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JOURNAL ARTICLE
Farhan Khan M Pathan, Joseley Sunderraj Pandian, Anis I Shaikh, Mohammad Ahsan, Shibili Nuhmani, Amir Iqbal, Ahmad H Alghadir
PURPOSE: The present study aims to investigate the combined effect of slow breathing exercise (SBE) and progressive muscle relaxation (PMR) technique on blood pressure (BP), heart rate (HR), respiratory rate (RR), and anxiety in patients diagnosed with essential hypertension. TRIAL DESIGN: This study was based on a 4-arm parallel-group, randomized control design. METHODS: Sixty-four participants diagnosed with essential hypertension were randomly allocated into SBE, PMR, SBE-PMR, and Control groups, with 16 subjects each...
November 24, 2023: Medicine (Baltimore)
#22
JOURNAL ARTICLE
Yingxiao Li, Kai-Chun Cheng, I-Min Liu, Juei-Tang Cheng
Andrographolide (ADG) is contained in bitter plants, and its effects are widely thought to be associated with taste receptors. The current study used animal studies and cell lines to investigate the role of ADG in diabetic models. The Takeda G-protein-coupled receptor (TGR5) was directly influenced by ADG, and this boosted GLP-1 synthesis in CHO-K1 cells transfected with the TGR5 gene. However, this was not seen in TGR5-mutant cells. The human intestinal L-cell line NCI-H716 showed an increase in GLP-1 production in response to ADG...
October 5, 2023: Pharmaceuticals
#23
JOURNAL ARTICLE
Ali A Alshamrani, Mohammed A Al-Hamamah, Norah A Albekairi, Mohamed S M Attia, Sheikh F Ahmad, Mohammed A Assiri, Mushtaq A Ansari, Ahmed Nadeem, Saleh A Bakheet, Wael A Alanazi, Sabry M Attia
Diabetes mellitus is a metabolic disease that can cause systemic problems, including testicular dysfunction. Several diabetes medications have demonstrated potential adverse effects on the male reproductive system; however, the effects of saxagliptin and dapagliflozin have not been sufficiently examined. This investigation studied the impacts of saxagliptin and dapagliflozin treatments on the gonads in a male mouse model of diabetes. Testicular disturbances were assessed by sperm DNA damage, diakinesis-metaphase I chromosome examination, and spermiogram analysis...
September 29, 2023: Biomedicines
#24
JOURNAL ARTICLE
Phyo T Htoo, Robert J Glynn, Shirley Wang, Julie M Paik, Sebastian Schneeweiss, Alexander M Walker, Elisabetta Patorno
PURPOSE: For observational cohort studies that employ matching by propensity scores (PS), preliminary stratification by consequential predictors of outcome better emulates stratified randomization and potentially reduces variance and bias through relaxed dependence on modeling assumptions. We assessed the impact of pre-stratification in two real-life examples. For both, prior evidence from placebo-controlled randomized clinical trials (RCTs) suggested small or no risk reduction, but observational analysis suggested protection, presumably the result of confounding bias...
October 25, 2023: Pharmacoepidemiology and Drug Safety
#25
JOURNAL ARTICLE
Hou-Ren Tsai, Yu-Jie Lin, Jih-I Yeh, Yu-Chi Huang, Peter Pin-Sung Liu, Carol Chiung-Hui Peng, Jin-Yi Hsu, Yuan-Chieh Lee, Ching-Hui Loh, Shu-Man Lin, Huei-Kai Huang
AIMS: Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) have off-target effects on haemoconcentration and anti-inflammation. The impact of SGLT-2i on the risk of venous thromboembolism (VTE) in patients with diabetes mellitus (DM) remains unclear. This study aimed to evaluate the risk of newly diagnosed VTE in patients with DM using SGLT-2i in comparison to dipeptidyl peptidase-4 inhibitors (DPP-4i) or glucagon-like peptide-1 receptor agonists (GLP-1RA). MATERIALS AND METHODS: In this nationwide retrospective cohort study, we used data from Taiwan's National Health Insurance Research Database...
