Youstina Daoud, Farida Cheriet, Marie Beausejour, Philippe Debanne, Hubert Labelle
The customized design of braces for adolescent idiopathic scoliosis (AIS) treatment requires the acquisition of the 3D external geometry of the patients' trunks. Three body scanning systems are available at CHU Sainte-Justine in Montreal: a fixed system of InSpeck Capturor II LF digitizers and two portable scanners, BodyScan and Structure Sensor. The aim of this study is to compare them by evaluating their accuracy and repeatability. To achieve this, we placed 46 surface markers on an anthropomorphic manikin and scanned it three times with each system...
July 2020: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Xiang Wang, Qingchu Li, Jiali Cai, Wei Wang, Peng Xu, Yiqian Zhang, Qu Fang, Chicheng Fu, Li Fan, Yi Xiao, Shiyuan Liu
Background: Due to different treatment method and prognosis of different subtypes of lung adenocarcinomas appearing as ground-glass nodules (GGNs) on computed tomography (CT) scan, it is important to classify invasive adenocarcinomas from non-invasive adenocarcinomas. The purpose of this paper is to build and evaluate the performance of deep learning networks on the differentiation the invasiveness of lung adenocarcinoma appearing as GGNs. Methods: This retrospective study included 886 GGNs from 794 pathological confirmed patients with lung adenocarcinoma for training and testing the proposed networks...
August 2020: Translational Lung Cancer Research
Ruizhi Yuan, Neng Zhao, Babar Usman, Liang Luo, Shanyue Liao, Yufen Qin, Gul Nawaz, Rongbai Li
Common wild rice contains valuable resources of novel alleles for rice improvement. It is well known that genetic populations provide the basis for a wide range of genetic and genomic studies. In particular, chromosome segment substitution lines (CSSLs) ais a powerful tool for fine mapping of quantitative traits, new gene discovery and marker-assisted breeding. In this study, 132 CSSLs were developed from a cultivated rice ( Oryza sativa ) cultivar (93-11) and common wild rice ( Oryza rufipogon Griff. DP30) by selfing-crossing, backcrossing and marker-assisted selection (MAS)...
August 22, 2020: Genes
Giuseppina Augimeri, Giusi La Camera, Luca Gelsomino, Cinzia Giordano, Salvatore Panza, Diego Sisci, Catia Morelli, Balázs Győrffy, Daniela Bonofiglio, Sebastiano Andò, Ines Barone, Stefania Catalano
Aromatase inhibitors (AIs) represent the standard anti-hormonal therapy for post-menopausal estrogen receptor-positive breast cancer, but their efficacy is limited by the emergence of AI resistance (AIR ). Exosomes act as vehicles to engender cancer progression and drug resistance. The goal of this work was to study exosome contribution in AIR mechanisms, using estrogen-dependent MCF-7 breast cancer cells as models and MCF-7 LTED (Long-Term Estrogen Deprived) subline, modeling AIR . We found that exosome secretion was significantly increased in MCF-7 LTED cells compared to MCF-7 cells...
August 14, 2020: International Journal of Molecular Sciences
Ru Zhang, Li Zhu, Zhengqi Zhu, Yaqiong Ge, Zhongxin Zhang, Tianle Wang
BACKGROUND: Saving the ischemic penumbra (IP) is key in treating acute ischemic stroke (AIS). We aim to investigate the value of the apparent diffusion coefficient (ADC) map based radiomics model in the identification of IP in AIS. METHODS: This study retrospectively analyzed the data of 241 patients with AIS involving the anterior cerebral circulation who were treated in our hospital within 24 h of stroke onset from January 2014 to October 2019. With the perfusion-weighted imaging (PWI)/diffusion-weighted imaging (DWI) mismatch model as the gold standard to determine whether IP exists, we divided patients into PWI/DWI mismatch (84 cases) and non-PWI/DWI mismatch (157 cases)...
July 24, 2020: Annals of Palliative Medicine
Tihamer Molnar, Dorottya Csuka, Gabriella Pusch, Lajos Nagy, Peter Garred, Zsolt Illes
INTRODUCTION: Activation of both the L-arginine and the lectin pathway contributes to the pathophysiology and the outcome of acute ischemic stroke (AIS). However, the interplay between the two systems has not yet been examined. METHODS: A total of 44 patients with AIS were recruited into this study. Serial measurement of serum L-arginine, asymmetric and symmetric dimethylarginine (ADMA, SDMA), and hsCRP, ficolin-2, ficolin-3, MAP-1, MASP-3 and mannose-binding lectin (MBL) were analyzed within 6 h after onset of stroke and 72 h later...
