Jeong-Yun Lee, Grace J Lee, Ayumi Nakamura, Pa Reum Lee, Yeajin Kim, Chan Hee Won, Hidemasa Furue, Seog Bae Oh
The endocannabinoid system (ECS) is known to modulate not only food intake but also pain, especially via the cannabinoid type 1 receptor (CB1R) expressed throughout the central nervous system and the peripheral tissues. Our previous study demonstrated that fasting produces an analgesic effect in adult male mice, which is reversed by intraperitoneal (i.p.) administration of CB1R antagonist (SR 141716). In the present study, we further examined the effect of CB1R expressed in the peripheral tissues. In the formalin-induced inflammatory pain model, i...
January 2020: Molecular Pain