Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Xiaotong Wang, Andrea Rowan-Carroll, Matthew J Meier, Carole L Yauk, Michael G Wade, Bernard Robaire, Barbara F Hales
Organophosphate esters (OPEs), used as flame retardants and plasticizers, are present ubiquitously in the environment. Previous studies suggest that exposure to OPEs is detrimental to female fertility in humans. However, no experimental information is available on the effects of OPE mixtures on ovarian granulosa cells, which play essential roles in female reproduction. We used high-content imaging to investigate the effects of environmentally relevant OPE mixtures on KGN human granulosa cell phenotypes. Perturbations to steroidogenesis were assessed using ELISA and qRT-PCR...
April 11, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
#2
REVIEW
Markus Blümel, Ruth Cordoba-Rodriguez, James A Carroll, Richard Beardsley, Frank Maggio, David Wylie, Valerie Tsang, Robin Ehrick, Bernard Francq, Thomas Pohl, Sonia Taktak, Andy Spasoff, Amy Morrison, Methal Albarghouthi
The comparability assessment of a biological product after implementing a manufacturing process change should involve a risk-based approach. Process changes may occur at any stage of the product lifecycle: early development, clinical manufacture for pivotal trials, or post-approval. The risk of the change to impact product quality varies. The design of the comparability assessment should be adapted accordingly.
February 17, 2024: Journal of Pharmaceutical Sciences
#3
REVIEW
Jiaxi Yong, Miaomiao Wu, Bernard J Carroll, Zhi Ping Xu, Run Zhang
Plant biotechnology plays a crucial role in developing modern agriculture and plant science research. However, the delivery of exogenous genetic material into plants has been a long-standing obstacle. Nanoparticle-based delivery systems are being established to address this limitation and are proving to be a feasible, versatile, and efficient approach to facilitate the internalization of functional RNA and DNA by plants. The nanoparticle-based delivery systems can also be designed for subcellular delivery and controlled release of the biomolecular cargo...
February 5, 2024: Trends in Genetics: TIG
#4
JOURNAL ARTICLE
Rebecca M Degnan, Louise S Shuey, Julian Radford-Smith, Donald M Gardiner, Bernard J Carroll, Neena Mitter, Alistair R McTaggart, Anne Sawyer
Fungal pathogens that impact perennial plants or natural ecosystems require management strategies beyond fungicides and breeding for resistance. Rust fungi, some of the most economically and environmentally important plant pathogens, have shown amenability to double-stranded RNA (dsRNA) mediated control. To date, dsRNA treatments have been applied prior to infection or together with the inoculum. Here we show that a dsRNA spray can effectively prevent and cure infection by Austropuccinia psidii (cause of myrtle rust) at different stages of the disease cycle...
December 6, 2023: Communications Biology
#5
JOURNAL ARTICLE
Xiaotong Wang, Andrea Rowan-Carroll, Matthew J Meier, Andrew Williams, Carole L Yauk, Barbara F Hales, Bernard Robaire
Despite the growing number of studies reporting potential risks associated with exposure to organophosphate esters (OPEs), their molecular mechanisms of action remain poorly defined. We used the high-throughput TempO-Seq™ platform to investigate the effects of frequently detected OPEs on the expression of ∼3000 environmentally responsive genes in KGN human ovarian granulosa cells. Cells were exposed for 48 h to one of five OPEs (0.1 to 50 μM): tris(methylphenyl) phosphate (TMPP), isopropylated triphenyl phosphate (IPPP), tert-butylphenyl diphenyl phosphate (BPDP), triphenyl phosphate (TPHP), or tris(2-butoxyethyl) phosphate (TBOEP)...
November 6, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
#6
JOURNAL ARTICLE
Jerome R Lechien, Michael F Vaezi, Walter W Chan, Jacqueline E Allen, Petros D Karkos, Sven Saussez, Kenneth W Altman, Milan R Amin, Tareck Ayad, Maria R Barillari, Peter C Belafsky, Joel H Blumin, Nikki Johnston, Francois Bobin, Matthew Broadhurst, Fabio P Ceccon, Christian Calvo-Henriquez, Young-Gyu Eun, Carlos M Chiesa-Estomba, Lise Crevier-Buchman, John O Clarke, Giovanni Dapri, Claudia A Eckley, Camille Finck, P Marco Fisichella, Abdul-Latif Hamdan, Stephane Hans, Kathy Huet, Rui Imamura, Blair A Jobe, Toshitaka Hoppo, Lance P Maron, Vinciane Muls, Ashli K O'Rourke, Paulo S Perazzo, Gregory Postma, Vyas M N Prasad, Marc Remacle, Geraldo D Sant'Anna, Robert T Sataloff, Edoardo V Savarino, Antonio Schindler, Nora Siupsinskiene, Ping-Huei Tseng, Craig H Zalvan, Karol Zelenik, Bernard Fraysse, Jonathan M Bock, Lee M Akst, Thomas L Carroll
OBJECTIVE: The objective of this work was to gather an international consensus group to propose a global definition and diagnostic approach of laryngopharyngeal reflux (LPR) to guide primary care and specialist physicians in the management of LPR. METHODS: Forty-eight international experts (otolaryngologists, gastroenterologists, surgeons, and physiologists) were included in a modified Delphi process to revise 48 statements about definition, clinical presentation, and diagnostic approaches to LPR...