August 2020: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Tianli Zhang, Xiaodong Zhang, Huisheng Sun, Feng Zhou, Shiqin Lin, Hui Sang, Nannan Zheng, Ziyi Zhao, Jing Shi, Weirong Li
OBJECTIVE: The Chinese stroke emergency map (SEM) was implemented in 2017 to reduce prehospital and hospital delays for acute ischemic stroke (AIS) patients suitable for intravenous recombinant tissue plasminogen activator (rt-PA) thrombolysis. However, data on the time delay following the implementation of an SEM in China are limited. METHODS: Data for suspected stroke patients from the SEM registry center of Taiyuan, Shanxi Province, from August 2017 to July 2019, patients' characteristics, thrombolysis rate, and functional outcome at 90 days were analyzed...
July 11, 2020: Brain and Behavior
Hulin Kuang, Bijoy K Menon, Wu Qiu
BACKGROUND AND OBJECTIVE: Stroke lesion volume is a key radiologic measurement in assessing prognosis of acute ischemic stroke (AIS) patients. The aim of this paper is to develop an automated segmentation method for accurately segmenting follow-up ischemic and hemorrhagic lesion from multislice non-contrast CT (NCCT) volumes of AIS patients. METHODS: This paper proposes a 2D dense multi-path contextual generative adversarial network (MPC-GAN) where a dense multi-path 2D U-Net is utilized as the generator and a discriminator network is applied to regularize the generator...
June 30, 2020: Physics in Medicine and Biology
Sushrut Fulare, Satish Deshmukh, Jyoti Gupta
BACKGROUND: Androgen Insensitivity Syndrome (AIS) is a rare X-linked recessive androgen receptor (AR) disorder with 46XY karyotype. Partial AIS affects 5-7 per 1,000,000 genetically male individuals whereas Complete AIS affects 2-5 per 100,000 genetically male individuals. CAIS CAIS is characterized by complete resistance to the action of androgens. PRESENTATION OF CASE: 17-year patient presented with swelling in bilateral inguinal region. Patient also complained of primary amenorrhea with serum FSH and LH levels being raised, serum testosterone level much above normal range...
February 6, 2020: International Journal of Surgery Case Reports
Adrian Farcas, Claire F Powell, Kate L Brookes, Nathan D Merchant
Underwater noise pollution from shipping is globally pervasive and has a range of adverse impacts on species which depend on sound, including marine mammals, sea turtles, fish, and many invertebrates. International bodies including United Nations agencies, the Arctic Council, and the European Union are beginning to address the issue at the policy level, but better evidence is needed to map levels of underwater noise pollution and the potential benefits of management measures such as ship-quieting regulations...
May 19, 2020: Science of the Total Environment
Dandan Feng, Rui Jia, Zhengliang Ma, Xiaoping Gu
OBJECTIVE: To explore risk factors for postoperative nausea and vomiting (PONV) that requires intervention with medications during adolescent idiopathic scoliosis (AIS) surgery. METHODS: We analyzed the data of 986 patients with AIS (including 156 male and 830 female patients) undergoing scoliosis surgery through a posterior approach between December, 2012 and January, 2016 in Nanjing Drum Tower Hospital. The data were collected from the patients including ASA grade, body mass index (BMI), Cobb angle, preoperative respiratory and cardiovascular diseases, operation time, type of anesthesia, quantity of intraoperative liquid infusion, blood loss, urine volume, the lowest MAP and CVP, intraoperative fentanyl consumption, and intraoperative administration of dexmedetomidine, dexamethasone, ondansetran and droperidol...
March 30, 2020: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Yuya Moroto, Keisuke Maeda, Takahiro Ogawa, Miki Haseyama
A few-shot personalized saliency prediction based on adaptive image selection considering object and visual attention is presented in this paper. Since general methods predicting personalized saliency maps (PSMs) need a large number of training images, the establishment of a theory using a small number of training images is needed. To tackle this problem, although finding persons who have visual attention similar to that of a target person is effective, all persons have to commonly gaze at many images. Thus, it becomes difficult and unrealistic when considering their burden...
April 11, 2020: Sensors
Chunguang Ren, Guangjun Xu, Yanchao Liu, Guoying Liu, Jinping Wang, Jian Gao
Background: Although several studies have compared conscious sedation (CS) with general anesthesia (GA) in patients undergoing mechanical thrombectomy (MT), there has been no affirmative conclusion. We conducted this trial to assess whether CS is superior to GA for patients undergoing MT for acute ischemic stroke (AIS). Methods: Acute ischemic stroke patients with anterior circulation large vascular occlusion were randomized into two groups. The primary outcome was modified Rankin scale score (0-2) at 90 days after stroke...
2020: Frontiers in Neurology
Jo Barnes, Kathryn L Loftis, Lauren Jones, Janet P Price, Patrick J Gillich, Kathy Cookman, Amy L Brammer, Trish St Germain, Vickie Graymire, Donna A Nayduch, Maureen Brennan
Objective: The objective of the mapping project was to develop an expert derived map between the International Statistical Classification of Diseases and Related Health Problems (ICD) clinical modifications (CM) and the Abbreviated Injury Scale (AIS) to be able to relate AIS severity to ICD coded data road traffic collision data in EU datasets. The maps were developed to enable the identification of serious AIS3+ injury and provide details of the mapping process for assumptions to be made about injury severity from mass datasets...
