keyword
https://read.qxmd.com/read/38686391/effect-of-vitamin-d-supplementation-on-muscle-function-in-patients-with-i131-induced-hypothyroidism-a-pilot-randomized-trial
#1
JOURNAL ARTICLE
Sureephan Maneewan, Worapaka Manosroi, Panas Jesadaporn, Mattabhorn Phimphilai, Pratchaya Tipduangta
BACKGROUND: There is a lack of data regarding the effect of vitamin D supplements in patients with I131-induced hypothyroidism. The primary aim of this study was to investigate the effect of vitamin D supplements on muscle function, and the secondary aim was to observe the effect on body composition, insulin resistance, and quality of life (QOL) in patients with I131-induced hypothyroidism. METHODS: In this pilot randomized placebo-controlled trial, patients with I131-induced hypothyroidism on a stable dose of levothyroxine were enrolled and allocated into 2 groups to receive oral vitamin D 20 000 IU weekly or placebo for 24 weeks...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38676741/levothyroxine-for-subclinical-hypothyroidism-during-pregnancy-an-updated-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Henrique Provinciatto, Marcus Vinicius Barbosa Moreira, Gabriel Rezende Neves, Lucas Rezende De Freitas, Henrique Costa Mitsui, Julio Min Fei Zhang, Edward Araujo Júnior
PURPOSE: We aimed to perform a systematic review and meta-analysis addressing the efficacy of levothyroxine therapy in pregnant women with subclinical hypothyroidism considering most recent evidence and subgroups of interest for clinical practice. METHODS: PubMed, Embase, and Cochrane Central were searched from inception for randomized controlled trials (RCTs) comparing levothyroxine with placebo or no intervention in pregnant women with subclinical hypothyroidism...
April 27, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38661527/patient-reported-satisfaction-with-thyroid-hormone-replacement-therapy-for-subclinical-hypothyroidism-in-older-adults-a-pooled-analysis-of-individual-participant-data-from-two-randomized-controlled-trials
#3
JOURNAL ARTICLE
Janneke Ravensberg, Rosalinde K E Poortvliet, Robert Du Puy, Nicolas Rodondi, Manuel Blum, Patricia Kearney, Vera J C Mc Carthy, Terry Quinn, Olaf Dekkers, Wouter Jukema, Simon Mooijaart, Jacobijn Gussekloo
Background The benefit of levothyroxine treatment of subclinical hypothyroidism (SCH) is subject to debate. This study compared treatment satisfaction between older adults with SCH using levothyroxine or placebo. Methods We analyzed pooled individual participant data from two randomized, double-blind, placebo-controlled trials investigating the effects of levothyroxine treatment in older adults with SCH. Community-dwelling participants aged ≥65 years, with SCH (persistent thyrotropin levels 4.60-19.99 mIU/L for >3 months and normal free thyroxine level) were included...
April 25, 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/38657019/efficacy-of-a-telemonitoring-system-as-a-complementary-strategy-in-the-treatment-of-patients-with-heart-failure-randomized-clinical-trial
#4
JOURNAL ARTICLE
Diana M Achury-Saldaña, Rafael A Gonzalez, Angel Garcia, Alejandro Mariño, Wilson R Bohorquez
Episodes of decompensation are the main cause of hospital admissions in patients with heart failure. For this reason, the use of mobile apps emerges as an excellent strategy to improve coverage, real-time monitoring, and timeliness of care. ControlVit is an electronic application for early detection of complications studied within the context of a tertiary university hospital. Patients were randomized to the use of ControlVit versus placebo, during a 6-month follow-up. The primary outcome was the difference in numbers of readmissions and deaths for heart failure between both groups...
April 24, 2024: Computers, Informatics, Nursing: CIN
https://read.qxmd.com/read/38622434/interventions-to-improve-symptomatology-in-patients-with-hypothyroidism-and-persistent-symptoms-a-systematic-review
#5
JOURNAL ARTICLE
Jessica Hidalgo, Eddy P Lincango, Sandra Cordova-Madera, Kim Ruiz-Arellanos, Camila Wenczenovicz, Oscar Ponce, Neri Álvarez-Villalobos, Arbaaz Rao, Naykky M Singh Ospina, Spyridoula Maraka, Gonzalo J Acosta, Juan P Brito
BACKGROUND: Levothyroxine (LT4) monotherapy is the standard treatment for hypothyroidism; however, 10-15% of patients have persistent hypothyroid symptoms despite normalizing thyroid hormone levels with LT4. This study aims to summarize the best available evidence on interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms. METHODS: A systematic search was conducted in March 2022 for randomized controlled trials and observational studies on interventions for adult patients with persistent hypothyroid symptoms despite biochemical euthyroidism on thyroid hormone replacement...
