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RANDOMIZED CONTROLLED TRIAL
Howard A Burris, Takuji Okusaka, Arndt Vogel, Myung Ah Lee, Hidenori Takahashi, Valeriy Breder, Jean-Frédéric Blanc, Junhe Li, Melinda Bachini, Magdalena Żotkiewicz, Jayne Abraham, Nikunj Patel, Julie Wang, Muzammil Ali, Nana Rokutanda, Gordon Cohen, Do-Youn Oh
BACKGROUND: In the ongoing, randomised, double-blind phase 3 TOPAZ-1 study, durvalumab, a PD-L1 inhibitor, plus gemcitabine and cisplatin was associated with significant improvements in overall survival compared with placebo, gemcitabine, and cisplatin in people with advanced biliary tract cancer at the pre-planned intermin analysis. In this paper, we present patient-reported outcomes from TOPAZ-1. METHODS: In TOPAZ-1 (NCT03875235), participants aged 18 years or older with previously untreated, unresectable, locally advanced, or metastatic biliary tract cancer with an Eastern Cooperative Oncology Group performance status of 0 or 1 and one or more measurable lesions per Response Evaluation Criteria in Solid Tumors (RECIST; version 1...
May 2024: Lancet Oncology
#2
JOURNAL ARTICLE
Y Suari, T Topaz, O Bassa, M Gilboa, H Zedaka, T Sade, B Chefetz, G Yahel
Estuaries are a significant source of nutrients to the marine environment. The magnitude of this source is a function of nutrients load reaching the estuary and removal (attenuation) within estuaries. Most estuarine research is conducted in large estuaries, which do not reflect the processes in small estuaries in urban and semi-arid regions where flood water is a substantial portion of the annual discharge and the estuarine baseflow is often low and dominated by wastewater. To improve the understanding of nutrient attenuation and load into the Mediterranean, we conducted high-resolution nutrient sampling in the eutrophic Alexander micro-estuary as a test case...
April 29, 2024: Science of the Total Environment
#3
JOURNAL ARTICLE
Margherita Rimini, Gianluca Masi, Sara Lonardi, Federico Nichetti, Tiziana Pressiani, Daniele Lavacchi, Lucchetti Jessica, Guido Giordano, Mario Scartozzi, Emiliano Tamburini, Alessandro Pastorino, Ilario Giovanni Rapposelli, Bruno Daniele, Erika Martinelli, Ingrid Garajova, Giuseppe Aprile, Marta Schirripa, Vincenzo Formica, Francesca Salani, Costanza Winchler, Francesca Bergamo, Rita Balsano, Eleonora Gusmaroli, Angotti Lorenzo, Matteo Landriscina, Andrea Pretta, Ilaria Toma, Chiara Pirrone, Anna Diana, Francesco Leone, Oronzo Brunetti, Giovanni Brandi, Silvio Ken Garattini, Maria Antonietta Satolli, Federico Rossari, Lorenzo Fornaro, Monica Niger, Valentina Zanuso, Antonio De Rosa, Francesca Ratti, Luca Aldrighetti, Filippo De Braud, Silvia Foti, Mario Domenico Rizzato, Caterina Vivaldi, Cascinu Stefano, Lorenza Rimassa, Lorenzo Antonuzzo, Andrea Casadei-Gardini
BACKGROUND: The TOPAZ-1 phase III trial reported a survival benefit with the anti-programmed cell death ligand 1 (anti-PD-L1) durvalumab in combination with gemcitabine and cisplatin in patients with advanced biliary tract cancer (BTC). OBJECTIVE: The present study investigated for the first time the impact on survival of adding durvalumab to cisplatin/gemcitabine compared with cisplatin/gemcitabine in a real-world setting. PATIENTS AND METHODS: The analyzed population included patients with unresectable, locally advanced, or metastatic BTC treated with durvalumab in combination with cisplatin/gemcitabine or with cisplatin/gemcitabine alone...
May 1, 2024: Targeted Oncology
#4
JOURNAL ARTICLE
Jun Rui Don Koh, Charles Kam King Kon, S B M Darshana Chandrakumara
Haglund's deformity refers to the enlargement of the posterosuperior tuberosity of the calcaneus, which can cause debilitating posterior heel pain and swelling. Calcaneoplasty is indicated for the treatment of Haglund's deformity following a failure of conservative treatment. Endoscopic calcaneoplasty confers a few advantages over open surgery and has been growing in popularity as the preferred technique. This Technical Note presents an endoscopic calcaneoplasty technique with bone debridement followed by treatment with a Topaz radiofrequency device, with the patient in a supine position...