October 20, 2023: Diabetes/metabolism Research and Reviews
#26
JOURNAL ARTICLE
Vincenzo M Monda, Claudio Voci, Felice Strollo, Angelina Passaro, Salvatore Greco, Marcello Monesi, Renato Bigoni, Francesca Porcellati, Daniela Piani, Ersilia Satta, Sandro Gentile
INTRODUCTION: Type 2 diabetes mellitus (T2DM) is a relevant risk factor for severe forms of COVID-19 (SARS coronavrus 2 [SARS-CoV-2] disease 2019), and calls for caution because of the high prevalence of T2DM worldwide and the high mortality rates observed in patients with T2DM who are infected with SARS-CoV-2. People with T2DM often take dipeptidyl peptidase-4 inhibitors (DPP-4is), glucagon-like peptide-1 receptor agonists (GLP-1ras), or sodium-glucose co-transporter-2 inhibitors (SGLT-2is), all of which have clear anti-inflammatory effects...
October 6, 2023: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
#27
RANDOMIZED CONTROLLED TRIAL
Arvid Sandforth, Reiner Jumpertz von Schwartzenberg, Elsa Vazquez Arreola, Robert L Hanson, Gencer Sancar, Sarah Katzenstein, Karl Lange, Hubert Preißl, Simon I Dreher, Cora Weigert, Robert Wagner, Kostantinos Kantartzis, Jürgen Machann, Fritz Schick, Rainer Lehmann, Andreas Peter, Nikoletta Katsouli, Vasilis Ntziachristos, Corinna Dannecker, Louise Fritsche, Nikolaos Perakakis, Martin Heni, Peter Paul Nawroth, Stefan Kopf, Andreas F H Pfeiffer, Stefan Kabisch, Michael Stumvoll, Peter E H Schwarz, Hans Hauner, Andreas Lechner, Jochen Seissler, Iryna Yurchenko, Andrea Icks, Michele Solimena, Hans-Ulrich Häring, Julia Szendroedi, Annette Schürmann, Martin Hrabé de Angelis, Matthias Blüher, Michael Roden, Stefan R Bornstein, Norbert Stefan, Andreas Fritsche, Andreas L Birkenfeld
BACKGROUND: Remission of type 2 diabetes can occur as a result of weight loss and is characterised by liver fat and pancreas fat reduction and recovered insulin secretion. In this analysis, we aimed to investigate the mechanisms of weight loss- induced remission in people with prediabetes. METHODS: In this prespecified post-hoc analysis, weight loss-induced resolution of prediabetes in the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS) was assessed, and the results were validated against participants from the Diabetes Prevention Program (DPP) study...
November 2023: Lancet Diabetes & Endocrinology
#28
REVIEW
Katarzyna Wnuk, Jakub Świtalski, Tomasz Tatara, Wojciech Miazga, Sylwia Jopek, Anna Augustynowicz, Urszula Religioni, Mariusz Gujski
PURPOSE OF REVIEW: Type 2 diabetes mellitus (T2DM) is a chronic disease that may lead to severe complications. The main methods of preventing or delaying the onset of T2DM include lifestyle changes. The purpose of this study is to identify and evaluate the effectiveness of workplace interventions aimed at preventing type 2 diabetes. An umbrella review was conducted in accordance with the Cochrane Collaboration guidelines. Searches were performed in Medline (via PubMed), Embase (via OVID), and Cochrane Library databases...
September 20, 2023: Current Diabetes Reports
#29
JOURNAL ARTICLE
Ke Wang, Liu Gao, Chang Liu, Xiaoxue Bao, Yawei Tian, Yukun Li
This study aimed to determine whether RANKL inhibitors in postmenopausal osteoporosis patients with combined type 2 diabetes mellitus (T2DM) could improve their glucose metabolism index. First of all, 84 patients affected with postmenopausal osteoporosis with combined T2DM attending the Department of Endocrinology at the Third Hospital of Hebei Medical University were selected and randomized into two groups of 42 patients each. One group was given Denosumab 60 mg once every six months (denosumab group, D.G...
August 31, 2023: Cellular and Molecular Biology
#30
JOURNAL ARTICLE
Chih-Ying Wu, Shubham Suresh Ghule, Chih-Chuang Liaw, David Achudhan, Shuen-Yih Fang, Po-I Liu, Chang-Lun Huang, Ching-Liang Hsieh, Chih-Hsin Tang
Lung cancer is the leading cause of cancer-related death worldwide, and the survival rate of metastatic lung cancer is exceedingly low. Helminthostatchys Zeylanica (H. Zeylanica) is a Chinese herbal medicine renowned for its anti-inflammatory, immunomodulatory, and anti-cancer activities in various cellular and animal studies. The current study evaluated the effects of H. Zeylanica derivatives on lung cancer cells. We determined that dipeptidyl peptidase-4 (DPP-4) expression levels were higher in lung cancer tissues than in normal tissues...
