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JOURNAL ARTICLE
Sofia Kalaidopoulou Nteak, Franziska Völlmy, Marie V Lukassen, Henk van den Toorn, Maurits A den Boer, Albert Bondt, Sjors P A van der Lans, Pieter-Jan Haas, Arjan D van Zuilen, Suzan H M Rooijakkers, Albert J R Heck
Using proteomics and complexome profiling, we evaluated in a year-long study longitudinal variations in the plasma proteome of kidney failure patients, prior to and after a kidney transplantation. The post-transplant period was complicated by bacterial infections, resulting in dramatic changes in the proteome, attributed to an acute phase response (APR). As positive acute phase proteins (APPs), being elevated upon inflammation, we observed the well-described C-reactive protein and Serum Amyloid A (SAA), but also Fibrinogen, Haptoglobin, Leucine-rich alpha-2-glycoprotein, Lipopolysaccharide-binding protein, Alpha-1-antitrypsin, Alpha-1-antichymotrypsin, S100, and CD14...
May 3, 2024: Journal of Proteome Research
#2
JOURNAL ARTICLE
Andrew P Bontemps, Sofia Mildrum Chana, Elizabeth S Hawes, Yoser Al Rawi, Christina E Cenczyk, Lindsey R Atkins, Li Li, Karen L Cropsey
INTRODUCTION: Opioid use disorder (OUD) is a significant cause of opioid-related fatality, and while medications to treat OUD (MOUD) are effective, disparities remain in the access and uptake of such medications. This study investigated factors that may influence referral to and initiation of MOUD treatment. METHODS: Data from electronic medical records of 677 patients with a history of criminal legal system involvement in a recovery program were used to examine the flow of MOUD referral...
2024: Journal of Opioid Management
#3
JOURNAL ARTICLE
Verónica Cabreira, Jane Alty, Sonja Antic, Rui Araújo, Selma Aybek, Harriet A Ball, Gaston Baslet, Rohan Bhome, Jan Coebergh, Bruno Dubois, Mark Edwards, Saša R Filipović, Kristian Steen Frederiksen, Thomas Harbo, Bradleigh Hayhow, Robert Howard, Jonathan Huntley, Jeremy Isaacs, William Curt LaFrance, Andrew J Larner, Francesco Di Lorenzo, James Main, Elizabeth Mallam, Camillo Marra, João Massano, Emer R McGrath, Laura McWhirter, Isabel Portela Moreira, Flavio Nobili, Catherine Pennington, Miguel Tábuas-Pereira, David L Perez, Stoyan Popkirov, Dane Rayment, Martin Rossor, Mirella Russo, Isabel Santana, Jonathan Schott, Emmi P Scott, Ricardo Taipa, Michele Tinazzi, Svetlana Tomic, Sofia Toniolo, Caroline Winther Tørring, Tim Wilkinson, Lisbeth Frostholm, Jon Stone, Alan Carson
BACKGROUND: Current proposed criteria for functional cognitive disorder (FCD) have not been externally validated. We sought to analyse the current perspectives of cognitive specialists in the diagnosis and management of FCD in comparison with neurodegenerative conditions. METHODS: International experts in cognitive disorders were invited to assess seven illustrative clinical vignettes containing history and bedside characteristics alone. Participants assigned a probable diagnosis and selected the appropriate investigation and treatment...
May 3, 2024: European Journal of Neurology
#4
JOURNAL ARTICLE
Federico Frezza, Ana Sánchez-Grande, Sofia Canola, Anna Lamancová, Pingo Mutombo, Qifan Chen, Christian Wäckerlin, Karl-Heinz Ernst, Matthias Muntwiler, Nicola Zema, Marco Di Giovannantonio, Dana Nachtigallová, Pavel Jelínek
On-surface synthesis has become a prominent method for growing low-dimensional carbon-based nanomaterials on metal surfaces. However, the necessity of decoupling organic nanostructures from metal substrates to exploit their properties requires either transfer methods or new strategies to perform reactions directly on inert surfaces. The use of on-surface light-induced reactions directly on semiconductor/insulating surfaces represents an alternative approach to address these challenges. Here, exploring the photochemical activity of different organic molecules on a SnSe semiconductor surface under ultra-high vacuum, we present a novel on-surface light-induced reaction...
