Yusuke Toyohara, Ayumi Taguchi, Yoshiyuki Ishii, Daisuke Yoshimoto, Miki Yamazaki, Hiroko Matsunaga, Kazuma Nakatani, Daisuke Hoshi, Saki Tsuchimochi, Misako Kusakabe, Satoshi Baba, Akira Kawata, Masako Ikemura, Michihiro Tanikawa, Kenbun Sone, Mayuyo Uchino-Mori, Tetsuo Ushiku, Haruko Takeyama, Katsutoshi Oda, Kei Kawana, Yoshitaka Hippo, Yutaka Osuga
Human papillomavirus 18 (HPV18) is a highly malignant HPV genotype among high-risk HPVs, characterized by the difficulty of detecting it in precancerous lesions and its high prevalence in adenocarcinomas. The cellular targets and molecular mechanisms underlying its infection remain unclear. In this study, we aimed to identify the cells targeted by HPV18 and elucidate the molecular mechanisms underlying HPV18 replication. Initially, we established a lentiviral vector (HPV18LCR-GFP vector) containing the HPV18 long control region promoter located upstream of EGFP...
November 23, 2023: Cancer Science