Chirag Dhar, Prasanna Ramachandran, Gege Xu, Chad Pickering, Tomislav Čaval, Maurice Wong, Rachel Rice, Bo Zhou, Apoorva Srinivasan, Paul Aiyetan, Chih-Wei Chu, Kaitlyn Moser, Thomas J Herzog, Alexander Babatunde Olawaiye, Francis Jacob, Daniel Serie, Klaus Lindpaintner, Flavio Schwarz
BACKGROUND: There is a need for diagnostic tests for screening, triaging and staging of epithelial ovarian cancer (EOC). Glycoproteomics of blood samples has shown promise for biomarker discovery. METHODS: We applied glycoproteomics to serum of people with EOC or benign pelvic masses and healthy controls. A total of 653 analytes were quantified and assessed in multivariable models, which were tested in an independent cohort. Additionally, we analyzed glycosylation patterns in serum markers and in tissues...
April 24, 2024: British Journal of Cancer