November 6, 2023: Laryngoscope
#7
REVIEW
Christopher W G Mann, Anne Sawyer, Donald M Gardiner, Neena Mitter, Bernard J Carroll, Andrew L Eamens
Our duty to conserve global natural ecosystems is increasingly in conflict with our need to feed an expanding population. The use of conventional pesticides not only damages the environment and vulnerable biodiversity but can also still fail to prevent crop losses of 20-40% due to pests and pathogens. There is a growing call for more ecologically sustainable pathogen control measures. RNA-based biopesticides offer an eco-friendly alternative to the use of conventional fungicides for crop protection. The genetic modification (GM) of crops remains controversial in many countries, though expression of transgenes inducing pathogen-specific RNA interference (RNAi) has been proven effective against many agronomically important fungal pathogens...
August 3, 2023: International Journal of Molecular Sciences
#8
REVIEW
Joseph L Pegler, Jackson M J Oultram, Christopher W G Mann, Bernard J Carroll, Christopher P L Grof, Andrew L Eamens
Angiosperms form the largest phylum within the Plantae kingdom and show remarkable genetic variation due to the considerable difference in the nuclear genome size of each species. Transposable elements (TEs), mobile DNA sequences that can amplify and change their chromosome position, account for much of the difference in nuclear genome size between individual angiosperm species. Considering the dramatic consequences of TE movement, including the complete loss of gene function, it is unsurprising that the angiosperms have developed elegant molecular strategies to control TE amplification and movement...
March 1, 2023: Plants (Basel, Switzerland)
#9
JOURNAL ARTICLE
Rebecca M Degnan, Alistair R McTaggart, Louise S Shuey, Leny Jane S Pame, Grant R Smith, Donald M Gardiner, Volker Nock, Rebecca Soffe, Sarah Sale, Ashley Garrill, Bernard J Carroll, Neena Mitter, Anne Sawyer
Rust fungi (Pucciniales) are a diverse group of plant pathogens in natural and agricultural systems. They pose ongoing threats to the diversity of native flora and cause annual crop yield losses. Agricultural rusts are predominantly managed with fungicides and breeding for resistance, but new control strategies are needed on non-agricultural plants and in fragile ecosystems. RNA interference (RNAi) induced by exogenous double-stranded RNA (dsRNA) has promise as a sustainable approach for managing plant-pathogenic fungi, including rust fungi...
December 17, 2022: Molecular Plant Pathology
#10
JOURNAL ARTICLE
Rauan Kaiyrzhanov, Maha S Zaki, Tracy Lau, Sambuddha Sen, Reza Azizimalamiri, Mina Zamani, Gözde Yeşil Sayin, Taru Hilander, Stephanie Efthymiou, Viorica Chelban, Ruth Brown, Kyle Thompson, Maria Irene Scarano, Jaya Ganesh, Kairgali Koneev, Ismail Musab Gülaçar, Richard Person, Dinara Sadykova, Yerdan Maidyrov, Tahereh Seifi, Aizhan Zadagali, Geneviève Bernard, Katrina Allis, Houda Zghal Elloumi, Amanda Lindy, Ehsan Taghiabadi, Sumit Verma, Rachel Logan, Brian Kirmse, Renkui Bai, Shaimaa M Khalaf, Mohamed S Abdel-Hamid, Alireza Sedaghat, Gholamreza Shariati, Mahmoud Issa, Jawaher Zeighami, Hasnaa M Elbendary, Garry Brown, Robert W Taylor, Hamid Galehdari, Joseph J Gleeson, Christopher J Carroll, James A Cowan, Andres Moreno-De-Luca, Henry Houlden, Reza Maroofian
Bi-allelic variants in Iron-Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early-onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra-rare bi-allelic NFU1 missense variants associated with a spectrum of early-onset pure to complex hereditary spastic paraplegia (HSP) phenotype with a longer survival (16/19) on one end and neurodevelopmental delay with severe hypotonia (3/19) on the other...
