Ana-Citlali Gradilla, Esperanza González, Irene Seijo, German Andrés, Marcus Bischoff, Laura González-Mendez, Vanessa Sánchez, Ainhoa Callejo, Carmen Ibáñez, Milagros Guerra, João Ramalho Ortigão-Farias, James D Sutherland, Monika González, Rosa Barrio, Juan M Falcón-Pérez, Isabel Guerrero
The Hedgehog signalling pathway is crucial for development, adult stem cell maintenance, cell migration and axon guidance in a wide range of organisms. During development, the Hh morphogen directs tissue patterning according to a concentration gradient. Lipid modifications on Hh are needed to achieve graded distribution, leading to debate about how Hh is transported to target cells despite being membrane-tethered. Cytonemes in the region of Hh signalling have been shown to be essential for gradient formation, but the carrier of the morphogen is yet to be defined...
2014: Nature Communications