Adnan Mahly, Krishnanand Padmanabhan, Arad Soffer, Jonathan Cohen, Jana Omar, Ronit Sagi-Eisenberg, Chen Luxenburg
BACKGROUND: The establishment of tissue architecture requires coordination between distinct processes including basement membrane assembly, cell adhesion, and polarity; however, the underlying mechanisms remain poorly understood. The actin cytoskeleton is ideally situated to orchestrate tissue morphogenesis due to its roles in mechanical, structural, and regulatory processes. However, the function of many pivotal actin-binding proteins in mammalian development is poorly understood. RESULTS: Here, we identify a crucial role for anillin (ANLN), an actin-binding protein, in orchestrating epidermal morphogenesis...
June 16, 2022: BMC Biology