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JOURNAL ARTICLE
Massimo Mapelli, Irene Mattavelli, Elisabetta Salvioni, Nicolò Capra, Alice Bonomi, Gaia Cattadori, Beatrice Pezzuto, Jeness Campodonico, Arianna Piotti, Alessandro Nava, Massimo Piepoli, Damiano Magrì, Stefania Paolillo, Ugo Corrà, Rosa Raimondo, Rocco Lagioia, Carlo Vignati, Roberto Badagliacca, Pasquale Perrone Filardi, Michele Senni, Michele Correale, Mariantonietta Cicoira, Marco Metra, Marco Guazzi, Giuseppe Limongelli, Gianfranco Parati, Fabiana De Martino, Francesco Bandera, Maurizio Bussotti, Federica Re, Carlo M Lombardi, Angela B Scardovi, Susanna Sciomer, Andrea Passantino, Michele Emdin, Caterina Santolamazza, Enrico Perna, Claudio Passino, Gianfranco Sinagra, Piergiuseppe Agostoni
INTRODUCTION: Risk stratification in heart failure (HF) is essential for clinical and therapeutic management. The Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score is a validated prognostic model for assessing cardiovascular risk in HF patients with reduced ejection fraction (HFrEF). From the validation of the score, the prevalence of HF patients treated with direct oral anticoagulants (DOACs), such as edoxaban, for non-valvular atrial fibrillation (NVAF) has been increasing in recent years...
December 23, 2023: Journal of Clinical Medicine
#2
REVIEW
Yue-Yue Niu, Aikeremu Aierken, Ling Feng
BACKGROUND: When specific nutrients are inadequate, vulnerability to cardiovascular and metabolic illnesses increases. The data linking dietary nutrition with these illnesses, however, has been sparse in the past observational research and randomized controlled trials. OBJECTIVES: A Mendelian randomization (MR) analysis was performed to assess the influence of macronutrients (fat, protein, sugar, and carbohydrates) and micronutrients (β-carotene, folate, calcium, iron, copper, magnesium, phosphorus, selenium, zinc, vitamin C, vitamin D, vitamin B, and vitamin B12) on the susceptibility to cardiovascular metabolic disorders, including coronary artery disease, heart failure, ischemic stroke, and type 2 diabetes...
October 10, 2023: Heart & Lung: the Journal of Critical Care
#3
JOURNAL ARTICLE
Renate B Schnabel, Pietro Ameri, Jolanta M Siller-Matula, Igor Diemberger, Marianne Gwechenberger, Ladislav Pecen, Marius Constantin Manu, José Souza, Raffaele De Caterina, Paulus Kirchhof
AIMS: Heart failure (HF) is a risk factor for major adverse events in atrial fibrillation (AF). Whether this risk persists on non-vitamin K antagonist oral anticoagulants (NOACs) and varies according to left ventricular ejection fraction (LVEF) is debated. METHODS AND RESULTS: We investigated the relation of HF in the ETNA-AF-Europe registry, a prospective, multicentre, observational study with an overall 4-year follow-up of edoxaban-treated AF patients. We report 2-year follow-up for ischaemic stroke/transient ischaemic attack (TIA)/systemic embolic events (SEE), major bleeding, and mortality...
August 2, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#4
JOURNAL ARTICLE
Antonis A Manolis, Theodora A Manolis, Helen Melita, Antonis S Manolis
Cardiovascular (CV) disease (CVD) is a major cause of morbidity and mortality world-wide, thus it is important to adopt preventive interventions. Observational data demonstrating CV benefits of vitamin supplements, advanced by self-proclaimed experts have resulted in ~50% of Americans reporting the use of multivitamins for health promotion; this practice has led to a multi-billion-dollar business of the multivitamin-industry. However, the data on the extensive use of multivitamins show no consistent benefit for CVD prevention or all-cause mortality, while the use of certain vitamins might prove harmful...
