Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Yan Li, Yunqing Wang, Rongchao Mei, Bingqian Lv, Xizhen Zhao, Liyan Bi, Hui Xu, Lingxin Chen
In vivo drug monitoring is crucial for evaluating the effectiveness and safety of drug treatment. Blood sampling and analysis is the current gold standard but needs professional skills and cannot meet the requirements of point-of-care testing. Dermal interstitial fluid (ISF) showed great potential to replace blood for in vivo drug monitoring; however, the detection was challenging, and the drug distribution behavior in ISF was still unclear until now. In this study, we proposed surface-enhanced Raman spectroscopy (SERS) microneedles (MNs) for the painless and real-time analysis of drugs in ISF after intravenous injection...
May 2, 2024: ACS Sensors
#2
JOURNAL ARTICLE
Antti Turunen, Krista Kuuliala, Antti Kuuliala, Pauli Puolakkainen, Leena Kylänpää, Johanna Hästbacka, Outi Lindström
OBJECTIVES: To study fluid balance and endothelial glycocalyx degradation, reflected by syndedan-1 and heparan sulfate (HS) levels, in early stages of acute pancreatitis (AP). METHODS: This study comprised of 210 AP patients (104 mild, 53 moderately severe, 17 severe). Blood was sampled within 72 h from the onset of symptoms, and plasma syndecan-1 and HS levels were determined using ELISA. Fluid balance up to sampling and up to 4 days was determined retrospectively from medical records...
May 1, 2024: Pancreas
#3
JOURNAL ARTICLE
Alexander J Beagle, Priya A Prasad, Colin C Hubbard, Sven Walderich, Sandra Oreper, Yumiko Abe-Jones, Margaret C Fang, Kirsten N Kangelaris
OBJECTIVES: To evaluate the relationship between early IV fluid volume and hospital outcomes, including death in-hospital or discharge to hospice, in septic patients with and without heart failure (HF). DESIGN: A retrospective cohort study using logistic regression with restricted cubic splines to assess for nonlinear relationships between fluid volume and outcomes, stratified by HF status and adjusted for propensity to receive a given fluid volume in the first 6 hours...
May 2024: Critical care explorations
#4
JOURNAL ARTICLE
Hatice Eryigit Unaldi
INTRODUCTION: Although primary spontaneous pneumothorax is a common disease in young adults, each thoracic surgery department performs different procedures for its management. AIM: The optimal time of postoperative mobilization is not yet standardized in lung surgery. MATERIAL AND METHODS: This study included male patients with a primary spontaneous pneumothorax who underwent wedge resection of the upper lobe of the lungs via uniportal video-assisted thoracoscopic surgery...
March 2024: Polish Journal of Cardio-Thoracic Surgery
#5
JOURNAL ARTICLE
Pankti P Acharya, Crystal Joseph
BACKGROUND: Zoledronate, a bisphosphonate, is a potent first-line treatment for osteoporosis. It is also a preferred treatment for hypercalcemia especially when unresponsive to intravenous fluids. Bisphosphonates can cause acute phase reactions that mimic opioid withdrawal symptoms, which can confound provider decision-making. Our case highlights cognitive bias involving a patient with opioid use disorder who received zoledronate for hypercalcemia secondary to immobilization and significant bone infection...
May 1, 2024: Addiction Science & Clinical Practice
#6
JOURNAL ARTICLE
Steven R Insler, Brett Wakefield, Andrea Debs, Kelly Brake, Ikenna Nwosu, Diana Isaacs, James Bena, M Cecilia Lansang
UNLABELLED: Cardiac surgery is associated with hyperglycemia, which in turn is associated with adverse post-surgical outcomes such as wound infections, acute renal failure, and mortality. This pilot study seeks to determine if Dexcom G6Pro continuous glucose monitor (Dexcom G6Pro CGM) is accurate during the postoperative cardiac surgery period when fluid shifts, systemic inflammatory response syndrome (SIRS), and vasoactive medications are frequently encountered, compared to standard glucose monitoring techniques...
