Vasily N Sukhorukov, Victoria A Khotina, Daria D Borodko, Mariam Bagheri Ekta, Yumiko Oishi, Andrey V Omelchenko, Kira I Kolmychkova, Nikita G Nikiforov, Igor A Sobenin, Alexander N Orekhov
BACKGROUND: The relationship between the cellular pro-inflammatory response and intracellular lipid accumulation in atherosclerosis is not sufficiently studied. Transcriptomic analysis is one way to establish such a relationship. Previously, we identified 10 potential key genes (IL-15, CXCL8, PERK, IL-7, IL-7R, DUSP1, TIGIT, F2RL1, TSPYL2, and ANXA1) involved in cholesterol accumulation in macrophages. It should be noted that all these genes do not directly participate in cholesterol metabolism, but encode molecules related to inflammation...
February 19, 2024: Current Medicinal Chemistry