May 3, 2024: Angewandte Chemie
#5
JOURNAL ARTICLE
Brisa García-Vilchis, Talia V Román-López, Diego Ramírez-González, Xanat J López-Camaño, Vanessa Murillo-Lechuga, Xóchitl Díaz-Téllez, C Itzamná Sánchez-Moncada, Ian M Espinosa-Méndez, Diego Zenteno-Morales, Zaida X Espinosa-Valdes, Sofia Pradel-Jiménez, Andrea Tapia-Atilano, Ana V Zanabria-Pérez, Federica Livas-Gangas, Oscar Aldana-Assad, Ulises Caballero-Sánchez, César A Dominguez-Frausto, Miguel E Rentería, Alejandra Medina-Rivera, Sarael Alcauter, Alejandra E Ruiz-Contreras
TwinsMX registry is a national research initiative in Mexico that aims to understand the complex interplay between genetics and environment in shaping physical and mental health traits among the country's population. With a multidisciplinary approach, TwinsMX aims to advance our knowledge of the genetic and environmental mechanisms underlying ethnic variations in complex traits and diseases, including behavioral, psychometric, anthropometric, metabolic, cardiovascular and mental disorders. With information gathered from over 2800 twins, this article updates the prevalence of several complex traits; and describes the advances and novel ideas we have implemented such as magnetic resonance imaging...
May 3, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
#6
REVIEW
Nesrine Lajmi, Sofia Alves-Vasconcelos, Apostolos Tsiachristas, Andrew Haworth, Kerrie Woods, Charles Crichton, Theresa Noble, Hizni Salih, Kinga A Várnai, Harriet Branford-White, Liam Orrell, Andrew Osman, Kevin M Bradley, Lara Bonney, Daniel R McGowan, Jim Davies, Matthew S Prime, Andrew Bassim Hassan
The personalised oncology paradigm remains challenging to deliver despite technological advances in genomics-based identification of actionable variants combined with the increasing focus of drug development on these specific targets. To ensure we continue to build concerted momentum to improve outcomes across all cancer types, financial, technological and operational barriers need to be addressed. For example, complete integration and certification of the 'molecular tumour board' into 'standard of care' ensures a unified clinical decision pathway that both counteracts fragmentation and is the cornerstone of evidence-based delivery inside and outside of a research setting...
2024: Camb Prism Precis Med
#7
JOURNAL ARTICLE
Sofia Morais, Otília C d'Almeida, Salomé Caldeira, Sofia Meneses, Graça Areias, Vanessa Girão, Catarina Bettencourt, Daniela Jardim Pereira, António Macedo, Miguel Castelo-Branco
The profile of executive function (EF) in adults with Schizophrenia (SCZ) and autism spectrum disorder (ASD) remains unclear. This study aims to ascertain if distinct EF patterns can be identified between each clinical condition by comparing the neuropsychological profile of adults with SCZ and ASD, for whom the differential diagnosis is still highly challenging. Forty-five individuals (15 SCZ, 15 ASD, 15 controls) matched for age, sex, education level, and handedness underwent intelligence evaluation and neuropsychological testing for working memory, inhibition, planning and set-shifting, and verbal fluency subdomains...
2024: Frontiers in Psychiatry
#8
JOURNAL ARTICLE
Hala Zakaria, Sheikha Alshehhi, Milena Caccelli, Cigdem Ozkan, Judy Kattan, Zeinab Jafaar, Remie Laborte, Sofia Aleabova, Noah Almarzooqi, Ali Hashemi, Ihsan Almarzooqi
AIM: Emerging anti-obesity pharmacotherapy provides an option to correct maladaptive physiological and hormonal changes associated with obesity. One of the widely used medications in this context is glucagon-like peptide 1 (GLP-1) agonists. However, the misuse of these medications without any guidance and monitoring of lifestyle modifications can lead to unfavorable outcomes. The study aims to evaluate the effectiveness of a hybrid care model, incorporating GLP-1 and GLP-1/GIP agonist therapies, in managing obese patients with/without pre-diabetes...
June 2024: Metabolism open
#9
JOURNAL ARTICLE
Freya C Womersley, Christoph A Rohner, Katya Abrantes, Pedro Afonso, Shin Arunrugstichai, Steffen S Bach, Shir Bar, Adi Barash, Peter Barnes, Adam Barnett, Ginevra Boldrocchi, Noemie Buffat, Tom Canon, Clara Canovas Perez, Metavee Chuangcharoendee, Jesse E M Cochran, Rafael de la Parra, Stella Diamant, William Driggers, Christine Dudgeon, Mark V Erdmann, Richard Fitzpatrick, Anna Flam, Jorge Fontes, Gemma Francis, Beatriz Eugenia Galvan, Rachel Graham, Sofia M Green, Jonathan R Green, Ya'ara Grosmark, Hector M Guzman, Royale S Hardenstine, Maria Harvey, Jessica Harvey-Carroll, Abdi Wunanto Hasan, Alex R Hearn, Jill M Hendon, Mochamad Iqbal Herwata Putra, Mahardika Rizqi Himawan, Eric Hoffmayer, Jason Holmberg, Hua Hsun Hsu, Mohammed Y Jaidah, Ashlee Jansen, Christy Judd, Baraka Kuguru, Emily Lester, Bruno C L Macena, Kirsty Magson, Rossana Maguiño, Mabel Manjaji-Matsumoto, Stacia Marcoux, Travis Marcoux, Jennifer McKinney, Mark Meekan, Alejandra Mendoza, Muhammad Moazzam, Emily Monacella, Brad Norman, Cameron Perry, Simon Pierce, Clare Prebble, Dení Ramírez Macías, Holly Raudino, Samantha Reynolds, David Robinson, David Rowat, Mudjekeewis D Santos, Jennifer Schmidt, Chad Scott, Sian Tian See, Abraham Sianipar, Conrad W Speed, Ismail Syakurachman, Julian A Tyne, Kelly Waples, Chloe Winn, Ranny R Yuneni, Irthisham Zareer, Gonzalo Araujo
The expansion of the world's merchant fleet poses a great threat to the ocean's biodiversity. Collisions between ships and marine megafauna can have population-level consequences for vulnerable species. The Endangered whale shark (Rhincodon typus), shares a circumglobal distribution with this expanding fleet and tracking of movement pathways has shown that large vessel collisions pose a major threat to the species. However, it is not yet known whether they are also at risk within aggregation sites, where up to 400 individuals can gather to feed on seasonal bursts of planktonic productivity...