April 29, 2024: Endocrine Practice
#7
JOURNAL ARTICLE
Chenxiao Hao, Rui Hao, Huiying Zhao, Yong Zhang, Ming Sheng, Youzhong An
PURPOSE: The recognition of sepsis as a heterogeneous syndrome necessitates identifying distinct subphenotypes to select targeted treatment. METHODS: Patients with sepsis from the MIMIC-IV database (2008-2019) were randomly divided into a development cohort (80%) and an internal validation cohort (20%). Patients with sepsis from the ICU database of Peking University People's Hospital (2008-2022) were included in the external validation cohort. Time-series k-means clustering analysis and dynamic time warping was performed to develop and validate sepsis subphenotypes by analyzing the trends of 21 vital signs and laboratory indicators within 24 h after sepsis onset...
April 15, 2024: Heliyon
#8
Sunil Krishna, Mary Augustian
Pseudohypoaldosteronism type 1 is a rare genetic disorder characterized by salt wasting and resistance to mineralocorticoids due to mutations in the NR3C2 gene which codes for the aldosterone receptor proteins in the kidneys. This case study involves an infant who presented with poor growth and significant hyponatremia. There was improvement in growth and correction of hyponatremia with sodium supplementation, later found to carry a new genetic variant causing autosomal dominant pseudohypoaldosteronism type 1...
April 2024: Curēus
#9
JOURNAL ARTICLE
Ali Elnagar, Mpho Kgomo, Modise Mokone, Badreldin Yousif
SummaryCannabis use is legalised in many countries. We present a patient in their 40s who complained of recurrent abdominal pain and associated nausea and vomiting. The patient was previously seen in various hospitals, treated symptomatically, and discharged with a diagnosis of non-specific abdominal pain. The patient had a chronic history of smoking cannabis and nicotine and drinking alcohol. Abdominal examination revealed no masses, and abdominal X-ray was normal. Blood tests and gastroduodenoscopy revealed no obvious aetiology...
April 30, 2024: BMJ Case Reports
#10
JOURNAL ARTICLE
Jacobo Romano Noriega, Elizabeth J Thomovsky
OBJECTIVE: To provide a video tutorial describing intraperitoneal (IP) and intracoelomic (IC) therapeutics (IP/IC fluids, euthanasia, direct peritoneal resuscitation). ANIMALS: Dogs, cats, and exotic pets. METHODS: Peritoneal and coelomic centesis allows for delivery of fluids or to perform euthanasia. The peritoneal and coelomic membranes contain a vast network of capillaries and lymphatics that allow absorption of fluids and blood products...
April 30, 2024: Journal of the American Veterinary Medical Association
#11
JOURNAL ARTICLE
Roland Immler, Katrin Nussbaumer, Axel Doerner, Omar El Bounkari, Silke Huber, Janine Abisch, Matteo Napoli, Sarah Schmidt, Andreas Margraf, Monika Pruenster, Ina Rohwedder, Baerbel Lange-Sperandio, Marcus A Mall, Renske de Jong, Caspar Ohnmacht, Juergen Bernhagen, David Voehringer, Jamey D Marth, David Frommhold, Markus Sperandio
Eosinophil recruitment is a pathological hallmark of many allergic and helminthic diseases. Here, we investigated chemokine receptor CCR3-induced eosinophil recruitment in sialyltransferase St3gal4-/- mice. We found a marked decrease in eosinophil extravasation into CCL11-stimulated cremaster muscles and into the inflamed peritoneal cavity of St3gal4-/- mice. Ex vivo flow chamber assays uncovered reduced adhesion of St3gal4 -/- compared to wild type eosinophils. Using flow cytometry, we show reduced binding of CCL11 to St3gal4-/- eosinophils...
