Celine Gys, Olivier Mortelé, Babette Van Rafelghem, Eleanor Berry, Alexander L N van Nuijs, Willy Lambert, Werner Jacobs, Sofie Schouwers, Anissa Meskal, Ellen Van Hemeldonck, Luc Heytens, Hugo Neels, Adrian Covaci
Toxicological data on overdose with HIV-inhibitors is scarce. We present a case report of two independent suicide attempts by self-administered overdose with the same antiretroviral medicine Genvoya® (emtricitabine/elvitegravir/tenofovir alafenamide/cobicistat). Both patients were admitted to the hospital and presented with a loss of consciousness, lactic acidosis, elevated hepatic transaminase levels and hemodynamic instability. While one patient survived with advanced supportive measures, the other passed away...
August 3, 2022: Journal of Analytical Toxicology