Cihan Ay, Mariasanta Napolitano, Abel Hassoun, Radovan Tomic, Cedric Martin, Wilfried Seifert, Karen Pinachyan, Johannes Oldenburg
INTRODUCTION: Consensus over the definition of recombinant factor VIII (rFVIII) product classification in haemophilia A is lacking. rFVIII products are often classified as standard half-life (SHL) or extended half-life (EHL); despite this, no universally accepted definition currently exists. One proposed definition includes half-life, area under the curve, and technology designed to extend half-life; however, the International Society on Thrombosis and Haemostasis defines activity over time as the most intuitive information for building treatment regimens and the World Federation of Hemophilia describes rFVIII product classification in terms of infusion frequency...
March 29, 2024: Haemophilia: the Official Journal of the World Federation of Hemophilia