April 2024: Arthroscopy Techniques
#5
JOURNAL ARTICLE
Janduir E Silva, Joemil O Deus Junior, Guilherme Q Calixto, Dulce M A Melo, Marcus A F Melo, Vital C B Júnior, Bruna M E Chagas, Everaldo P Medeiros, Renata M Braga
The present work aimed to study different parts of colored cotton waste through energetic characterization and analytical flash pyrolysis. Stalks and bolls of BRS cotton cultivars from Sementes do Brasil (Green, Ruby, Topaz and Jade) were studied, using white cotton (BRS 286) as a comparison. The energetic potential of biomass was evaluated by bulk density, High Heating Value (HHV), proximate and ultimate analysis, compositional and thermogravimetric analysis (TGA). Pyrolysis was performed in a micro-pyrolyzer and the products were identified by gas chromatography and mass spectroscopy (Py-GC/MS)...
April 23, 2024: Scientific Reports
#6
JOURNAL ARTICLE
Marie Abitbol, Alice Couronné, Caroline Dufaure de Citres, Vincent Gache
During the last 60 years many inherited traits in domestic outbred cats were selected and retained giving birth to new breeds characterised by singular coat or morphological phenotypes. Among them, minimal white spotting associated with blue eyes was selected by feline breeders to create the Altai, Topaz, and Celestial breeds. Various established breeds also introduced this trait in their lineages. The trait, that was confirmed as autosomal dominant by breeding data, was first described in domestic cats from Kazakhstan and Russia, in British shorthair and British longhair from Russia, and in Maine Coon cats from the Netherlands, suggesting different founding effects...
April 22, 2024: Animal Genetics
#7
REVIEW
Changhoon Yoo, Jaewon Hyung, Stephen L Chan
BACKGROUND: The incidence of intrahepatic cholangiocarcinoma (IHCCA) is rising around the world. The disease is becoming a major global health issue. Conventionally, most patients with cholangiocarcinoma present with advanced disease and systemic therapy is the mainstay of treatment. This review discusses recent advances in systemic treatments for patients with IHCCA. SUMMARY: The addition of durvalumab to a gemcitabine plus cisplatin regimen has significantly improved overall survival in the phase 3 TOPAZ-1 trial and is currently recommended as a standard first-line treatment...
April 2024: Liver Cancer
#8
REVIEW
Mollie Hobensack, Hanna von Gerich, Pankaj Vyas, Jennifer Withall, Laura-Maria Peltonen, Lorraine J Block, Shauna Davies, Ryan Chan, Liesbet Van Bulck, Hwayoung Cho, Robert Paquin, James Mitchell, Maxim Topaz, Jiyoun Song
BACKGROUND: The application of large language models across commercial and consumer contexts has grown exponentially in recent years. However, a gap exists in the literature on how large language models can support nursing practice, education, and research. This study aimed to synthesize the existing literature on current and potential uses of large language models across the nursing profession. METHODS: A rapid review of the literature, guided by Cochrane rapid review methodology and PRISMA reporting standards, was conducted...
March 13, 2024: International Journal of Nursing Studies
#9
JOURNAL ARTICLE
Miriam Ryvicker, Yolanda Barrón, Jiyoun Song, Maryam Zolnoori, Shivani Shah, Julia G Burgdorf, James M Noble, Maxim Topaz
This study aimed to: (1) validate a natural language processing (NLP) system developed for the home health care setting to identify signs and symptoms of Alzheimer's disease and related dementias (ADRD) documented in clinicians' free-text notes; (2) determine whether signs and symptoms detected via NLP help to identify patients at risk of a new ADRD diagnosis within four years after admission. This study applied NLP to a longitudinal dataset including medical record and Medicare claims data for 56,652 home health care patients and Cox proportional hazard models to the subset of 24,874 patients admitted without an ADRD diagnosis...
March 31, 2024: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
#10
REVIEW
Helen Catherine Wilbur, Nilofer S Azad
Biliary tract cancers (BTCs), consisting of intrahepatic and extrahepatic cholangiocarcinoma and gallbladder cancer, are an aggressive, heterogeneous malignancy. They are most often diagnosed in the locally advanced or metastatic setting, at which point treatment consists of systemic therapy or best supportive care. Our understanding of the tumor microenvironment and the molecular classification has led to the identification of targetable mutations, such as isocitrate dehydrogenase 1 and fibroblast growth factor receptor 2...