April 15, 2024: Endocrine
https://read.qxmd.com/read/38581169/a-systematic-review-of-treatment-related-adverse-events-for-combination-therapy-of-multiple-tyrosine-kinase-inhibitor-and-immune-checkpoint-inhibitor
#6
JOURNAL ARTICLE
Takashi Sawada, Mamoru Narukawa
BACKGROUND: Combination therapy with multiple tyrosine kinase inhibitors (multi-TKIs) and immune checkpoint inhibitors (ICIs) has been increasingly tested in clinical studies. This study aimed to investigate the effect of the addition of ICI to multi-TKIs on the profile of treatment-related adverse events. METHODS: An electronic database search was performed using PubMed and Web of Science to identify published clinical studies on multi-TKI monotherapy and multi-TKI plus ICI combination therapy from July 20, 2005 to July 1, 2023...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38537636/effects-of-levothyroxine-in-subclinical-hypothyroidism-and-heart-failure-with-reduced-ejection-fraction-an-open-label-randomized-trial
#7
JOURNAL ARTICLE
Wenyao Wang, Xuan Zhang, Jun Gao, Xiangbin Meng, Jingjia Wang, Kuo Zhang, Jing Chen, Jiating Qi, Chunli Shao, Yi-Da Tang
We report a randomized, multicenter, open-label trial (ClinicalTrials.gov: NCT03096613) to investigate the clinical benefits of levothyroxine (L-T4) administration in subclinical hypothyroidism (SCH) patients with heart failure with reduced ejection fraction (HFrEF). Overall, 117 patients were enrolled and received L-T4 plus standard HFrEF treatment (experimental group, N = 57) or standard HFrEF therapy alone (control group, N = 60). The change of 6-min walk test distance in the experimental group was significantly higher than that in the control group at 24 weeks (70...
March 22, 2024: Cell reports medicine
https://read.qxmd.com/read/38526391/potential-risks-and-benefits-of-desiccated-thyroid-extract-for-the-treatment-of-hypothyroidism-a-systematic-review
#8
JOURNAL ARTICLE
Kamilla Ryom Riis, Camilla Bøgelund Larsen, Steen Joop Bonnema
BACKGROUND: Desiccated thyroid extract (DTE) is no longer recommended for treatment of hypothyroidism but is still in use. This review aimed to summarize the available literature on treatment with DTE in adult hypothyroid patients. METHODS: The search was conducted up until the 6th of January 2024 in six electronic databases. Two reviewers independently screened all search results. The retrieved studies compared DTE treatment with levothyroxine or combination therapy with liothyronine and levothyroxine...
March 25, 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/38518592/immune-related-adverse-events-associated-with-first-line-immune-checkpoint-inhibitors-for-metastatic-renal-cell-carcinoma-a-systematic-review-and-network-meta-analysis
#9
REVIEW
Shan Wang, Hongwei Lv, Jing Yu, Miao Chen
BACKGROUND: In the realm of metastatic renal cell carcinoma (mRCC), the introduction of immune checkpoint inhibitors (ICIs) has revolutionized treatment paradigms. Despite their effectiveness, the comprehensive safety profile of these therapies remains inadequately explored. This network meta-analysis aims to comparing the safety profiles of ICI-based treatments in mRCC, offering vital insights that could lead to the optimization of treatment strategies and improvement of patient care...
March 21, 2024: International Immunopharmacology
https://read.qxmd.com/read/38516099/sintilimab-plus-anlotinib-as-second-or-further-line-therapy-for-extensive-disease-small-cell-lung-cancer-a-phase-2-investigator-initiated-non-randomized-controlled-trial
#10
JOURNAL ARTICLE
Shuxiang Ma, Zhen He, Yang Liu, Lili Wang, Sen Yang, Yufeng Wu, Haiyang Chen, Yingxi Wu, Qiming Wang
BACKGROUND: Treatment options remain rather limited for extensive disease small cell lung cancer (ED-SCLC) patients in second or further-line setting. METHODS: The phase 2 investigator-initiated non-randomized study enrolled patients who had disease progression on at least one line of platinum-based chemotherapy. Participants received intravenous sintilimab 200 mg on day one and oral daily anlotinib 12 mg on days 1-14 once every three weeks per cycle. The primary endpoint was progression-free survival (PFS)...