March 6, 2020: Traffic Injury Prevention
Ryan A Rava, Maxim Mokin, Kenneth V Snyder, Muhammad Waqas, Adnan H Siddiqui, Jason M Davies, Elad I Levy, Ciprian N Ionita
Purpose: Biomarkers related to hemodynamics can be quantified using angiographic parametric imaging (API), which is a quantitative imaging method that uses digital subtraction angiography (DSA). We aimed to assess the accuracy of API in locating infarct core within large vessel occlusion (LVO) acute ischemic stroke (AIS) patients. Approach: Data were retrospectively collected for 25 LVO AIS patients who achieved successful recanalization. DSA data from lateral and anteroposterior (AP) views were loaded into API software to generate hemodynamic parameter maps...
January 2020: Journal of Medical Imaging
Simone S Frassini, Shailvi S Gupta, Stefano S Granieri, Stefania S Cimbanassi, Fabrizio F Sammartano, Thomas M Scalea, Osvaldo O Chiara
BACKGROUND: Hemodynamically unstable pelvic fractures often require a multi-modal approach including both operative and endovascular management. While an important adjunct in hemorrhage control, time to angioembolization (AE) even at the most advanced trauma centers may take hours. Extra-Peritoneal Packing (EPP) is a fast and effective procedure that can immediately address pelvic hemorrhage from the retroperitoneal space in severe pelvic injuries. The aim of this study was to evaluate the efficacy of early EPP, looking at 24 hour and overall mortality, and the hemodynamic impact of EPP in unstable blunt pelvic trauma...
February 6, 2020: Journal of Trauma and Acute Care Surgery
Hamdan Hamdan, Brian C Lim, Tomohiro Torii, Abhijeet Joshi, Matthias Konning, Cameron Smith, Donna J Palmer, Philip Ng, Christophe Leterrier, Juan A Oses-Prieto, Alma L Burlingame, Matthew N Rasband
Axon initial segments (AISs) generate action potentials and regulate the polarized distribution of proteins, lipids, and organelles in neurons. While the mechanisms of AIS Na+ and K+ channel clustering are understood, the molecular mechanisms that stabilize the AIS and control neuronal polarity remain obscure. Here, we use proximity biotinylation and mass spectrometry to identify the AIS proteome. We target the biotin-ligase BirA* to the AIS by generating fusion proteins of BirA* with NF186, Ndel1, and Trim46; these chimeras map the molecular organization of AIS intracellular membrane, cytosolic, and microtubule compartments...
January 3, 2020: Nature Communications
Martin Bretzner, Renaud Lopes, Ray McCarthy, Delphine Corseaux, Florent Auger, Gillian Gunning, Nicolas Beauval, Antonino Bongiovanni, Meryem Tardivel, Charlotte Cordonnier, Jean-Pierre Pruvo, Sophie Susen, Xavier Leclerc, Grégory Kuchcinski
BACKGROUND AND PURPOSE: Previous studies have suggested that mechanical revascularization in acute ischemic stroke (AIS) patients could be affected by clot histology. In this 7-T micro-MRI study, we used R2* relaxometry of clot analogs to evaluate the relationship between texture parameters of R2* maps and clot constituents. MATERIALS AND METHODS: Twelve AIS clot analogs were experimentally generated to obtain a wide range of red blood cell concentrations. All clots underwent a MR acquisition using a 7-T micro-MR system...
November 11, 2019: Journal of Neuroradiology. Journal de Neuroradiologie
Shanchao Zhang, Xia Zhao, Shan Xu, Jing Yuan, Zhihua Si, Yang Yang, Shan Qiao, Xuxu Xu, Aihua Wang
BACKGROUD: Patients with acute ischemic stroke (AIS) often experience low serum free triiodothyronine (FT3), but the association of low FT3 with stroke severity, subtype and prognosis has not yet been thoroughly studied, and the molecular events underlying these clinical observation were also unclear. METHODS: We retrospectively collected 221 cases of AIS and 182 non-AIS cases with detailed clinical data from our department. FT3 concentrations were measured on admission to predict functional outcome within 3 months using multivariable models adjusted for other risk factors...
November 5, 2019: BMC Neurology
Annika B Kay, David S Morris, Dave S Collingridge, Sarah Majercik
BACKGROUND: Platelet dysfunction associated with isolated traumatic brain injury (TBI) can be measured using thromboelastography-platelet mapping (TEG-PM). We hypothesized that platelet dysfunction can be detected after blunt TBI, and the degree of dysfunction is associated with increased TBI severity and in-hospital mortality. METHODS: This was a retrospective review of adult trauma patients admitted to a single level 1 trauma center from August 2013 to March 2015 who suffered isolated severe blunt TBI...
September 23, 2019: American Journal of Surgery
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