Samantha W J He, Franziska Voß, Mioara A Nicolaie, Jolanda Brummelman, Martijn D B van de Garde, Elske Bijvank, Martien Poelen, Alienke J Wijmenga-Monsuur, Anne L Wyllie, Krzysztof Trzciński, Josine Van Beek, Nynke Y Rots, Gerco den Hartog, Sven Hammerschmidt, Cécile A C M van Els
Streptococcus pneumoniae is a leading cause of morbidity and mortality in children and older adults. Yet knowledge on the development of pneumococcal protein-specific antibody responses throughout life is limited. To investigate this, we measured serum IgG levels to 55 pneumococcal proteins in 11-month old infants (n=73), 24-month old children (n=101), parents (n=99), adults without children <6 years of age (n= 99) and older adults aged >60 years (n=100). Our findings revealed low IgG levels in infancy, with distinct development patterns peaking in adults...
April 29, 2024: Journal of Infectious Diseases