October 18, 2022: Annals of Clinical and Translational Neurology
#11
JOURNAL ARTICLE
Louisa Matthew, Melquiades E C Reyes, Christopher W G Mann, Alasdair W McDowall, Andrew L Eamens, Bernard J Carroll
Most flowering plant species contain at least two copies of the DEFECTIVE EMBRYO AND MERISTEMS ( DEM ) gene with the encoded DEM proteins lacking homology to proteins of known biochemical function. In tomato ( Sl ; Solanum lycopersicum ), stable mutations in the SlDEM1 locus result in shoot and root meristem defects with the dem1 mutant failing to progress past the cotyledon stage of seedling development. Generation of a Somatic Mutagenesis of DEM1 ( SMD ) transformant line in tomato allowed for the characterization of SlDEM1 gene function past the seedling stage of vegetative development with SMD plants displaying a range of leaf development abnormalities...
September 28, 2022: Plants (Basel, Switzerland)
#12
JOURNAL ARTICLE
Jiaxi Yong, Miaomiao Wu, Run Zhang, Shengnan Bi, Christopher W G Mann, Neena Mitter, Bernard J Carroll, Zhi Ping Xu
RNA interference is triggered in plants by the exogenous application of double-stranded RNA (dsRNA) or small interfering RNA (siRNA) to silence the expression of target genes. This approach can potentially provide insights into metabolic pathways and gene function and afford plant protection against viruses and other plant pathogens. However, the effective delivery of biomolecules such as siRNA into plant cells is difficult because of the unique barrier imposed by the plant cell wall. Here, we demonstrate that 40 nm layered double hydroxide (LDH) nanoparticles are rapidly taken up by intact Nicotiana benthamiana leaf cells and by chloroplasts, following their application via infiltration...
September 22, 2022: Plant Physiology
#13
JOURNAL ARTICLE
Johanna Raidt, Bernard Maitre, Petra Pennekamp, Josje Altenburg, Pinelopi Anagnostopoulou, Miguel Armengot, Lizan D Bloemsma, Mieke Boon, Melissa Borrelli, Folke Brinkmann, Siobhan B Carr, Mary P Carroll, Silvia Castillo-Corullón, André Coste, Renato Cutrera, Eleonora Dehlink, Damien M S Destouches, Maria E Di Cicco, Lucy Dixon, Nagehan Emiralioglu, Ela Erdem Eralp, Eric G Haarman, Claire Hogg, Bulent Karadag, Helene E Kobbernagel, Natalie Lorent, Marcus A Mall, June K Marthin, Vendula Martinu, Manjith Narayanan, Ugur Ozcelik, Daniel Peckham, Massimo Pifferi, Petr Pohunek, Eva Polverino, Simon Range, Felix C Ringshausen, Evie Robson, Jobst Roehmel, Sandra Rovira-Amigo, Francesca Santamaria, Anne Schlegtendal, Zsolt Szépfalusi, Petra Tempels, Guillaume Thouvenin, Nicola Ullmann, Woolf T Walker, Martin Wetzke, Panayiotis Yiallouros, Heymut Omran, Kim G Nielsen
Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by impaired mucociliary clearance leading to irreversible lung damage. In contrast to other rare lung diseases like cystic fibrosis (CF), there are only few clinical trials and limited evidence-based treatments. Management is mainly based on expert opinions and treatment is challenging due to a wide range of clinical manifestations and disease severity. To improve clinical and translational research and facilitate development of new treatments, the clinical trial network for PCD (PCD-CTN) was founded in 2020 under the framework of the European Reference Network (ERN)-LUNG PCD Core...
July 2022: ERJ Open Research
#14
JOURNAL ARTICLE
Stephen J Fletcher, Jonathan R Peters, Cristian Olaya, Denis M Persley, Ralf G Dietzgen, Bernard J Carroll, Hanu Pappu, Neena Mitter
Tospoviruses infect numerous crop species worldwide, causing significant losses throughout the supply chain. As a defence mechanism, plants use RNA interference (RNAi) to generate virus-derived small-interfering RNAs (vsiRNAs), which target viral transcripts for degradation. Small RNA sequencing and in silico analysis of capsicum and N. benthamiana infected by tomato spotted wilt virus (TSWV) or capsicum chlorosis virus (CaCV) demonstrated the presence of abundant vsiRNAs, with host-specific differences evident for each pathosystem...
June 30, 2022: Pathogens
#15
JOURNAL ARTICLE
Daniel Demant, Julie-Anne Carroll, Bernard Saliba, Adam Bourne
Introduction: Chemsex refers to using illicit substances to facilitate sexual experiences in men who have sex with men. Chemsex has been linked to significant negative impacts on psychological, social, and physical wellbeing. Little is known about information-seeking behaviours in this population. This study aims to provide an in-depth understanding of seeking and engaging with health information. Methods: Self-identified Australian sexual minority men who engage in chemsex (N = 184) participated in an anonymous cross-sectional survey...