2024: Therapeutic Advances in Medical Oncology
#11
JOURNAL ARTICLE
Alexander Olkus, Aurelie Tomczak, Anne Katrin Berger, Conrad Rauber, Philip Puchas, Cyrill Wehling, Thomas Longerich, Arianeb Mehrabi, De-Hua Chang, Jakob Liermann, Sophia Schäfer, Jan Pfeiffenberger, Dirk Jäger, Patrick Michl, Christoph Springfeld, Michael T Dill
BACKGROUND: The combination of gemcitabine and cisplatin (gem/cis) with the anti-PD-L1-antibody durvalumab was recently approved as first line therapy for biliary tract cancer (BTC) based on the results of the TOPAZ-1 trial. OBJECTIVE: We aim to analyse the feasibility and efficacy of the triple combination therapy in patients with BTC in a real-world setting and in correspondence with the genetic alterations of the cancer. METHODS: In this single-centre retrospective analysis, all patients with BTC and treated with durvalumab plus gem/cis from April 2022 to September 2023 were included...
March 2024: Targeted Oncology
#12
EDITORIAL
Khaldoun Almhanna
No abstract text is available yet for this article.
January 31, 2024: Translational Cancer Research
#13
Eugene Kwong Fei Leong, Nigel Chun Hian Tan, Ning Qi Pang, Alfred Wei Chieh Kow
INTRODUCTION: Biliary tract cancers (BTC) are often diagnosed at an advanced stage where prognosis is poor and curative-intent surgery is infeasible. First-line cisplatin-gemcitabine chemotherapy for advanced gallbladder cancer has remained unchanged over more than a decade, but recent developments in immunotherapy such as durvalumab have highlighted promise as a combination treatment regime with current standard chemotherapy. METHODS: In this case description, we present a case of locally-advanced gallbladder adenocarcinoma involving the biliary confluence that was initially planned for an extended right hepatectomy after portal vein embolization...
2024: Frontiers in Immunology
#14
JOURNAL ARTICLE
Eunjoo Jeon, Laura-Maria Peltonen, Lorraine J Block, Charlene Ronquillo, Jude L Tayaben, Raji Nibber, Lisiane Pruinelli, Erika Lozada Perezmitre, Janine Sommer, Maxim Topaz, Gabrielle Jacklin Eler, Henrique Yoshikazu Shishido, Shanti Wardaningsih, Sutantri Sutantri, Samira Ali, Dari Alhuwail, Alaa Abd-Alrazaq, Laila Akhu-Zaheya, Ying-Li Lee, Shao-Hui Shu, Jisan Lee
OBJECTIVES: With the sudden global shift to online learning modalities, this study aimed to understand the unique challenges and experiences of emergency remote teaching (ERT) in nursing education. METHODS: We conducted a comprehensive online international cross-sectional survey to capture the current state and firsthand experiences of ERT in the nursing discipline. Our analytical methods included a combination of traditional statistical analysis, advanced natural language processing techniques, latent Dirichlet allocation using Python, and a thorough qualitative assessment of feedback from open-ended questions...
January 2024: Healthcare Informatics Research
#15
JOURNAL ARTICLE
Margherita Rimini, Eleonora Loi, Mario Domenico Rizzato, Tiziana Pressiani, Caterina Vivaldi, Eleonora Gusmaroli, Lorenzo Antonuzzo, Erika Martinelli, Ingrid Garajova, Guido Giordano, Jessica Lucchetti, Marta Schirripa, Noemi Cornara, Federico Rossari, Francesco Vitiello, Elisabeth Amadeo, Mara Persano, Vittoria Matilde Piva, Rita Balsano, Francesca Salani, Chiara Pircher, Stefano Cascinu, Monica Niger, Lorenzo Fornaro, Lorenza Rimassa, Sara Lonardi, Mario Scartozzi, Patrizia Zavattari, Andrea Casadei-Gardini
BACKGROUND: The results reported in the TOPAZ-1 phase III trial led to the approval of the combination of cisplatin and gemcitabine with durvalumab as the new first-line standard of care for patients with locally advanced or metastatic cholangiocarcinoma. OBJECTIVE: We performed a clustering analysis to classify patients into different groups based on their mutation profile, correlating the results of the analysis with clinical outcomes. METHODS: We selected 51 patients with cholangiocarcinoma who were treated with the combination of chemotherapy and durvalumab and who were screened using the next-generation sequencing-based FoundationOne gene panel...
