Hira Mohyuddin, Blanca Laffon, João P Teixeira, Solange Costa, Armanda Teixeira-Gomes, Eduardo Pásaro, Niel Constantine, Aline Dagdag, Heidi K Ortmeyer, Boris Tizenberg, Liubov Afram, Poyu Yen, Christopher Marano, Christopher A Lowry, Andrew J Hoisington, Jill A RachBeisel, Vanessa Valdiglesias, Carlota Lema-Arranz, Natalia Fernández-Bertólez, Ana Maseda, José C Millán-Calenti, Elizabeth J Kovacs, Johanna M Gostner, Dietmar Fuchs, Lisa A Brenner, Laura Lorenzo-López, Teodor T Postolache
BACKGROUND: Persistent inflammation related to aging ("inflammaging") is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty. METHODS: We analyzed available demographic, social, and clinical data in Spanish and Portuguese older adults [N = 601; age: mean (SD) 77...
November 6, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences