Cecilia T Costiniuk, Terry Lee, Joel Singer, Yannick Galipeau, Corey Arnold, Marc-André Langlois, Judy Needham, Mohammad-Ali Jenabian, Ann N Burchell, Hasina Samji, Catharine Chambers, Sharon Walmsley, Mario Ostrowski, Colin Kovacs, Darrell H S Tan, Marianne Harris, Mark Hull, Zabrina L Brumme, Hope R Lapointe, Mark A Brockman, Shari Margolese, Enrico Mandarino, Suzanne Samarani, Bertrand Lebouché, Jonathan B Angel, Jean-Pierre Routy, Curtis L Cooper, Aslam H Anis
COVID-19 breakthrough infection (BTI) can occur despite vaccination. Using a multi-centre, prospective, observational Canadian cohort of people with HIV (PWH) receiving ≥2 COVID-19 vaccines, we compared the SARS-CoV-2 spike (S) and receptor-binding domain (RBD)-specific IgG levels 3 and 6 months post second dose, as well as 1 month post third dose, in PWH with and without BTI. BTI was defined as positivity based on self-report measures (data up to last study visit) or IgG data (up to 1 month post dose 3)...
April 23, 2024: Vaccines