Chang Hyeon Kong, Hoo Sik Min, Mijin Jeon, Woo Chang Kang, Keontae Park, Min Seo Kim, Seo Yun Jung, Ho Jung Bae, Se Jin Park, Hyeon-Kyoo Shin, Chang-Seob Seo, Jong Hoon Ryu
ETHNOPHARMACOLOGICAL RELEVANCE: Cheonwangbosimdan (CWBSD), an herbal medicine traditionally used for anxiety, insomnia, depression, and heart palpitations, has been reported to have anti-anxiety, antidepressant, cognitive improvement, and neuroprotective effects. AIM OF THE STUDY: The purpose of this study was to determine if CWBSD could affect post-traumatic stress disorder (PTSD)-like behaviors because it has prioritized clinical use over mechanism study. MATERIALS AND METHODS: A single prolonged stress (SPS) mouse model, a well-established animal model of PTSD, was used to investigate whether standardized CWBSD could mitigate PTSD-like behaviors through robust behavioral tests, including the elevated plus-maze test and marble burying test for measuring anxiety-like behaviors, the splash test, forced swimming test, and tail suspension test for evaluating depression-like behaviors, and the Y-maze test and novel object recognition test for assessing cognitive function...
April 27, 2024: Journal of Ethnopharmacology