Keywords Recurrent Respiratory Papillom...

Recurrent Respiratory Papillomatosis
Sanchita Kalita, Biswajit Gogoi, Gautam Khaund, Vivek Agarwal, Partha Pratim Borah, Anup Dutta, Daisy Gogoi
Otorhinolaryngologists, particularly dealing with airway cases, are subjected to highest risk of COVID 19 aerosolisation, self infection and transmission. Moreover, airway cases, which mostly present as emergency, cannot be deferred. Being a tertiary airway centre and having received a number of airway cases, most of them requiring prompt surgical intervention, our airway surgery and anaesthesiology team had to work in conjunction to adapt and readapt the practice over the past few months, striving to achieve effective airway surgery protocols, to minimize exposure and prevent transmission of COVID 19...
January 7, 2021: Indian Journal of Otolaryngology and Head and Neck Surgery
Mary C Bedard, Marion G Brusadelli, Adrean Carlile, Sonya Ruiz-Torres, Hannah Lodin, Denis Lee, Matthew Kofron, Paul F Lambert, Adam Lane, Najim Ameziane, El Mustapha Bahassi, Kathryn A Wikenheiser-Brokamp, Alessandro de Alarcon, David F Smith, Susanne I Wells
Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is driven by human papillomavirus (HPV) low-risk strains and is associated with significant morbidity. While previous studies of 2D cultures have shed light on disease pathogenesis and demonstrated the utility of personalized medicine approaches, monolayer cultures lack the 3D tissue architecture and physiology of stratified, sequentially differentiated mucosal epithelium important in RRP disease pathogenesis. Herein we describe the establishment of JoRRP-derived primary cell populations that retain HPV genomes and viral gene expression in culture...
January 6, 2021: Viruses
Qingwen Yang, Yanru Li, Lijing Ma, Yang Xiao, Huijun Wang, Yiming Ding, Rong Hu, Xiaoyi Wang, Lingzhen Meng, Jun Wang, Wen Xu
OBJECTIVE: To investigate the clinical characteristics and long-term outcomes of juvenile onset recurrent respiratory papillomatosis (JORRP) with or without pulmonary involvement. METHODS: A group of patients with JORRP who had clinical course over an extended period of time (at least 5 years) in the Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital were included in this retrospective study. Lung/bronchus involvement was revealed by lung imaging...
January 7, 2021: Laryngoscope
Douglas R Sidell, Karthik Balakrishnan, Simon R Best, Karen Zur, Julia Buckingham, Alessandro De Alarcon, Fuad M Baroody, Jonathan M Bock, Emily F Boss, Charles M Bower, Paolo Campisi, Sharon F Chen, Jeffrey M Clarke, Kevin D Clarke, Alejandro Cocciaglia, Robin T Cotton, Giselle Cuestas, Kara L Davis, Victor H DeFago, Frederik G Dikkers, Ines Dossans, Walter Florez, Elizabeth Fox, Aaron D Friedman, Nazaneen Grant, Osama Hamdi, Norman D Hogikyan, Kaalan Johnson, Liane B Johnson, Romaine F Johnson, Peggy Kelly, Adam M Klein, Claire M Lawlor, Nicolas Leboulanger, Alejandro G Levy, Derek Lam, Greg R Licameli, Steve Long, David G Lott, Dayse Manrique, James Scott McMurray, Kara D Meister, Anna H Messner, Michael Mohr, Pamela Mudd, Anthony J Mortelliti, Daniel Novakovic, Julian Ongkasuwan, Shazia Peer, Krysztof Piersiala, Jeremy D Prager, Seth M Pransky, Diego Preciado, Tiffany Raynor, Rico N P M Rinkel, Hugo Rodriguez, Verónica P Rodríguez, John Russell, María Laura Scatolini, Patrick Scheffler, David F Smith, Lee P Smith, Marshall E Smith, Richard J H Smith, Abraham Sorom, Amalia Steinberg, John A Stith, Dana Thompson, Jerome W Thompson, Patricio Varela, David R White, Andre M Wineland, Christina J Yang, Carlton J Zdanski, Craig S Derkay
OBJECTIVES/HYPOTHESIS: The purpose of this study is to develop consensus on key points that would support the use of systemic bevacizumab for the treatment of recurrent respiratory papillomatosis (RRP), and to provide preliminary guidance surrounding the use of this treatment modality. STUDY DESIGN: Delphi method-based survey series. METHODS: A multidisciplinary, multi-institutional panel of physicians with experience using systemic bevacizumab for the treatment of RRP was established...
