizawa, Jun Okamura, Yoshihiro Noda, Toshihide Iwashita, Takahiko Hariyama, Mikio Suzuki, Kiyoshi Misawa, Hideya Kawasaki
Recurrent respiratory papillomatosis (RRP) has a wide range of severity. We investigate the relationship between human papillomavirus (HPV) particle production and severity of RRP. From September 2005 to June 2021, 68 RRP samples (from 29 patients) were included. HPV type was determined. HPV viral load, physical status, and demographic and clinical characteristics were assessed. Immunohistochemistry (IHC) was performed for p16, Ki-67, L1, and E4. We used NanoSuit-CLEM (correlative light and electron microscopy) and transmission electron microscopy (TEM) to examine the samples...
April 6, 2023: Scientific Reports