December 2022: Addictive Behaviors Reports
#16
JOURNAL ARTICLE
Phillip Yeoh, Andrew A Dwyer, Ella Anghel, Pierre M Bouloux, Bernard Khoo, Shern Chew, Florian Wernig, Paul Carroll, Simon J B Aylwin, Stephanie E Baldeweg, William Drake, Jeannie Todd, Lindiwe Mangena, Ashley Grossman
OBJECTIVE: The insulin tolerance test (ITT) is the gold standard endocrine test used to assess the integrity of the growth hormone (GH) and cortisol axes. The ITT has potential risks, and severe hypoglycaemia may necessitate intravenous glucose rescue. There is no clear consensus as to the optimal insulin dose for the ITT. Therefore, we sought to compare the standard dose (0.15 U/kg) and a low-dose ITT (0.1 U/kg). DESIGN: Single-centre audit of ITT data (2012-2021)...
2022: International Journal of Endocrinology
#17
JOURNAL ARTICLE
George A Stamatiades, Chirine Toufaily, Han Kyeol Kim, Xiang Zhou, Iain R Thompson, Rona S Carroll, Min Chen, Lee S Weinstein, Stefan Offermanns, Ulrich Boehm, Daniel J Bernard, Ursula B Kaiser
GnRH regulates gonadal function via its stimulatory effects on gonadotropin production by pituitary gonadotrope cells. GnRH is released from the hypothalamus in pulses and GnRH pulse frequency differentially regulates FSH and LH synthesis and secretion. The GnRH receptor (GnRHR) is a G protein-coupled receptor that canonically activates Gαq/11-dependent signaling upon ligand binding. However, the receptor can also couple to Gαs and in vitro data suggest that toggling between different G proteins may contribute to GnRH pulse frequency decoding...
December 5, 2021: Endocrinology
#18
JOURNAL ARTICLE
Andreas Neff, Niall McLeod, Frederik Spijkervet, Merle Riechmann, Ulla Vieth, Andreas Kolk, Andrew J Sidebottom, Bernard Bonte, Bernard Speculand, Carrol Saridin, Christian T Wilms, Constantinus Politis, David Faustino Ângelo, Dušan Hirjak, Esben Aagaard, Fabrizio Spallaccia, Florencio Monje, Gerhard Undt, Giovanni Gerbino, Hadas Lehman, Jacinto F Sanromán, Louis G Mercuri, Luke Cascarini, Mattias Ulmner, Maurice Mommaerts, Nadeem R Saeed, Orhan Güven, Salvatore Sembronio, Vladimir Machoň, Linda Skroch
Although condylar dislocation is not uncommon, terminology, diagnostics, and treatment concepts vary considerably worldwide. This study aims to present a consensus recommendation based on systematically reviewed literature and approved by the European Society of TMJ Surgeons (ESTMJS). Based on the template of the evidence-based German guideline (register # 007-063) the ESTMJS members voted on 30 draft recommendations regarding terminology, diagnostics, and treatment initially via a blinded modified Delphi procedure...
October 29, 2021: Journal of Clinical Medicine
#19
JOURNAL ARTICLE
Jerome R Lechien, Thomas L Carroll, Géraldine Nowak, Kathy Huet, Bernard Harmegnies, Alain Lechien, Mihaela Horoi, Didier Dequanter, Serge D Le Bon, Sven Saussez, Stéphane Hans, Alexandra Rodriguez
OBJECTIVES: To analyze pre to posttreatment voice changes regarding the type of reflux in patients with acid, weakly acid or alkaline laryngopharyngeal reflux (LPR). METHODS: Patients with LPR, diagnosed using hypopharyngeal-esophageal multichannel intraluminal impedance pH-monitoring (HEMII-pH), were prospectively recruited from three University Hospitals. Patients were treated with a combination of diet, proton pump inhibitors, magaldrate and alginate for 3 months...
October 23, 2021: Journal of Voice
#20
JOURNAL ARTICLE
Jiaxi Yong, Run Zhang, Shengnan Bi, Peng Li, Luyao Sun, Neena Mitter, Bernard J Carroll, Zhi Ping Xu
Topical application of double-stranded RNA (dsRNA) can induce RNA interference (RNAi) and modify traits in plants without genetic modification. However, delivering dsRNA into plant cells remains challenging. Using developing tomato (Solanum lycopersicum) pollen as a model plant cell system, we demonstrate that layered double hydroxide (LDH) nanoparticles up to 50 nm in diameter are readily internalized, particularly by early bicellular pollen, in both energy-dependent and energy-independent manners and without physical or chemical aids...
October 5, 2021: Plant Physiology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
