Emmanouil Mavrogeorgis, Margarita Kondyli, Harald Mischak, Antonia Vlahou, Justyna Siwy, Peter Rossing, Archie Campbell, Carina M C Mels, Christian Delles, Jan A Staessen, Agnieszka Latosinska, Alexandre Persu
OBJECTIVES: Hypertension is a common condition worldwide; however, its underlying mechanisms remain largely unknown. This study aimed to identify urinary peptides associated with hypertension to further explore the relevant molecular pathophysiology. METHODS: Peptidome data from 2876 individuals without end-organ damage were retrieved from the Human Urinary Proteome Database: general population (discovery) or type 2 diabetic (validation) cohorts. Participants were divided based on systolic blood pressure (SBP) and diastolic BP (DBP) into hypertensive (SBP ≥140 mmHg and/or DBP ≥90 mmHg) and normotensive (SBP <120 mmHg and DBP <80 mmHg, without antihypertensive treatment) groups...
March 29, 2024: Journal of Hypertension