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JOURNAL ARTICLE
Noam E Kopmar, Kim Quach, Ted A Gooley, Christen H Martino, Sindhu Cherian, Mary-Elizabeth M Percival, Anna B Halpern, Cristina M Ghiuzeli, Vivian G Oehler, Janis L Abkowitz, Roland B Walter, Ryan D Cassaday
IMPORTANCE: Options for adults with relapsed or refractory B-cell acute lymphoblastic leukemia or lymphoma (B-ALL) are limited, and new approaches are needed. Inotuzumab ozogamicin (InO) has been combined with low-intensity chemotherapy, with modest improvements over historical controls, and dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-EPOCH) treatment is safe and active for newly diagnosed ALL. OBJECTIVE: To assess the safety and clinical activity of DA-EPOCH and InO in adults with relapsed or refractory B-ALL...
May 9, 2024: JAMA Oncology
#2
JOURNAL ARTICLE
Christian Récher
No abstract text is available yet for this article.
May 9, 2024: Blood
#3
REVIEW
Subrat Kumar Acharya
Acute liver failure (ALF) is an infrequent, but serious complication subsequent to severe acute liver injury (sALI) due to various hepatotoxic agents such as hepatotropic virus(es) and drugs such as anti-tubercular medications, paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics and anti-cancer and anti-epileptic therapy and due to metabolic and autoimmune disease flares. ALF after sALI presents with encephalopathy associated with prolonged international normalized ratio (INR). Mortality in ALF is high and ranges between 50% and 80%...
May 9, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#4
JOURNAL ARTICLE
Walter Schmitt, Christian Diedrich, Taye H Hamza, Michaela Meyer, Thomas Eissing, Stefanie Breitenstein, Joseph W Rossano, Steven E Lipshultz
Plasma N-terminal prohormone B-type natriuretic peptide (NT-proBNP) concentration is a heart failure (HF) biomarker in adults and children. Its prognostic value for HF-related events has been established only in adults. Therefore, we aimed to test the hypothesis that plasma NT-proBNP concentrations predicted the risk of heart transplantation or death in children with HF. We studied the medical records of 109 children with HF enrolled in the IBM Watson Explorys database and from 150 children enrolled in the Pediatric Cardiomyopathy Registry (PCMR)...
May 9, 2024: Pediatric Cardiology
#5
JOURNAL ARTICLE
Christie Rampersad, Chris Wiebe, Robert Balshaw, Jared Bullard, Ian W Gibson, Aaron Trachtenberg, James Shaw, Armelle Perez Cortes Villalobos, Martin Karpinski, Aviva Goldberg, Patricia Birk, Maury Pinsk, David N Rush, Peter W Nickerson, Julie Ho
BACKGROUND: Immunosuppression reduction for BK polyoma virus (BKV) must be balanced against risk of adverse alloimmune outcomes. We sought to characterize risk of alloimmune events after BKV within context of HLA-DR/DQ molecular mismatch (mMM) risk score. METHODS: This single-center study evaluated 460 kidney transplant patients on tacrolimus-mycophenolate-prednisone from 2010-2021. BKV status was classified at 6-months post-transplant as "BKV" or "no BKV" in landmark analysis...
May 2024: Clinical Transplantation
#6
REVIEW
J Zhou, C Liu, P Amornphimoltham, S C Cheong, J S Gutkind, Q Chen, Z Wang
The prognosis and survival rate of head and neck squamous cell carcinoma (HNSCC) have remained unchanged for years, and the pathogenesis of HNSCC is still not fully understood, necessitating further research. An ideal animal model that accurately replicates the complex microenvironment of HNSCC is urgently needed. Among all the animal models for preclinical cancer research, tumor-bearing mouse models are the best known and widely used due to their high similarity to humans. Currently, mouse models for HNSCC can be broadly categorized into chemical-induced models, genetically engineered mouse models (GEMMs), and transplanted mouse models, each with its distinct advantages and limitations...
May 9, 2024: Journal of Dental Research
#7
JOURNAL ARTICLE
Michael McCabe, Ashwani Sharma, Randeep Kashyap, Karen Pineda-Solis, Amit Nair, Jean Joseph, Guan Wu
Introduction: Urologic complications are thought to be the most common surgical complication of renal transplantation. Ureteral pathology, including stenosis, urine leak, and vesicoureteral reflux, predominates. Although endourologic and interventional radiological management may be utilized, failure rates remain relatively high and surgical reconstruction remains the definitive management. Robotic ureteral reconstruction has been demonstrated to provide patient benefit in nontransplant populations, but the literature on transplant reconstruction is very limited...