March 2024: Targeted Oncology
#16
JOURNAL ARTICLE
Aviv Y Landau, Chinmayi Venkatram, Jiyoun Song, Maxim Topaz, Robert Klitzman, Jingjing Shang, Patricia Stone, Margaret McDonald, Bevin Cohen
Advance care planning is important and timely for patients receiving home health services; however, opportunities to facilitate awareness and engagement in this setting are often missed. This qualitative descriptive study elicited perspectives of home health nurses and social workers regarding barriers and facilitators to creating advance care plans in home health settings, with particular attention to patients with few familial or social contacts who can serve as surrogate decision-makers. We interviewed 15 clinicians employed in a large New York City-based home care agency in 2021-2022...
February 10, 2024: Journal of Hospice and Palliative Nursing: JHPN
#17
RANDOMIZED CONTROLLED TRIAL
Thomas O Crawford, Basil T Darras, John W Day, Sally Dunaway Young, Tina Duong, Leslie L Nelson, Doreen Barrett, Guochen Song, Sanela Bilic, Shaun Cote, Mara Sadanowicz, Ryan Iarrobino, Tiina J Xu, Janet O'Neil, José Rossello, Amy Place, Nathalie Kertesz, George Nomikos, Yung Chyung
BACKGROUND AND OBJECTIVES: Currently approved therapies for spinal muscular atrophy (SMA) reverse the degenerative course, leading to better functional outcome, but they do not address the impairment arising from preexisting neurodegeneration. Apitegromab, an investigational, fully human monoclonal antibody, inhibits activation of myostatin (a negative regulator of skeletal muscle growth), thereby preserving muscle mass. The phase 2 TOPAZ trial assessed the safety and efficacy of apitegromab in individuals with later-onset type 2 and type 3 SMA...
March 12, 2024: Neurology
#18
REVIEW
Emilie A K Warren, Shishir K Maithel
Cholangiocarcinoma (CCA) represents a group of epithelial cell tumors classified based on their anatomic location along the biliary tree. This rare malignancy is often diagnosed at an advanced stage and deemed unresectable. Even for those patients who are surgical candidates, recurrence rates are high and survival rates low. The mainstay of therapy for advanced CCA remains cisplatin plus gemcitabine, with a median overall survival (mOS) under 12 months, although the TOPAZ-1 trial showed a survival benefit with the addition of programmed cell death ligand 1 (PD-L1) blockade...
February 1, 2024: Hepatobiliary Surgery and Nutrition
#19
JOURNAL ARTICLE
S A Sinclair, M I Pech-Canul, M C Acosta-Enríquez, R Meléndrez Amavizca, Alejandro Sala Crist, J Marcazzó
Topaz (Al2 F1·44 (OH)0·56 SiO4 )/corundum (Al2 O3 ) composites were prepared by a facile and novel reversible process from the sintering of synthetic topaz and AlF3 powders, with corundum formed in situ into the topaz matrix. The corundum formation reaction occurs in the temperature range 875-975 °C, from 40 min sintering time, obtaining the topaz- Al2 F1·44 (OH)0·56 SiO4 /corundum- Al2 O3 composites. Although sintering temperature and time increment lead to higher corundum formation in the topaz matrix (78...
February 15, 2024: Heliyon
#20
JOURNAL ARTICLE
Maxim Topaz, Laura-Maria Peltonen, Martin Michalowski, Gregor Stiglic, Charlene Ronquillo, Lisiane Pruinelli, Jiyoun Song, Siobhan O'Connor, Shoko Miyagawa, Hiroki Fukahori
This article examines the potential of generative artificial intelligence (AI), such as ChatGPT (Chat Generative Pre-trained Transformer), in nursing education and the associated challenges and recommendations for their use. Generative AI offers potential benefits such as aiding students with assignments, providing realistic patient scenarios for practice, and enabling personalized, interactive learning experiences. However, integrating generative AI in nursing education also presents challenges, including academic integrity issues, the potential for plagiarism and copyright infringements, ethical implications, and the risk of producing misinformation...
February 5, 2024: Journal of Nursing Education
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