Emanuele Lagazzi, Helen S Wei, Vahe S Panossian, Jessica B Pallotta, Anet Calisir, Wardah Rafaqat, May Abiad, Ikemsinachi C Nzenwa, David R King, Celestine Hong, Paula Hammond, Bradley Olsen, Michael J Duggan, George C Velmahos
PURPOSE: Noncompressible truncal hemorrhage remains a leading cause of preventable death in the prehospital setting. Standardized and reproducible large animal models are essential to test new therapeutic strategies. However, existing injury models vary significantly in consistency and clinical accuracy. This study aims to develop a lethal porcine model to test hemostatic agents targeting noncompressible abdominal hemorrhages. METHODS: We developed a two-hit injury model in Yorkshire swine, consisting of a grade IV liver injury combined with hemodilution...
May 23, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society