May 7, 2024: Proceedings of the National Academy of Sciences of the United States of America
#12
JOURNAL ARTICLE
Sandra Lundgren, Kristoffer Dreimanis, Karolina Engdahl, Ulrika Windahl, Cecilia Tegner
OBJECTIVES: The aims of this study were to describe the clinical picture and progression in cats with alpha-chloralose (AC) intoxication and to determine if treatment with intravenous (IV) lipid emulsion (ILE) influenced either the serum concentration of AC or the clinical signs. METHODS: Cats with suspected AC poisoning admitted to a university small animal hospital were included. The cats were randomised into two groups: one receiving 20% ILE at a dose of 300 mg/kg as a 2 min bolus, followed by a 1500 mg/kg continuous rate infusion over 30 mins (IL+ group) and the other receiving IV fluid therapy with Ringer's acetate (IL- group)...
April 2024: Journal of Feline Medicine and Surgery
#13
JOURNAL ARTICLE
Bastien A Valencia-Sanchez, Michael Levy, Vijay A Patel
BACKGROUND AND IMPORTANCE: Basal encephaloceles are the result of a concomitant cranial and dural defect that allows for inferior displacement of cerebral tissue, meninges, and cerebrospinal fluid into the paranasal sinuses and outside the cranial vault. This work illustrates a step-by-step surgical approach of a successful single-stage, endoscopic repair of a congenital basal encephalocele in a 10-year-old child, using a free mucosal middle turbinate graft that provided effective results without utilization of traditional open reconstructive techniques or vascularized flaps...
April 30, 2024: Operative Neurosurgery (Hagerstown, Md.)
#14
JOURNAL ARTICLE
Lina Gong, Dongzhen Yu, Yaqin Wu, Zhengnong Chen, Shankai Yin
Objective: To assess the effectiveness of microvascular decompression（MVD） in treating inpatients suffering from primary hemifacial spasm（HFS）. Methods: A total of 21 inpatients with HFS underwent MVD. The clinical effect was follow up evaluated according to the clinical symptoms until post operative 6 months. Results: The effective rate of MVD for 1 day, 14 days, 1 month, 3 months and 6 months post-operation was 95.2%, 100%, 100%, 100% and 100%, respectively.one patient had transient tinnitus and the symptom disappeared within 6 days postoperatively...
May 2024: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
#15
JOURNAL ARTICLE
Javier Ripollés-Melchor, Laura Carrasco-Sánchez, José L Tomé-Roca, César Aldecoa, Andres Zorrilla-Vaca, Juan V Lorente-Olazábal, María J Colomina, Ana Pérez, Juan I Jiménez-López, Rosalía Navarro-Pérez, Alfredo Abad-Gurumeta, Manuel I Monge-García
BACKGROUND: Acute kidney injury (AKI) is a significant postoperative complication associated with increased mortality and hospital costs. Hemodynamic strategies, such as goal-directed therapy, might reduce AKI risk. Predicting and proactively managing intraoperative hypotension may be helpful. This trial aims to investigate if a preemptive hemodynamic strategy guided by the hypotension prediction index (HPI) can decrease the incidence of moderate-to-severe AKI within 30 days following major elective abdominal surgery...
April 29, 2024: Trials
#16
JOURNAL ARTICLE
Takao Kashiwagi, Yuki Kashiwagi, Tomohide Suzuki, Manami Shingu, Sayaka Kashiwagi, Tamaki Hirata, Junko Hori, Keikichi Miyata, Miho Takechi, Minoru Kishi, Takamasa Ohnishi, Yoshio Katayama, Masahide Iwai, Toshimitsu Matsui
We report the case of a 48-year-old man who presented with fatigue and weight loss. A local physician observed elevated alkaline phosphatase levels, anemia, thrombocytopenia, and renal dysfunction. Fever also appeared, and the patient was admitted to our hospital. Computed tomography revealed hepatosplenomegaly, pleural and ascitic fluid, and left axillary lymphadenopathy. Bone marrow biopsy indicated hyperplasia with increased megakaryocytes and reticulin fibrosis. Axillary lymph node biopsy showed Castleman's disease-like features...