April 2024: EClinicalMedicine
https://read.qxmd.com/read/38507967/effects-of-yoga-on-hypothyroidism-a-systematic-review
#11
REVIEW
Abhijit Baishya, Kashinath Metri
Evidence from clinical trials has shown positive effects of yoga on hypothyroidism. To date, there is no review of these studies. This systematic review evaluates the efficacy of yoga as a therapeutic intervention for hypothyroidism. PubMed, Medline, PsycINFO, and Science Direct databases were searched to identify relevant literature. The review included clinical studies that evaluated the effects of yoga on hypothyroidism. Studies that were not conducted inenglish, unavailable, non-experimental, or those that were reviews, case studies, case reports, not based on yoga, involved yoga as a intervention, or included a mixed population were excluded...
March 19, 2024: Journal of Ayurveda and Integrative Medicine
https://read.qxmd.com/read/38470079/evaluation-of-efficacy-and-safety-of-vitiligo-treatment-with-micro-needling-combined-with-n-acetylcysteine-and-micro-needling-alone-a-double-blinded-randomized-controlled-clinical-trial
#12
JOURNAL ARTICLE
Najmolsadat Atefi, Elham Ziaeifar, Farnoosh Seirafianpour, Afsaneh Sadeghzadeh-Bazargan, Nazila Ghoreishi Amin, Samaneh Mozafarpoor, Abolfazl Abouie, Mohammad Amin Jafari, Azadeh Goodarzi
INTRODUCTION: Vitiligo is a skin pigmentation disorder caused by the selective degradation of melanocytes. This study investigates the therapeutic effects of microneedling with and without N-acetylcysteine (NAC) in patients with persistent and limited vitiligo. METHOD: This research employed a clinical trial design with double-blind randomization. Individuals affected by vitiligo and seeking treatment at Rasool Akram Medical Complex were divided into two separate treatment groups...
March 12, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38420579/acupuncture-treatment-for-hashimoto-s-thyroiditis-an-exploratory-randomized-controlled-trial
#13
JOURNAL ARTICLE
Shanze Wang, Chao Yang, Weimei Zeng, Hongfang Tian, Shihao Du, Jiping Zhao
BACKGROUND: Hashimoto's thyroiditis (HT) has a high incidence rate and unresolved clinical symptoms. Although Hand Yangming Meridian Penetrating Acupuncture has been used to treat thyroid diseases in China, there is no randomized controlled trial (RCT) on HT. METHODS: This exploratory RCT aims to preliminarily evaluate the efficacy, safety, and feasibility of Hand Yangming Meridian Penetrating Acupuncture in the treatment of HT. Included subjects were randomly assigned to the acupuncture group and the waiting treatment group at a ratio of 1:1...
March 2024: Integrative Medicine Research
https://read.qxmd.com/read/38368537/effects-of-levothyroxine-treatment-on-fertility-and-pregnancy-outcomes-in-subclinical-hypothyroidism-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
JOURNAL ARTICLE
Akiko Sankoda, Hitomi Suzuki, Misa Imaizumi, Ai Yoshihara, Sakiko Kobayashi, Miyuki Katai, Katsuhiko Hamada, Yoh Hidaka, Aya Yoshihara, Hannah Nakamura, Sumihisa Kubota, Maiko Kakita-Kobayashi, Akira Iwase, Takashi Sugiyama, Erika Ota, Naoko Arata
Background: Subclinical hypothyroidism, defined by elevated thyrotropin (TSH) and normal free thyroxine levels, is associated with adverse pregnancy outcomes, including preterm birth, pre-eclampsia, and small for gestational age. Despite the uncertainty regarding the effectiveness of levothyroxine (LT4) treatment on pregnancy outcomes in subclinical hypothyroidism, LT4 is widely administered with a pre-treatment threshold TSH level of 2.5 mU/L. The aim of this study is to investigate the efficacy of periconceptional LT4 treatment for subclinical hypothyroidism, including TSH levels >2...
April 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/38294680/the-effect-of-different-levothyroxine-administration-regimens-on-thyroid-hormone-levels-a-systematic-review-pairwise-and-network-meta-analysis
#15
REVIEW
Bianca Vendruscolo Bianchini, Patricia Romualdo de Jesus, Renato Gorga Bandeira de Mello, Patricia Klarmann Ziegelmann, Kristian Bellevue Filion, Tatiane da Silva Dal Pizzol
INTRODUCTION: This systematic review aimed to compare the effect of alternative levothyroxine administration regimens on thyroid hormone levels and patient-reported outcomes (PROs) among adults with hypothyroidism. METHODS: We searched PubMed, Embase, CENTRAL, CINAHL, LILACS, SciELO, Scopus, Web of Science, OpenGrey, ProQuest, ClinicalTrials.gov, and ICTRP from inception to May/2023 for randomized controlled trials (RCTs). We assessed the risk of bias with Cochrane Risk of Bias 2...
