Guilherme Lopes-Gonçalves, Juliana Martins Costa-Pessoa, Ruan Pimenta, Ana Flavia Tostes, Eloisa Martins da Silva, Felipe Lourenço Ledesma, Denise Maria Avancini Costa Malheiros, Roberto Zatz, Karina Thieme, Niels Olsen Saraiva Câmara, Maria Oliveira-Souza
Focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome, which is characterized by podocyte injury. Given that the pathophysiology of nondiabetic glomerulosclerosis is poorly understood and targeted therapies to prevent glomerular disease are lacking, we decided to investigate the tight junction protein claudin-1 and the histone deacetylase sirtuin-1 (SIRT1), which are known to be involved in podocyte injury. For this purpose, we first examined SIRT1, claudin-1 and podocin expression in kidney biopsies from patients diagnosed with nondiabetic FSGS and found that upregulation of glomerular claudin-1 accompanies a significant reduction in glomerular SIRT1 and podocin levels...
December 19, 2023: Scientific Reports