April 30, 2024: Science of the Total Environment
#10
JOURNAL ARTICLE
Angel N Desai, Marion Koopmans, Ashley Otter, Martin P Grobusch, Pikka Jokelainen, Barry Atkinson, Flavia Cunha, Sofia R Valdoleiros, Veronica G Preda, Francesco Maria Fusco, Chantal P Rovers, Gilbert Greub, Antonino Di Caro, Lone Simonsen, Francine Ntoumi, Eskild Petersen
No abstract text is available yet for this article.
April 30, 2024: Clinical Microbiology and Infection
#11
JOURNAL ARTICLE
Bárbara Lacerda Teixeira, Pedro Silva Cunha, Ana Sofia Jacinto, Guilherme Portugal, Sérgio Laranjo, Bruno Valente, Ana Lousinha, Madalena Coutinho Cruz, Ana Sofia Delgado, Manuel Brás, Margarida Paulo, Cátia Guerra, Ruben Ramos, Iládia Fontes, Rui Cruz Ferreira, Mário Martins Oliveira
INTRODUCTION: In patients with atrial fibrillation (AF), up to one third have recurrence after a first catheter ablation (CA). Epicardial adipose tissue (EAT) has been considered to be closely related to AF, with a potential role in its recurrence. We aimed to evaluate the association between the volume of EAT measured by cardiac computed tomography (CT) and AF recurrence after CA. METHODS: Consecutive AF patients underwent a standardized cardiac CT protocol for quantification of EAT, thoracic adipose volume (TAV) and left atrium (LA) volume before CA...
April 28, 2024: Clinical Imaging
#12
JOURNAL ARTICLE
Sofia Olofsson, Fredric Karlsson, Miriam Pikkemaat, Björn Ekman, Mattias Rööst, Hans Thulesius, Veronica Milos Nymberg
OBJECTIVES: To describe changes in Swedish primary care physicians' use of, attitudes and intentions toward digital tools in patient care between 2019 and 2022. DESIGN: A survey using a validated questionnaire measuring physician's intentions to use digital tools based on the theory of planned behavior. SETTING: Sample of primary health care centers in southern Sweden. SUBJECTS: Primary care physicians. MAIN OUTCOME MEASURES: Self-reported use and intentions to use, digital tools including digital consultations by text or video, chronic disease monitoring and artificial intelligence (AI) and the associations between attitudes, subjective norms, perceived behavioral control and behavioral intentions to use digital tools, in 2019 compared to 2022...
May 2, 2024: Scandinavian Journal of Primary Health Care
#13
REVIEW
Kayla D Mashoudy, Sofia M Perez, Keyvan Nouri
Skin cancer treatment is a core aspect of dermatology that relies on accurate diagnosis and timely interventions. Teledermatology has emerged as a valuable asset across various stages of skin cancer care including triage, diagnosis, management, and surgical consultation. With the integration of traditional dermoscopy and store-and-forward technology, teledermatology facilitates the swift sharing of high-resolution images of suspicious skin lesions with consulting dermatologists all-over. Both live video conference and store-and-forward formats have played a pivotal role in bridging the care access gap between geographically isolated patients and dermatology providers...
May 2, 2024: Archives of Dermatological Research
#14
JOURNAL ARTICLE
Astrid Kolind Christensen, Charlotte Egeland, Jens Bjoern Heje, Sofia Kamakh Asaad, Roberto Loprete, Trygve Ulvund Solstad, Daniel Kjaer, Sarunas Dikinis, Michael P Achiam
BACKGROUND: The surgical treatment of gastric and esophageal cancer in Denmark is centralized in four specialized esophagogastric cancer (EGC) centers. Patients are referred after an esophagogastroduodenoscopy (EGD) at a secondary healthcare facility. The EGD is repeated at the specialized EGC center before determining a surgical treatment strategy. This multicenter retrospective study aimed to investigate the quality of EGDs performed at a secondary healthcare facility and evaluate the clinical value of repeated EGD at a specialized center when determining the surgical treatment strategy...