January 6, 2021: Laryngoscope
Georg Evers, Christoph Schliemann, Achim Beule, Lars-Henning Schmidt, Arik B Schulze, Christina Kessler, Thomas K Hoffmann, Rainer Wiewrodt, Andreas H Groll, Annalen Bleckmann, Claudia Rudack, Wolfgang E Berdel, Michael Mohr
OBJECTIVES/HYPOTHESIS: Recurrent respiratory papillomatosis (RRP) is a primarily benign disease affecting the entire respiratory tract. Treatment is challenging and usually involves surgical interventions and adjuvant medications. Previously, promising results on systemic administration of bevacizumab have been reported. However, experience on long-term systemic use in patients with RRP is not yet available. Here, we present our long-term follow-up on RRP patients undergoing systemic bevacizumab treatment...
December 31, 2020: Laryngoscope
Marta Filauro, Alberto Vallin, Marco Fragale, Claudio Sampieri, Luca Guastini, Francesco Mora, Giorgio Peretti
Objective: Development of transnasal fiberoptic laryngoscopy, integration of an operative channel (OC), the advent of high-definition television imaging, with improvements in laser technology, cleared the way for office-based laryngology. Three treatment categories can be identified: bioendoscopy-guided biopsy; laryngeal injection; laser-assisted surgery. Methods: 26 patients underwent OBPs at the Otolaryngology Clinic of IRCCS Policlinico San Martino, Genoa, Italy...
December 29, 2020: Acta Otorhinolaryngologica Italica
Shivagamasundari Murali, Prasanna Kumar Saravanam, Nethra Dinakaran
Juvenile respiratory laryngeal papillomatosis is a subset of a larger clinical entity of recurrent respiratory papillomatosis. It is characterised by the development of recurrent papillomata in the vocal folds. Human papillomavirus types 6 and 11 has been implicated to be the most common strain of virus associated with the formation of laryngeal papilloma. Clinical diagnosis is based on typical appearance of warty lesion on endoscopy. Surgery is the primary line of management along with adjuvant therapy like antiviral drugs and immunomodulators...
December 22, 2020: BMJ Case Reports
Pamela Mudd, Emily Wikner, Md Sohel Rana, George Zalzal
OBJECTIVE/HYPOTHESIS: Determine if the presentation of voice versus airway symptoms at the time of diagnosis of juvenile recurrent respiratory papillomatosis (JORRP) correlates with treatment and outcomes. STUDY DESIGN: Original report, Retrospective review. METHODS: Twenty year retrospective review of all patients with JORRP presenting at any time in treatment to a single tertiary children's hospital between 1997 and 2017. RESULTS: Fifty-four patients presented with a diagnosis of JORRP during the 20 year study period...
December 17, 2020: Laryngoscope
Geraldine Labedz, María Laura Scatolini, Silvina Ruvinsky, Hugo Anibal Rodriguez
OBJECTIVES/HYPOTHESIS: To identify factors associated to increased risk of extra-laryngeal spread in pediatric patients with recurrent respiratory papillomatosis (RRP). STUDY DESIGN: Retrospective chart review. METHODS: A retrospective study was conducted evaluating the clinical charts of patients younger than 16 years with histopathologically confirmed RRP treated between January 2014 and December 2018. Characteristics of patients with and without extra-laryngeal disease dissemination were compared...
