Edward Zoratti, Robert Wood, Anna Pomés, Ricardo Da Silva Antunes, Matthew C Altman, Basilin Benson, Lisa M Wheatley, Kate Cho, Agustin Calatroni, Frederic F Little, J Pongracic, Melanie Makhija, Gurjit K Khurana Hershey, Michael G Sherenian, Katherine Rivera-Spoljaric, Jeffrey R Stokes, Michelle A Gill, Rebecca S Gruchalla, Jeffrey Chambliss, Andrew H Liu, Meyer Kattan, Paula J Busse, Leonard B Bacharier, William Sheehan, Haejin Kim, Jill Glesner, Peter J Gergen, Alkis Togias, Jessica L Baucom, Cynthia M Visness, Alessandro Sette, William W Busse, Daniel J Jackson
BACKGROUND: Cockroach allergy contributes to morbidity among urban children with asthma. Few trials address the effect of subcutaneous immunotherapy (SCIT) with cockroach allergen among these at-risk children. OBJECTIVE: To determine if nasal allergen challenge (NAC) responses to cockroach allergen would improve following one year of SCIT. METHODS: Urban children with asthma, that were cockroach-sensitized and reactive on NAC, participated in a yearlong randomized double-blind placebo-controlled SCIT trial using German cockroach extract...
May 6, 2024: Journal of Allergy and Clinical Immunology