September 11, 2023: Biomedicine & Pharmacotherapy
#31
JOURNAL ARTICLE
I N Tyurenkov, T I Faibisovich, D A Bakulin
Diabetes mellitus (DM) is the leading cause of premature death and disability. Despite a significant number of drugs, the effectiveness of therapy aimed at normalizing the level of glycemia and preventing complications does not fully satisfy doctors and patients. Therefore, the search for new approaches for the prevention and treatment of DM and its complications continues. Significant resources are used to develop new drugs, but recently the possibility of using «old» widely available drugs with newly discovered pleiotropic properties has been substantiated...
August 30, 2023: Problemy E̊ndokrinologii
#32
JOURNAL ARTICLE
De- Kang Huang, Ze-Hua Liu, Yi-Ping Wan, Zhi Dang
Phthalic acid ester (PAE) contamination in popular drink bubble tea has been hardly studied in the world. In this work, a liquid-liquid extraction following solid phase extraction (LLE-SPE)-UPLC-MS/MS method was first established for trace determination of ten PAEs in bubble tea. The developed method was validated with respect to linearity (R2 > 0.992), low limit of detections (LODs, 0.49-3.16 µg/L), and satisfactory recoveries (61.8-127.6%) with a low relative standard derivations (RSDs, 1...
September 8, 2023: Environmental Science and Pollution Research International
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JOURNAL ARTICLE
Manas Jyoti Das, Dipanjan Banerjee, Amartya Banerjee, Sangita Muchahary, Archana Sinha, Debananda Gogoi, Pronobesh Chattopadhyay, Suman Dasgupta, Sankar Chandra Deka
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes and its complications have overwhelmed India's healthcare system. Current therapies are expensive and have adverse side effects, thus dietary changes and alternative treatments are needed. Lagenaria siceraria (Molina) Standl. Juice is used mainly for its nutritional and medicinal values, however toxicity of the juice and antidiabetic effects have been poorly characterized. AIM OF THE STUDY: To investigate the toxicity, anti-diabetic and anti-inflammatory efficacy of Lagenaria siceraria (Molina) Standl...
September 4, 2023: Journal of Ethnopharmacology
#34
JOURNAL ARTICLE
Ying Sui, Xuwen Zhang, Chenhui Xu, Yibo Shi, Yunfeng Deng, Yang Han, Yanhou Geng
3,4-Difluorothiophene-substituted aryls, i.e., 1,4-bis(3,4-difluorothiophen-2-yl)-benzene (Ph-2FTh), 1,4-bis(3,4-difluorothiophen-2-yl)-2,5-difluorobenzene (2FPh-2FTh) and 4,7-bis(3,4-difluorothiophen-2-yl)-2,1,3-benzothiadiazole (BTz-2FTh), are synthesized as C-H monomers for the synthesis of conjugated polymers (CPs) via direct arylation polycondensation (DArP) with diketopyrrolopyrrole (DPP) and isoindigo (IID) derivatives as C-Br monomers. The Gibbs free energies of activation for direct arylation (ΔG298K , kcal mol-1 ) for α-C-H bonds of thiophene moieties as calculated by density functional theory (DFT) are 14...
August 28, 2023: Macromolecular Rapid Communications
#35
JOURNAL ARTICLE
José Antonio Mora-Melgem, Jesús Gilberto Arámburo-Gálvez, Feliznando Isidro Cárdenas-Torres, Jhonatan Gonzalez-Santamaria, Giovanni Isaí Ramírez-Torres, Aldo Alejandro Arvizu-Flores, Oscar Gerardo Figueroa-Salcido, Noé Ontiveros
Chickpea ( Cicer arietinum L.) peptides can inhibit dipeptidyl peptidase IV (DPP-IV), an important type 2 diabetes mellitus therapeutic target. The molecular interactions between the inhibitory peptides and the active site of DPP-IV have not been thoroughly examined, nor have their pharmacokinetic properties. Therefore, the predictions of legumin- and provicilin-derived DPP-IV inhibitory peptides, their molecular interactions with the active site of DPP-IV, and their pharmacokinetic properties were carried out...
August 4, 2023: Pharmaceuticals
#36
JOURNAL ARTICLE
Jialin Li, Xiaofeng Liu, Wen Li, Di Wu, Zhong Zhang, Wanchao Chen, Yan Yang
Umami peptides from natural resources have garnered considerable attention for their potential bioactivities and flavor-enhancing characteristics. In this study, we constructed a database comprising 123 peptides from Stropharia rugosoannulata and screened for umami peptides with both angiotensin I-converting enzyme (ACE) and dipeptidyl peptidase-4 (DPP-IV) inhibitory activities using online prediction tools and molecular docking, and further confirmed by SPR sensing, intelligent sensory and activities test...