September 12, 2023: Current Vascular Pharmacology
#5
JOURNAL ARTICLE
Rui-Li Sun, Huan-Huan Wang, Zi-Chen Gui, Shuang-Guo, Lai-Biao Lin, Jia-Xin Fan, Xue-Zhang, Bin-Yan Mao, Geng Liu, Wei-Zhen Liu, Rui-Zhu Yue, Ya-Ling Yin, Qian-Qian Wang, Peng Li
Doxorubicin (DOX) has been used to treat various types of cancer, but its application is limited due to its heart toxicity as well as other drawbacks. Chronic inhibition of Na+ /H+ exchanger (NHE1) reduces heart failure and reduces the production of reactive oxygen species (ROS); vitamin B6 (VitB6 ) has been demonstrated to have a crucial role in antioxidant mechanism. So, this study was designed to explore the effect of VitB6 supplement on the DOX-induced cardiotoxicity and to imply whether NHE1 is involved...
September 13, 2023: Journal of Biochemical and Molecular Toxicology
#6
JOURNAL ARTICLE
Antonis A Manolis, Theodora A Manolis, Helen Melita, Antonis S Manolis
Cardiovascular disease (CVD) is a major cause of morbidity/mortality world-wide, hence preventive interventions are crucial. Observational data showing beneficial CV-effects of vitamin supplements, promoted by self-proclaimed experts, have led to ~50% of Americans using multivitamins; this practice has culminated into a multi-billion-dollar business. However, robust evidence is lacking, and certain vitamins might incur harm. This two-part review focuses on the attributes or concerns about specific vitamin consumption on CVD...
September 11, 2023: Current Vascular Pharmacology
#7
Alpha Oumar Diallo, Amelie Marcou, Jérémie Lespinasse, Zaida Cordoba-Sosa, Emmanuel Andrès, Léa Docquier, Noel Lorenzo-Villalba
A 76-year-old patient previously admitted to the cardiology department for replacement of a right ventricular lead on a double-chamber pacemaker was admitted to the internal medicine department 15 days after for bronchopneumopathy. His past medical history was relevant for Type 2 diabetes mellitus, heart failure due to dilated hypokinetic heart disease, transcatheter aortic valve implantation (TAVI), and chronic myelomonocytic leukemia (CMML-0) diagnosed in 2021. Twenty-four hours after admission, the patient's general condition deteriorated abruptly, with the onset of drowsiness and psychomotor retardation...
September 2023: Clinical Case Reports
#8
JOURNAL ARTICLE
Nandi Bao, Xiaoli Liu, Xiaoling Zhong, Shuangshuang Jia, Ning Hua, Li Zhang, Guoxin Mo
AIM: To investigate the potential microbiome profile of a mouse model with heart failure (HF) during dapagliflozin treatment. METHOD: An HF model was constructed in 8-week-old male mice, and cardiac tissues were analyzed using histological staining. Hemodynamic indexes were measured, and fecal samples were collected for 16S rDNA sequencing. Chao1, Shannon, and Simpson were used for α-diversity analysis. b-Diversity analysis was conducted using principal coordinate analysis (PCoA) and non-metric multidimensional scaling (NMDS) based on the Bray-Curtis distance...
2023: PeerJ
#9
JOURNAL ARTICLE
Dzhastyn Dkhillon, Alina Samogulova, Boris Kolobov
INTRODUCTION: Vitamin B deficiency causes cardiac hypertrophy, reduced cardiac contractility, and arrhythmias.The purpose of this study is to perform a network meta-analysis of randomized controlled trials of vitamin B supplements in a group of 150 patients who meet the eligibility criteria.The study also aims to describe the effect of synthetic multivitamins (pyridoxine, folic acid, and cyanocobalamin) on the laboratory findings reflecting the severity of chronic heart failure (cholesterol, glucose, and fibrinogen)...
2023: Cardiovascular & Hematological Disorders Drug Targets
#10
JOURNAL ARTICLE
Simon Hsu, Leila R Zelnick, Nisha Bansal, Julia Brown, Michelle Denburg, Harold I Feldman, Charles Ginsberg, Andrew N Hoofnagle, Tamara Isakova, Mary B Leonard, Benjamin Lidgard, Cassianne Robinson-Cohen, Myles Wolf, Dawei Xie, Bryan R Kestenbaum, Ian H de Boer
Background The ratio of 24,25-dihydroxyvitamin D3 /25-hydroxyvitamin D3 (vitamin D metabolite ratio [VDMR]) may reflect functional vitamin D activity. We examined associations of the VDMR, 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH]2 D) with cardiovascular disease (CVD) in patients with chronic kidney disease. Methods and Results This study included longitudinal and cross-sectional analyses of 1786 participants from the CRIC (Chronic Renal Insufficiency Cohort) Study. Serum 24,25-dihydroxyvitamin D3 , 25(OH)D, and 1,25(OH)2 D were measured by liquid chromatography-tandem mass spectrometry 1 year after enrollment...