2024: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
#17
JOURNAL ARTICLE
Olivia Wagemann, Haiyan Liu, Guoqiao Wang, Xinyu Shi, Tobias Bittner, Marzia A Scelsi, Martin R Farlow, David B Clifford, Charlene Supnet-Bell, Anna M Santacruz, Andrew J Aschenbrenner, Jason J Hassenstab, Tammie L S Benzinger, Brian A Gordon, Kelley A Coalier, Carlos Cruchaga, Laura Ibanez, Richard J Perrin, Chengjie Xiong, Yan Li, John C Morris, James J Lah, Sarah B Berman, Erik D Roberson, Christopher H van Dyck, Douglas Galasko, Serge Gauthier, Ging-Yuek R Hsiung, William S Brooks, Jérémie Pariente, Catherine J Mummery, Gregory S Day, John M Ringman, Patricio Chrem Mendez, Peter St George-Hyslop, Nick C Fox, Kazushi Suzuki, Hamid R Okhravi, Jasmeer Chhatwal, Johannes Levin, Mathias Jucker, John R Sims, Karen C Holdridge, Nicholas K Proctor, Roy Yaari, Scott W Andersen, Michele Mancini, Jorge Llibre-Guerra, Randall J Bateman, Eric McDade
IMPORTANCE: Effects of antiamyloid agents, targeting either fibrillar or soluble monomeric amyloid peptides, on downstream biomarkers in cerebrospinal fluid (CSF) and plasma are largely unknown in dominantly inherited Alzheimer disease (DIAD). OBJECTIVE: To investigate longitudinal biomarker changes of synaptic dysfunction, neuroinflammation, and neurodegeneration in individuals with DIAD who are receiving antiamyloid treatment. DESIGN, SETTING, AND PARTICIPANTS: From 2012 to 2019, the Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU-001) study, a double-blind, placebo-controlled, randomized clinical trial, investigated gantenerumab and solanezumab in DIAD...
April 29, 2024: JAMA Neurology
#18
JOURNAL ARTICLE
I Tsouknidas, S Perez, E Kunkel, C Tiko-Okoye, M E Buckley, J Y Gefen
PURPOSE: Post-operative urinary retention (POUR) is a known complication of hernia surgery. Minimally invasive inguinal hernia repair (IHR) is typically done under general anesthesia with neuromuscular blockade (NMB), which is commonly reversed with an anticholinesterase inhibitor paired with an anticholinergic agent. Sugammadex is a unique NMB reversal agent that does not have to be paired with an anticholinergic. We sought to explore the role of sugammadex in reducing the rate of POUR following these procedures...
April 29, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
#19
Erin F Pinnell, Jiwoong Her, Daniel Gordon, Hannah M Kinsella, Catherine E Langston, Ramiro E Toribio
An adult American Quarter Horse mare presented for pigmenturia and lethargy of 12 hours' duration and was diagnosed with silver maple leaf toxicity. The mare had intravascular hemolysis and azotemia. The mare was treated with a transfusion of whole blood, fluids administered IV, antibiotics, oxygen insufflation, and supportive care. The azotemia persisted despite conventional medical management and hemodialysis was elected. After 2 intermittent hemodialysis treatments over 3 days, the azotemia almost resolved, clinical signs improved, and the mare was discharged...
April 29, 2024: Journal of Veterinary Internal Medicine
#20
JOURNAL ARTICLE
Fatemeh Ghorbani, Ghader Jalilzadeh-Amin, Bahram Dalir-Naghade, Siamak Asri Rezaei
BACKGROUND: Bronchoalveolar lavage (BAL) is a method for collecting the cellular and fluid components of the airway surface in the lungs. The assessment of differential cell profiles is potentially valuable in the diagnosis of pulmonary diseases, but there is no information about the normal BAL profiles in the Gezel breed. AIM: This study aimed to characterize the normal cryptologic findings of BAL with Gezel sheep. METHODS: Twenty healthy sheep (15 females: 5 males, bodyweight: 55-65 kg) were sedated with xylazine (0...
March 2024: Open Veterinary Journal
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