December 4, 2020: Laryngoscope
Martin Formánek, Debora Formánková, Pavel Hurník, Adéla Vrtková, Pavel Komínek
OBJECTIVE: Human papillomavirus (HPV) causes adult onset recurrent respiratory papillomatosis (AORRP), but AORPP prevalence is much lower than HPV prevalence. Thus, HPV infection is necessary, but not sufficient, to cause AORRP and other factors likely contribute to its pathogenesis. The present study aimed to investigate whether co-infection with herpetic viruses may contribute to the pathogenesis of AORRP. DESIGN: Prospective case-control study conducted from January 2018 to November 2019...
December 2, 2020: Clinical Otolaryngology
Mengya Shen, Yang Xiao, Lijing Ma, Jun Wang
<b/> Recurrent respiratory papillomatosis (RRP) is a benign tumor of the respiratory tract caused by human papillomavirus (HPV) infection. At present, there is no cure for this disease, and mainly depends on surgical resection to relieve symptoms but cannot prevent recurrence. Multiple surgeries will bring heavy mental and economic burdens to patients and their families. Therefore, researchers are constantly seeking new treatments to reduce the number of operations and prevent recurrence. Hence, research on adjuvant therapy drugs has also been widely carried out, including bevacizumab, cidofovir, HPV vaccine, and Chinese medicine as an adjuvant drug according some reports...
December 2020: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Andrew Tkaczuk, Sumita Trivedi, Mayur D Mody, Conor E Steuer, Dong M Shin, Adam M Klein, Nabil F Saba
OBJECTIVES/HYPOTHESIS: Recurrent respiratory papillomatosis (RRP) is a rare, potentially life-threatening, disease that impacts the voice, breathing, and quality of life of patients. Frequent surgical interventions may be needed to control symptoms. We examined the safety and efficacy of utilizing parenteral bevacizumab in the management of severe RRP in adults. STUDY DESIGN: This is a retrospective review of clinical management approaches in a group of patients with severe RRP defined as having a high disease burden, frequent need for debridement, and/or tracheobronchial disease...
October 27, 2020: Laryngoscope
Luisa Dassi, Clorinda Annunziata, Chiara Botti, Alberto Micillo, Andrea Cerasuolo, Noemy Starita, Franco M Buonaguro, Maria Lina Tornesello
Vertical transmission of human papillomaviruses (HPVs) from mother to infant is known to occur during labor, delivery or breastfeeding. Infection with mucosal HPV 6 and 11 may cause recurrent respiratory papillomatosis in children, which is a rare and severe respiratory disease. The cutaneous HPV genotypes have also been described to be transmitted from mother to newborn through skin-to-skin contacts and during breastfeeding. To investigate the perinatal transmission of alpha and beta HPVs we collected nasopharyngeal specimens from 0-12-months-old infants born by vaginal delivery and breastfed at the time of sample collection...
October 1, 2020: Viruses
Charles Lépine, Thibault Voron, Dominique Berrebi, Marion Mandavit, Marine Nervo, Sophie Outh-Gauer, Hélène Péré, Louis Tournier, Natacha Teissier, Eric Tartour, Nicolas Leboulanger, Louise Galmiche, Cécile Badoual
Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is a condition related to HPV 6 and 11 infection which is characterized by the repeated growth of benign exophytic papilloma in the respiratory tract. Disease progression is unpredictable: some children experience minor symptoms, while others require multiple interventions due to florid growth. The aim of this study was to explore the biomarkers of JoRRP severity on a bicentric cohort of forty-eight children. We performed a CISH on the most recent sample of papilloma with a probe targeting the mRNA of the E6 and E7 genes of HPV 6 and 11 and an immunostaining with p16INK4a antibody...
October 1, 2020: Cancers
Benjamin John Miller, Amr Abdelhamid, Yakubu Karagama
BACKGROUND: The recent introduction of 445 nm blue laser to office-based laryngology presents potential advantages. These include a desirable combination of cutting and photoangiolytic qualities and a lightweight, shock-resistant design. Despite its increasing use, current evidence is limited to experimental data and case reports. OBJECTIVES: The authors present a case series and overview of office blue laser transnasal flexible laser surgery (TNFLS), considering indications, patient selection, safety, technique, and surgical outcomes...