July 8, 2023: Journal of the American Heart Association
#11
JOURNAL ARTICLE
Saleem Alenazi, Faisal Alqarni, Yara Aldajani, Abdullah Alzahrani, Mawada Ahmed
BACKGROUND Left ventricular thrombus is a serious complication of numerous cardiovascular conditions. Anticoagulation with oral vitamin K antagonists such as warfarin is a standard treatment for left ventricular thrombus and is recommended to reduce the risk of embolization. Patients with cardiac conditions share comorbidities with patients with end-stage renal disease, and patients with advanced kidney disease are predisposed to atherothrombotic and thromboembolic complications. The efficacy of direct oral anticoagulants in patients with left ventricular thrombus has not been well studied...
June 13, 2023: American Journal of Case Reports
#12
JOURNAL ARTICLE
Konstantinos Iliodromitis, Stylianos Tzeis, Anastasia Xintarakou, Vlasios Pyrgakis, Ioannis Zarifis, Sotirios Patsilinakos, Antonios Draganigos, Filippos Triposkiadis, George Hahalis, Athanasios Karanasios, Ioannis Goudevenos, Lampros Michalis, Charalampos Karvounis, Fraggiskos Parthenakis, Ioannis Kanakakis, Dimitrios Tousoulis, Efstathios Iliodromitis, Panos Vardas
PURPOSE: Atrial fibrillation (AF) and heart failure (HF) are common and commonly coexisting cardiovascular diseases in hospitalized patients. We report the absolute number and interrelation between AF and HF, assess the daily burden of both diseases on health-care system and report the medical treatment in a real world, nationwide conducted snapshot survey. METHODS: A questionnaire was equally distributed to various health care institutions. Baseline characteristics, prior hospitalizations and medical treatment of all hospitalized patients with AF and HF at a predefined date were collected and analyzed...
May 2, 2023: Hellenic Journal of Cardiology: HJC
#13
JOURNAL ARTICLE
Carla Rochira, Davide Capodanno
Despite the sharp decline in most high-income industrialized countries, rheumatic heart disease (RHD) continues to be highly prevalent in many rural, low- and middle-income countries. RHD most frequently involves the mitral valve, both in the form of isolated regurgitation and in the form of regurgitation associated with mitral stenosis (mitral stenosis, MS). Atrial fibrillation (AF) is a common complication of RHD that is independently associated with an increased risk of death, heart failure, and systemic thromboembolism...
April 2023: European Heart Journal Supplements: Journal of the European Society of Cardiology
#14
JOURNAL ARTICLE
Bo Guan, Xiao-Qiang Chen, Yan Liu, Hui Zhou, Ming-Yan Yang, Hong-Wei Zheng, Shi-Jun Li, Jian Cao
BACKGROUND: Observational studies suggest inverse associations between serum vitamin levels and the risk of heart failure (HF). However, the causal effects of vitamins on HF have not been fully elucidated. Here, we conducted a Mendelian randomization (MR) study to investigate the causal associations between genetically determined vitamin levels and HF. METHODS: Genetic instrumental variables for circulating vitamin levels, including vitamins A, B, C, D, and E, which were assessed as either absolute or metabolite levels were obtained from public genome-wide association studies...
March 28, 2023: Journal of Geriatric Cardiology: JGC
#15
JOURNAL ARTICLE
Robert Devich, Nina Rosa Neuendorff, Oscar Howard Frazier, Howard J Eisen, Robert Dowling, Miriam Freundt
The population presenting with cardiogenic shock is heterogenous. Anemia is common in advanced heart failure and associated with poor outcomes. Microaxial flow pumps may cause ongoing blood trauma and worsen anemia. Treatment with recombinant erythropoietin, iron, vitamin B, and folate is recommended before cardiac surgery to reduce perioperative transfusion requirements but no data exist on the feasibility and safety during support with microaxial flow pumps. This novel strategy was born out of necessity to support a Jehovah's Witness who opposes blood transfusion but required mechanical circulatory support...
