Joaquín García-Luna, Florencia Rivero-Osorio, María Clara González-Porcile, Paula Arbildi, Sebastián Miles, Javier Magnone, María Velasco-De-Andrés, Sylvia Dematteis, Francisco Lozano, Gustavo Mourglia-Ettlin
Scavenger receptors participate in a wide range of biological functions after binding to multiple non-self or altered self-ligands. Among them, CD5 and CD6 are lymphocyte scavenger receptors known to interact with different microbial-associated molecular patterns, and the administration of the recombinant soluble ectodomains of human CD5 (rshCD5) and/or CD6 (rshCD6) has shown therapeutic/prophylactic potential in experimental models of fungal, bacterial and echinococcal infections. The latter is a zoonosis caused by the larval stage of the cestode parasite Echinococcus granulosus sensu lato, which in humans can induce secondary cystic echinococcosis (CE) after the spillage of protoscoleces contained within fertile cysts, either spontaneously or during surgical removal of primary hydatid cysts...
April 2024: Parasite Immunology