September 24, 2020: Ear, Nose, & Throat Journal
Marisa A Ryan, Grace R Leu, Patrick A Upchurch, David E Tunkel, Jonathan M Walsh, Emily F Boss
OBJECTIVES: Juvenile onset recurrent respiratory papillomatosis (JORRP) can cause severe or disseminated disease. Surgical treatment may be inadequate. Systemic bevacizumab has shown initial success for severe JORRP. The objective of this systematic review was to assess usage, effectiveness, and safety of this treatment. METHODS: We searched PubMed, Embase, and Web of Science for studies of humans with JORRP treated with systemic bevacizumab. Two researchers independently reviewed the studies to determine inclusion and aggregate data on patient characteristics, dosing protocols, treatment response, adverse events, and level of evidence...
September 22, 2020: Laryngoscope
Laura Sichero, Silvaneide Ferreira, Rossana Verónica Mendoza López, Barbara Pereira Mello, Victor Costa, Vivian Narana Ribeiro El-Achkar, Román Carlos, Alfredo Ribeiro-Silva, Shirley Pignatari, Estela Kaminagakura, Luisa Lina Villa
Human papillomavirus (HPV) types 6 and 11 are the etiological agents of recurrent respiratory papillomatosis (RRP). We examined the prevalence and distribution of HPVs 6 and 11 genetic variants in juvenile onset (JORRP) and adult onset (AORRP) laryngeal papillomas. Cases of JORRP and AORRP were collected retrospectively. HPV detection and genotyping were accessed by PCR-sequencing in 67 RRP samples. Overall, the most prevalent HPV-6 variants were from B1 (55.8%) and B3 (27.9%) sublineages, whereas among HPV-11 positive samples A2 (62...
September 10, 2020: Journal of Medical Virology
Yiressy Izaguirre Baday, Julina Ongkasuwan, Rajkumar Venkatramani
Recurrent respiratory papillomatosis (RRP) is a benign tumor of the respiratory tract associated with human papillomavirus 6 and 11. Patients undergo multiple surgical debridements for management of growing papilloma. Adjuvant treatment options for RRP in children are often ineffective and do not decrease the need for repeated surgical debridement. We report on three patients with severe disease refractory to surgery who were treated with 10 mg/kg systemic bevacizumab every 4 weeks. All patients had improvement in voice and reduced need for surgical debridement...
September 2, 2020: International Journal of Pediatric Otorhinolaryngology
Habie Thomas Samuel, Lalee Varghese, Regi Kurien, Meera Thomas
Inverted papillomas are rare tumors in the pediatric population and have not been reported in children less than two years. These tumors may produce respiratory distress in patients, particularly if they ectopically occur in the airway. Human papilloma virus is one of the known etiologies for many head and neck neoplasms including inverted papillomas and squamous papillomas. We report a child who was surgically treated at fifteen months of age for inverted papilloma of the pharynx who subsequently developed squamous papilloma of the larynx which persisted as a recurrent respiratory papillomatosis...
August 29, 2020: International Journal of Pediatric Otorhinolaryngology
Virgilijus Uloza, Alina Kuzminienė, Jolita Palubinskienė, Ingrida Balnytė, Ingrida Ulozienė, Angelija Valančiūtė
OBJECTIVES/HYPOTHESIS: To investigate the growth pattern of recurrent respiratory papilloma (RRP) implants on chicken embryo chorioallantoic membranes (CAMs) and to evaluate possible associations between the clinical course of the disease and the behavior of experimentally implanted RRP tumors. STUDY DESIGN: Experimental study. METHODS: Fresh 172 RRP tissue samples from 12 patients were implanted onto chick embryo CAMs. Morphological and morphometric analysis of the experimental CAM and chorionic epithelium was performed...
September 7, 2020: Laryngoscope
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