August 1, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#16
JOURNAL ARTICLE
A A Surel, M K Çolakoğlu, E B Bostancı, O Erol
OBJECTIVE: Ascites is the pathological fluid accumulation in the peritoneal cavity and there are mainly two reasons for its etiology. These are malignant diseases such as hepatoma or pancreas cancer and benign diseases such as liver cirrhosis and heart failure. In this study, we investigated the diagnostic utility of arylesterase (ARES), paraoxonase (PON), stimulated paraoxonase (SPON), catalase (CAT) and myeloperoxidase (MPO) in the differential diagnosis of malignant and benign ascites...
April 2023: European Review for Medical and Pharmacological Sciences
#17
JOURNAL ARTICLE
M Samsonia, M Kandelaki, N Baratashvili, L Gvaramia
Direct critical attack of the coronavirus on the alveoli and the excessive release of a large number of cytokines (IL-6, IL-1, TNF-α, etc.) provides suitable conditions for the further development of acute respiratory distress syndrome (ARDS) and severe acute respiratory failure. Serious decrease in blood oxygenation often lead to the deterioration of macro- and microcirculation, irreversible brain damage and hence, persistent neurological and mental disorders despite background intensive therapy and adequate respiratory support...
February 2023: Georgian Medical News
#18
JOURNAL ARTICLE
F Sall, A Adoubi, C Boka, N Koffi, P Ouattara, A Dakoi, J B Anzouan-Kacou
BACKGROUND: The Post Discharge Management of patients with heart failure impact significantly their incomes. This study aims to analyze the clinical findings and management at the first medical visit of these patients in our context. MATERIAL AND METHODS: This is a retrospective cross-sectional descriptive study on consecutive files of patients hospitalized for heart failure from January to December 2018 in our Department. We analyse data from the first post discharge medical visit including medical visit time, clinical conditions and management...
February 20, 2023: BMC Cardiovascular Disorders
#19
JOURNAL ARTICLE
Felix Hofer, Andreas Hammer, Ulrike Pailer, Lorenz Koller, Niema Kazem, Eva Steinacher, Barbara Steinlechner, Martin Andreas, Günther Laufer, Johann Wojta, Thomas A Zelniker, Christian Hengstenberg, Alexander Niessner, Patrick Sulzgruber
Background Fibroblast growth factor 23 (FGF-23) is crucial in regulating phosphate and vitamin D metabolism and is moreover associated with an increased cardiovascular risk. The specific objective of this study was to investigate the influence of FGF-23 on cardiovascular outcomes, including hospitalization for heart failure (HHF), postoperative atrial fibrillation, and cardiovascular death, in an unselected patient population after cardiac surgery. Methods and Results Patients undergoing elective coronary artery bypass graft and/or cardiac valve surgery were prospectively enrolled...
March 7, 2023: Journal of the American Heart Association
#20
JOURNAL ARTICLE
Beata Uziȩbło-Życzkowska, Agnieszka Kapłon-Cieślicka, Monika Gawałko, Monika Budnik, Katarzyna Starzyk, Beata Wożakowska-Kapłon, Ludmiła Daniłowicz-Szymanowicz, Damian Kaufmann, Maciej Wójcik, Robert Błaszczyk, Jarosław Hiczkiewicz, Katarzyna Łojewska, Katarzyna Mizia-Stec, Maciej Wybraniec, Katarzyna Kosmalska, Marcin Fijałkowski, Anna Szymańska, Aleksandra Gos, Maciej Haberka, Michał Kucio, Błazej Michalski, Karolina Kupczyńska, Anna Tomaszuk-Kazberuk, Katarzyna Wilk-Śledziewska, Renata Wachnicka-Truty, Marek Koziński, Paweł Burchardt, Paweł Krzesiński
BACKGROUND: Our aim was to assess the characteristics and to identify predictors of left atrial thrombus (LAT) in patients under age 65 with atrial fibrillation (AF) or atrial flutter (AFl). METHODS: We conducted a subanalysis of a multicenter, prospective, observational study [the LATTEE registry]. Consecutive AF/AFl patients referred for cardioversion or ablation were enrolled. RESULTS: Of the 3,109 patients included in the study, 1,276 were under age 65 (41%)...
2022: Frontiers in Cardiovascular Medicine
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