Tianming Lu, Lirun Zhou, Zheng Chu, Yang Song, Qixin Wang, Minghong Zhao, Chuanhao Dai, Lin Chen, Guangqing Cheng, Jigang Wang, Qiuyan Guo
OBJECTIVE: To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). METHODS: We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. RESULTS: C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase)...
March 25, 2024: Chinese Medicine