May 2, 2024: Scandinavian Journal of Surgery: SJS
#15
JOURNAL ARTICLE
Sean Dreyer, Christopher Lewis, Kyle Fahey, Hannah Martin, Larissa Pavone, Sofia Anastasopoulos, Gaurish Sohi, Leslie Rydberg, Prakash Jayabalan
BACKGROUND: Survivors of hospitalization for severe acute COVID-19 infection faced significant functional impairments necessitating discharge to inpatient rehabilitation facilities (IRFs) for intensive rehabilitation prior to discharge home. There remains a lack of large cohort studies of the functional outcomes of patients admitted to IRFs with COVID-19-related impairments and the relationship to patient-specific factors. OBJECTIVE: To characterize functional outcomes of patients admitted to IRFs for COVID-19-related debility and to investigate associations between functional outcomes and patient-specific factors...
May 2, 2024: PM & R: the Journal of Injury, Function, and Rehabilitation
#16
JOURNAL ARTICLE
Sofia Bragança, Luís Carvalho Lourenço, Mariana Cardoso
No abstract text is available yet for this article.
May 2, 2024: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
#17
JOURNAL ARTICLE
Hilde K R Riise, Jannicke Igland, Marit Graue, Anne Haugstvedt, Truls Østbye, Eirik Søfteland, Monica Hermann, Sofia Carlsson, Bjørn Olav Åsvold, Marjolein M Iversen
BACKGROUND AND AIMS: Diabetes-related foot ulcers (DFU) are a persistent healthcare challenge, impacting both patients and healthcare systems, with adverse effects on quality of life and productivity. Our primary aim was to examine the trends in lifetime prevalence of DFU, as well as other micro- and macrovascular complications in the Trøndelag Health Study (HUNT) in Norway. METHODS: This study consists of individuals ≥20 years with diabetes participating in the population-based cross-sectional HUNT surveys (1995-2019)...
2024: Frontiers in Endocrinology
#18
Andreia Coutinho, Inês De Albuquerque Monteiro, Sofia Festa, Sofia Teixeira, Violeta Iglesias
Infectious aortitis is a rare entity with high mortality and should be considered in the presence of persistent bacteremia, especially in the absence of endocarditis. We present the clinical case of a woman who developed aortitis due to methicillin-sensitive Staphylococcus aureus , complicated with mycotic aneurysm and recurrent bacteremia, even under appropriate treatment. Given the concomitant probable diagnosis of malignant pancreatic neoplasia, the hypothesis of a possible relationship or contribution to bacteremia is raised...
April 2024: Curēus
#19
JOURNAL ARTICLE
Danielle Bradley, Sophia Sarpaki, Vincenzo Mirabello, Simone Giuseppe Giuffrida, Gabriele I Kociok-Köhn, David G Calatayud, Sofia I Pascu
Coumarins, methylene blue derivatives, as well as related functional organic dyes have become prevalent tools in life sciences and biomedicine. Their intense blue fluorescence emission makes them ideal agents for a range of applications, yet an unwanted facet of the interesting biological properties of such probes presents a simultaneous environmental threat due to inherent toxicity and persistence in aqueous media. As such, significant research efforts now ought to focus on their removal from the environment, and the sustainable trapping onto widely available, water dispersible and processable adsorbent structures such as graphene oxides could be advantageous...
April 30, 2024: Nanoscale advances
#20
JOURNAL ARTICLE
Theodoros Georgiou, Petros P Petrou, Anna Malekkou, Ioannis Ioannou, Marina Gavatha, Nicos Skordis, Paola Nicolaidou, Irini Savvidou, Emilia Athanasiou, Sofia Ourani, Elena Papamichael, Marios Vogazianos, Maria Dionysiou, Gabriella Mavrikiou, Olga Grafakou, George A Tanteles, Violetta Anastasiadou, Anthi Drousiotou
Selective screening for inherited metabolic disorders (IMD) began in Cyprus in 1990. Over the last thirty-three years 7388 patients were investigated for IMD and 200 diagnoses were made (diagnostic yield 2.7%). The existence of a single laboratory of Biochemical Genetics for the whole island facilitated the creation of a national registry for IMD. The minimal prevalence of IMD in Cyprus is 53.3 cases per 100,000 live births. The most common group are disorders of amino acid metabolism (41.0%), followed by disorders of carbohydrate metabolism (16...
June 2024: Molecular Genetics and Metabolism Reports
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