Xin Hu, Keyu Pan, Min Zhao, Jiali Lv, Jing Wang, Xiaofeng Zhang, Yuxi Liu, Yulu Song, Aaron T Gudmundson, Richard A E Edden, Fuxin Ren, Tao Zhang, Fei Gao
During aging, the brain is subject to greater oxidative stress (OS), which is thought to play a critical role in cognitive impairment. Glutathione (GSH), as a major antioxidant in the brain, can be used to combat OS. However, how brain GSH levels vary with age and their associations with cognitive function is unclear. In this study, we combined point-resolved spectroscopy and edited spectroscopy sequences to investigate extended and closed forms GSH levels in the anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and occipital cortex (OC) of 276 healthy participants (extended form, 166 females, age range 20-70 years) and 15 healthy participants (closed form, 7 females, age range 26-56 years), and examined their relationships with age and cognitive function...
May 1, 2024: NeuroImage