Kristina Jakic, Michal Selc, Filip Razga, Veronika Nemethova, Petra Mazancova, Filip Havel, Michal Sramek, Monika Zarska, Jan Proska, Vlasta Masanova, Iveta Uhnakova, Peter Makovicky, Marta Novotova, Vit Vykoukal, Andrea Babelova
INTRODUCTION: Gold nanoparticles are promising candidates as vehicles for drug delivery systems and could be developed into effective anticancer treatments. However, concerns about their safety need to be identified, addressed, and satisfactorily answered. Although gold nanoparticles are considered biocompatible and nontoxic, most of the toxicology evidence originates from in vitro studies, which may not reflect the responses in complex living organisms. METHODS: We used an animal model to study the long-term effects of 20 nm spherical AuNPs coated with bovine serum albumin...
2024: International Journal of Nanomedicine