Juhina Das, Saurav Bera, Nilanjan Ganguly, Ipsita Guha, Tithi Ghosh Halder, Avishek Bhuniya, Partha Nandi, Mohona Chakravarti, Sukanya Dhar, Anirban Sarkar, Tapasi Das, Saptak Banerjee, Sandip Ghose, Anamika Bose, Rathindranath Baral
INTRODUCTION: Murine tumor growth restriction by neem leaf glycoprotein (NLGP) was established in various transplanted models of murine sarcoma, melanoma and carcinoma. However, the role of NLGP in the sequential carcinogenic steps has not been explored. Thus, tongue carcinogenesis in Swiss mice was induced by 4-nitroquinoline-1-oxide (4NQO), which has close resemblance to human carcinogenesis process. Interventional role of NLGP in initiation-promotion protocol established during 4NQO mediated tongue carcinogenesis in relation to systemic immune alteration and epithelial-mesenchymal transition (EMT) is investigated...
2024: Frontiers in Immunology