March 2024: Expert Review of Clinical Pharmacology
https://read.qxmd.com/read/38247574/effect-of-cognitive-behavior-therapy-based-on-the-health-education-pathway-on-psychology-of-papillary-thyroid-carcinoma-patients-a-randomized-controlled-trial
#16
JOURNAL ARTICLE
Chunyan Zhao, Wei Diao, Xin Xu, Lin Li, Zhiyun Jia
OBJECTIVES: Our main aim was to explore whether cognitive behavior therapy based on the health education pathway (CBT-HEP) can effectively alleviate the distress, anxiety, and depression of papillary thyroid carcinoma (PTC) patients after 131I treatment. In addition, we investigated the critical factors that can significantly affect the distress and quality of life in PTC patients before 131I treatment. METHODS: In total, 496 people were screened and 357 were enrolled, followed by randomization of those with a distress thermometer (DT) ≥4...
January 22, 2024: Nuclear Medicine Communications
https://read.qxmd.com/read/38243784/selenium-supplementation-in-patients-with-hashimoto-thyroiditis-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#17
JOURNAL ARTICLE
Valentina Viola Huwiler, Stephanie Maissen-Abgottspon, Zeno Stanga, Stefan Muehlebach, Roman Trepp, Lia Bally, Arjola Bano
BACKGROUND: Hashimoto thyroiditis (HT) is the most common cause of hypothyroidism in iodine-sufficient areas. Selenium is an essential trace element required for thyroid hormone synthesis and exerts antioxidant effects. Therefore, it may be of relevance in the management of HT. METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of selenium supplementation on thyroid function (thyroid-stimulating hormones [TSH], free and total thyroxine [fT4, T4], free and total triiodothyronine [fT3, T3]), thyroid antibodies (thyroid peroxidase [TPOAb], thyroglobulin [TGAb], thyrotropin receptor [TRAb]), ultrasound findings (echogenicity, thyroid volume), immune markers, patient-reported outcomes, and adverse events in HT...
January 20, 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/38228158/association-of-mild-iodine-insufficiency-during-pregnancy-with-child-neurodevelopment-in-patients-with-subclinical-hypothyroidism-or-hypothyroxinemia
#18
JOURNAL ARTICLE
Brian M Casey, Lisa Mele, Alan M Peaceman, Michael W Varner, Uma M Reddy, Ronald J Wapner, John M Thorp, George R Saade, Alan T N Tita, Dwight J Rouse, Baha M Sibai, Maged M Costantine, Brian M Mercer, Steve N Caritis
OBJECTIVE:  Our objective was to evaluate whether iodine status in pregnant patients with either subclinical hypothyroidism or hypothyroxinemia in the first half of pregnancy is associated with measures of behavior and neurodevelopment in children through the age of 5 years. STUDY DESIGN:  This is a secondary analysis of a multicenter study consisting of two randomized, double-masked, placebo-controlled treatment trials conducted in parallel. Patients with a singleton gestation before 20 weeks' gestation underwent thyroid screening using serum thyrotropin and free thyroxine...
January 16, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38206745/effects-of-vitamin-d-supplementation-on-autoantibodies-and-thyroid-function-in-patients-with-hashimoto-s-thyroiditis-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Jiahao Tang, Shuanghong Shan, Fangping Li, Peng Yun
BACKGROUND: Hashimoto's thyroiditis (HT) is the prevailing form of autoimmune thyroiditis and the leading cause of hypothyroidism in iodine-sufficient regions worldwide. This study aims to evaluate the efficacy of vitamin D supplementation on HT through a meta-analysis of randomized controlled trials (RCTs). METHODS: The databases searched included PubMed, and others. We included RCTs that the treatment group received vitamin D, while the control group received either a placebo or no treatment...
December 29, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38201918/subclinical-hypothyroidism-in-patients-with-obesity-and-metabolic-syndrome-a-narrative-review
#20
REVIEW
Bernadette Biondi
The literature on the connection between obesity, metabolic syndrome, and subclinical hypothyroidism is critically analyzed in this narrative review. These conditions are frequently observed among adult populations and various studies and meta-analyses have assessed their association. The prevalence of subclinical hypothyroidism in obese individuals is higher than in non-obese subjects and this trend is more pronounced in unhealthy obesity phenotypes. However, the diagnosis and treatment of subclinical hypothyroidism can be difficult in obese patients...
December 27, 2023: Nutrients
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