Joseph Akoi Boré, Joseph W S Timothy, Tom Tipton, Ifono Kekoura, Yper Hall, Grace Hood, Stephanie Longet, Kimberly Fornace, Millimono S Lucien, Sarah Katarina Fehling, Beatrice K Koivogui, Si'Ana A Coggins, Eric D Laing, Christopher C Broder, N' Faly Magassouba, Thomas Strecker, Jeremy Rossman, Kader Konde, Miles W Carroll
Human Ebola virus (EBOV) outbreaks caused by persistent EBOV infection raises questions on the role of zoonotic spillover in filovirus epidemiology. To characterise filovirus zoonotic exposure, we collected cross-sectional serum samples from bushmeat hunters (n = 498) in Macenta Prefecture Guinea, adjacent to the index site of the 2013 EBOV-Makona spillover event. We identified distinct immune signatures (20/498, 4.0%) to multiple EBOV antigens (GP, NP, VP40) using stepwise ELISA and Western blot analysis and, live EBOV neutralisation (5/20; 25%)...
May 16, 2024: Nature Communications