May 9, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
#8
JOURNAL ARTICLE
Jun Wang, Dong Mao, BeiChen Dai, YongJun Rui
Background: Injury of peripheral nerve capable of regeneration with much poorer prognosis affects people's life quality. The recovery of nerve function after transplantation for peripheral nerve injury remain a worldwide problem. Silicon-induced biofilms as vascularized biological conduits can promote nerve regeneration by encapsulating autologous or allogeneic nerve graft. Objective: We proposed to explore the effect of silicon-induced biofilms on nerves regeneration and whether the VEGF/VEGFR2/ERK pathway was involved in the present study...
May 9, 2024: Neurological Research
#9
REVIEW
Georgios Kourounis, Samuel J Tingle, Thomas J Hoather, Emily R Thompson, Alistair Rogers, Tobias Page, Aliu Sanni, David A Rix, Naeem A Soomro, Colin Wilson
BACKGROUND: Waiting lists for kidney transplantation continue to grow. Live kidney donation significantly reduces waiting times and improves long-term outcomes for recipients. Major disincentives to potential kidney donors are the pain and morbidity associated with surgery. This is an update of a review published in 2011. OBJECTIVES: To assess the benefits and harms of open donor nephrectomy (ODN), laparoscopic donor nephrectomy (LDN), hand-assisted LDN (HALDN) and robotic donor nephrectomy (RDN) as appropriate surgical techniques for live kidney donors...
May 9, 2024: Cochrane Database of Systematic Reviews
#10
JOURNAL ARTICLE
Michael Prodanuk, Kathryn Timberlake, Alicia Koo, Yogi Chopra, Donna A Wall, Michelle Science
Levofloxacin prophylaxis during periods of neutropenia in pediatric hematopoietic stem cell transplant (HSCT) may reduce the number of febrile episodes and use of empiric intravenous antibiotics (EIA); however, the literature is conflicting. This retrospective review compared EIA use before and after implementation of levofloxacin prophylaxis at a children's hospital. Levofloxacin prophylaxis was associated with reduced use of certain EIA; however, did not reduce the number of positive blood cultures or clinical deteriorations...
May 9, 2024: Pediatric Blood & Cancer
#11
JOURNAL ARTICLE
Cricket Gullickson, Leslie Kersun, Anne Reilly, Alix Seif, Leena Chehab
The addition of rituximab to standard regimens for primary mediastinal large B-cell lymphoma (PMBCL) has significantly improved overall survival. However, the optimal management of isolated central nervous system (CNS) relapse and role of CNS prophylaxis remains undefined. We present cases of two adolescents with PMBCL who developed isolated CNS relapses. While isolated CNS relapse may be managed with high-dose chemotherapy and autologous stem cell transplant with or without CNS radiotherapy, review of these cases and the literature highlight the need for further work to define risk factors for CNS relapse, and identify patients who may benefit from CNS prophylaxis...
May 9, 2024: Pediatric Blood & Cancer
#12
Jason J Han
As a second porcine kidney xenotransplant case in a human recipient to date, this breakthrough technology offers an option even to patients with complex multiorgan failures, who may not be candidates for a conventional organ transplant.
May 9, 2024: Artificial Organs
#13
JOURNAL ARTICLE
Yoshiko Atsuta, Helen Baldomero, Daniel Neumann, Anna Sureda, Jakob D DeVos, Minako Iida, Amado Karduss, Duncan Purtill, Alaa M Elhaddad, Nosa G Bazuaye, Carmem Bonfim, Rafael De la Camara, Naeem A Chaudhri, Fabio Ciceri, Cinthya Correa, Cristobal Frutos, Sebastian Galeano, Laurent Garderet, Oscar Gonzalez-Ramella, Raffaella Greco, Nada Hamad, Mette D Hazenberg, Mary M Horowitz, Krzysztof Kalwak, Bor-Sheng Ko, Yoshihisa Kodera, Mickey Bc Koh, Kaiyan Liu, Donal P McLornan, Joon Ho Moon, Benedicte Neven, Shinichiro Okamoto, Marcelo C Pasquini, Jakob R Passweg, Kristjan Paulson, Damiano Rondelli, Annalisa Ruggeri, Adriana Seber, John A Snowden, Alok Srivastava, Jeff Szer, Daniel Weisdorf, Nina Worel, Hildegard Greinix, Wael Saber, Mahmoud Aljurf, Dietger Niederwieser
Promoting access to and excellence in hematopoietic cell transplantation (HCT) by collecting and disseminating data on global HCT activities is one of the principal activities of the Worldwide Network for Blood and Marrow Transplantation, a non-Governmental organization in working relations with the World Health Organization. HCT activities are recorded annually by member societies, national registries and individual centers including indication, donor type (allogeneic/autologous), donor match and stem cell source (bone marrow/peripheral blood stem cells/cord blood)...