August 9, 2023: Food Chemistry
#37
JOURNAL ARTICLE
Oluwafemi Adeleke Ojo, Akingbolabo Daniel Ogunlakin, Gideon Ampoma Gyebi, Damilare IyinKristi Ayokunle, Adeshina Isaiah Odugbemi, Dare Ezekiel Babatunde, Omolola Adenike Ajayi-Odoko, Matthew Iyobhebhe, Samson Chukwuemeka Ezea, Christopher Oloruntoba Akintayo, Ademola Ayeleso, Adebola Busola Ojo, Omolara Olajumoke Ojo
Introduction: This study aimed to investigate the chemical profile of GC-MS, antioxidant, anti-diabetic, and anti-inflammatory activities of the ethyl acetate fraction of Spilanthes filicaulis leaves (EFSFL) via experimental and computational studies. Methods: After inducing oxidative damage with FeSO4 , we treated the tissues with different concentrations of EFSFL. An in-vitro analysis of EFSFL was carried out to determine its potential for antioxidant, anti-diabetic, and anti-inflammatory activities. We also measured the levels of CAT, SOD, GSH, and MDA...
2023: Frontiers in Pharmacology
#38
JOURNAL ARTICLE
Yaswanth Kuthati, Vaikar Navakanth Rao, Wei-Hsiu Huang, Prabhakar Busa, Chih-Shung Wong
Morphine (MOR) is a commonly prescribed drug for the treatment of moderate to severe diabetic neuropathic pain (DNP). However, long-term MOR treatment is limited by morphine analgesic tolerance (MAT). The activation of microglial cells and the release of glia-derived proinflammatory cytokines are known to play an important role in the development of MAT. In this study, we aimed to investigate the effects of the dipeptidyl peptidase-4 inhibitor (DPP-4i) teneligliptin (TEN) on MOR-induced microglial cell activation and MAT in DNP rats...
July 24, 2023: Antioxidants (Basel, Switzerland)
#39
JOURNAL ARTICLE
Nikolai F Romashev, Ivan V Bakaev, Veronika I Komlyagina, Pavel A Abramov, Irina V Mirzaeva, Vladimir A Nadolinny, Alexander N Lavrov, Nikolai B Kompan'kov, Artem A Mikhailov, Iakov S Fomenko, Alexander S Novikov, Maxim N Sokolov, Artem L Gushchin
A series of iridium complexes with bis(diisopropylphenyl)iminoacenaphtene (dpp-bian) ligands, [Ir(cod)(dpp-bian)Cl] ( 1 ), [Ir(cod)(NO)(dpp-bian)](BF4 )2 ( 2 ) and [Ir(cod)(dpp-bian)](BF4 ) ( 3 ), were prepared and characterized by spectroscopic techniques, elemental analysis, X-ray diffraction analysis and cyclic voltammetry (CV). The structures of 1 - 3 feature a square planar backbone consisting of two C = C π-bonds of 1,5-cyclooctadiene (cod) and two nitrogen atoms of dpp-bian supplemented with a chloride ion (for 1 ) or a NO group (for 2 ) to complete a square-pyramidal geometry...
June 21, 2023: International Journal of Molecular Sciences
#40
JOURNAL ARTICLE
Veronika I Komlyagina, Nikolai F Romashev, Victoria K Besprozvannykh, Jemma Arakelyan, Chengnan Wu, Alexey S Chubarov, Ivan V Bakaev, Yee Kiat Soh, Pavel A Abramov, Kin Leung Cheung, Nikolai B Kompan'kov, Aleksey A Ryadun, Maria V Babak, Artem L Gushchin
A series of heteroleptic bipyridine Pd(II) complexes based on 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene (dpp-Bian) or 1,2-bis[(2,4,6-trimethylphenyl)imino]acenaphthene (tmp-Bian) were prepared. All complexes were fully characterized by spectrochemical methods, and their crystal structures were confirmed by X-ray diffraction analysis. The 72 h stability of heteroleptic bipyridine Pd(II) complexes with Bian ligands under physiological conditions was investigated using 1 H NMR spectroscopy. The anticancer activity of all complexes was assessed in a panel of cancer cell lines in comparison with uncoordinated ligands and clinically used drugs cisplatin and doxorubicin...
July 7, 2023: Inorganic Chemistry
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