May 9, 2024: Haematologica
#14
JOURNAL ARTICLE
Lisa V E Oostenbrink, Erik G J Von Asmuth, Cornelia M Jol-van der Zijde, Anja M Jansen-Hoogendijk, Carly Vervat, Robbert G M Bredius, Maarten J D Van Tol, Marco W Schilham, Petr Sedlacek, Marianne Ifversen, Adriana Balduzzi, Peter Bader, Christina Peters, Dirk Jan A R Moes, Arjan C Lankester
Anti T-lymphocyte globulin (ATLG) is used in hematopoietic stem cell transplantation (HSCT) to prevent graft-versus-host disease (GvHD) and graft failure. To date, insight in ATLG pharmacokinetics and -dynamics (PK/PD) is limited, and population PK (POPPK) models are lacking. In this prospective study, we describe ATLG POPPK using NONMEM® and the impact of ATLG exposure on clinical outcome and immune reconstitution in a homogeneous cohort of pediatric acute lymphoblastic leukemia (ALL) patients transplanted with a matched unrelated donor and receiving uniform ATLG dosing...
May 9, 2024: Haematologica
#15
JOURNAL ARTICLE
Zixian Liu, Jinhong Wang, Yao Ma, Miner Xie, Peng Wu, Sen Zhang, Xiaofang Wang, Fang Dong, Hui Cheng, Ping Zhu, Mingzhe Han, Hideo Ema
Hematopoietic stem cells (HSCs) have been considered to progressively lose their self-renewal and differentiation potentials prior to the commitment to each blood lineage. However, recent studies have suggested that megakaryocyte progenitors (MkPs) are generated at the level of HSCs. In this study, we newly identified early megakaryocyte lineage-committed progenitors (MgPs) mainly in CD201- CD48- cells and CD48+ cells separated from the CD150+ CD34- Kit+ Sca-1+ Lin- HSC population of the bone marrow in adult mice...
April 2024: Blood Sci
#16
Navaneethan Subramanian, Abhishek Yadav, Jithin S Kumar, George P Abraham
BACKGROUND: Primary type 2 hyperoxaluria is a very rare genetic disorder,1,2 where in the progression to renal failure was assumed to be insidious and not very common.3 PH2 is due to deficient glyoxylate reductase/hydroxypyruvate reductase (GRHPR),1,2 which was thought to have extra-hepatic production also.4 The progression to renal failure in these patient subgroups is well documented in the Literature and the role of SLK (simultaneous liver and kidney transplantation) has not been clearly established...
2024: Journal of Clinical and Experimental Hepatology
#17
EDITORIAL
Montserrat Fernandez Guarino, Stefano Bacci
No abstract text is available yet for this article.
2024: Frontiers in Medicine
#18
Sean M Muir, Alyssa McMandon, Siena C Lombardozzi, James D McDermott
The meniscus of the knee serves as a crucial load-bearing structure, and its damage can significantly impact weight distribution. In addressing focal meniscal defects, segmental meniscal allograft transplantation (SMALT) emerges as an innovative solution. Here, we detail a case involving a young, active female who underwent SMALT augmented with osteochondral allograft transplantation (OCA) and bone marrow aspirate concentration (BMAC). The patient, a 40-year-old former Division I volleyball player, previously underwent arthroscopic procedures and presented with knee pain alongside complex lateral meniscus tear evident in magnetic resonance imaging (MRI) findings...
April 2024: Curēus
#19
Olivia Ziegler, Neekita R Jikaria, Joseph Cioccio, Jeffery S Scow
Graft-versus-host disease (GvHD) is a common complication following hematopoietic stem cell transplant (HSCT) and has protean manifestations. It results from the activation of transplanted T lymphocytes against the HLA antigens of recipient cells, resulting in tissue destruction. The most commonly involved sites of acute GvHD are the skin and gut, with high mortality reported in the latter. Historically, surgery for gut GvHD has been reserved for those with frank perforations or uncontrolled hemorrhage. Here, we present a case of steroid and ruxolitinib refractory colonic GvHD in a 41-year-old female, which was ultimately managed with robotic-assisted total abdominal colectomy with resolution of enteric symptoms...
April 2024: Curēus
#20
REVIEW
Hiroshi Date
Due to the difficulty of finding brain-dead donors, in October 1998, I performed the first living-donor lobar lung transplantation (LDLLT) for a ventilator-dependent 24-year-old female patient with bronchiectasis using lobes from her parents. The patient is still alive and in good health 25 years after the transplantation. Over time, the indications for LDLLT have expanded to include pulmonary hypertension, pulmonary fibrosis, congenital genetic diseases, pulmonary complications after stem cell transplantation, and, more recently, severe lung injury due to COVID-19 infection...
April 15, 2024: JMA journal
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