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Rong Gu, Dandan Zhang, Xiaohong Jin, Wenya Wu, Yunying Hou, Qing Wu, Xiaohua Wang
BACKGROUND: In China, quality of life (QOL) of the elderly with hypertension was lower than that of normal elderly and lower self-perceptions of aging (SPA) in the elderly with chronic diseases have been shown. Previous studies showed that SPA played a key role in QOL of the elderly. We hypothesised that SPA were associated with QOL in Chinese elderly with hypertension, with more negative SPA predicting lower QOL. METHODS: A cross-sectional survey was conducted in one comprehensive hospital, 15 urban community clinics and 22 rural village clinics in Suzhou...
February 20, 2019: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Mark A Clapp, Kaitlyn E James, Sara V Bates, Anjali J Kaimal
BACKGROUND: Unexpected admissions of term neonates to the neonatal intensive care unit (NICU) and unexpected postnatal complications have been proposed as neonatal-focused quality metrics for intrapartum care. Previous studies have noted significant variation in overall hospital NICU admission rates; however, little is known about the influence of obstetric practices on these rates or whether variation among unanticipated admissions in low risk, term neonates can be attributed to systemic hospital practices...
February 13, 2019: American Journal of Obstetrics and Gynecology
Valéria de Lima Kaminski, Joel Henrique Ellwanger, Valeria Sandrim, Alessandra Pontillo, José Artur Bogo Chies
Pre-eclampsia (PE) is a hypertensive disorder that affects an important number of pregnant women worldwide. The exact causes of PE remain poorly understood. However, inflammation and deregulation of innate immune cells, such as natural killer (NK) cells, contribute to PE pathogenesis. Besides, the mother's genetic background also impacts on PE susceptibility. Thus, genetic variants that potentially modify the behaviour of inflammatory cells may help us to understand the causes of PE. Variants of genes encoding NKG2C (expressed in NK cells) and C-C chemokine receptor type 5 (CCR5) (expressed mainly in leucocytes) are important targets in the study of gestational disorders...
February 20, 2019: International Journal of Immunogenetics
Susana Santos, Ellis Voerman, Pilar Amiano, Henrique Barros, Lawrence J Beilin, Anna Bergström, Marie-Aline Charles, Leda Chatzi, Cécile Chevrier, George P Chrousos, Eva Corpeleijn, Olga Costa, Nathalie Costet, Sarah Crozier, Graham Devereux, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Vagelis Georgiu, Keith M Godfrey, Davide Gori, Veit Grote, Wojciech Hanke, Irva Hertz-Picciotto, Barbara Heude, Marie-France Hivert, Daniel Hryhorczuk, Rae-Chi Huang, Hazel Inskip, Anne M Karvonen, Louise C Kenny, Berthold Koletzko, Leanne K Küpers, Hanna Lagström, Irina Lehmann, Per Magnus, Renata Majewska, Johanna Mäkelä, Yannis Manios, Fionnuala M McAuliffe, Sheila W McDonald, John Mehegan, Erik Melén, Monique Mommers, Camilla S Morgen, George Moschonis, Deirdre Murray, Carol Ní Chaoimh, Ellen A Nohr, Anne-Marie Nybo Andersen, Emily Oken, Adriëtte J J M Oostvogels, Agnieszka Pac, Eleni Papadopoulou, Juha Pekkanen, Costanza Pizzi, Kinga Polanska, Daniela Porta, Lorenzo Richiardi, Sheryl L Rifas-Shiman, Nel Roeleveld, Luca Ronfani, Ana C Santos, Marie Standl, Hein Stigum, Camilla Stoltenberg, Elisabeth Thiering, Carel Thijs, Maties Torrent, Suzanne C Tough, Tomas Trnovec, Steve Turner, Marleen M H J van Gelder, Lenie van Rossem, Andrea von Berg, Martine Vrijheid, Tanja G M Vrijkotte, Jane West, Alet H Wijga, John Wright, Oleksandr Zvinchuk, Thorkild I A Sørensen, Debbie A Lawlor, Romy Gaillard, Vincent W V Jaddoe
OBJECTIVE: To assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact. DESIGN: Individual participant data meta-analysis of 39 cohorts. SETTING: Europe, North America and Oceania. POPULATION: 265,270 births. METHODS: Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained...
February 20, 2019: BJOG: An International Journal of Obstetrics and Gynaecology
Michael Girsberger, John Thenganatt, Christopher T Chan
Pulmonary hypertension (PH) defined as a mean pulmonary arterial pressure ≥25 mmHg is a common complication in hemodialysis occurring in up to 58% of patients. PH is classified according to its etiology. We report in a patient with severe PH of mixed etiology (connective tissue disease and left-sided heart failure) who improved after initiation of intensive home hemodialysis. We postulated that the use of a frequent mode of hemodialysis may ameliorate PH via enhanced volume control. Thereby, an intensive hemodialysis schedule may be preferred renal replacement modality in this patient population...
February 20, 2019: Hemodialysis International
Mingxing Chen, Hui Shen, Linlin Zhu, Hongfeng Yang, Peng Ye, Pengfei Liu, Yue Gu, Shaoliang Chen
Hypoxia-induced excessive pulmonary artery smooth muscle cell (PASMC) proliferation plays an important role in the pathology of pulmonary arterial hypertension (PAH). Berberine (BBR) is reported as an effective antiproliferative properties applied in clinical. However, the effect of BBR on PAH remains unclear. In the present study, we elucidated the protective effects of BBR against abnormal PASMC proliferation and vascular remodeling in chronic hypoxia-induced hearts. Furthermore, the potential mechanisms of BBR were investigated...
February 20, 2019: Journal of Cellular Physiology
Ildikó Szőcs, Dániel Bereczki, András Ajtay, Ferenc Oberfrank, Ildikó Vastagh
INTRODUCTION: Hungary has a single payer health insurance system offering free healthcare for acute cerebrovascular disorders. Within the capital, Budapest, however there are considerable microregional socioeconomic differences. We hypothesized that socioeconomic deprivation reflects in less favorable stroke characteristics despite universal access to care. METHODS: From the database of the National Health Insurance Fund, we identified 4779 patients hospitalized between 2002 and 2007 for acute cerebrovascular disease (hereafter ACV, i...
2019: PloS One
Daniel Caldeira, Daniela Alves, João Costa, Joaquim J Ferreira, Fausto J Pinto
INTRODUCTION: Ibrutinib is an oral covalent inhibitor of Bruton's tyrosine kinase approved for the treatment of patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma and Waldenstrӧm's macroglobulinemia. Ibrutinib has an increased risk of atrial fibrillation but the mechanism is unknown, and hypertension may play a role in the pathogenesis of this adverse drug reaction. METHODS: We aimed to review the risk of hypertension and atrial fibrillation as adverse events associated with ibrutinib through a systematic review with meta-analysis of randomized controlled trials (RCTs) retrieved in December 2018 on MEDLINE, EMBASE, CENTRAL and ClinicalTrials...
2019: PloS One
Ida Behrens, Saima Basit, Jacob A Lykke, Mattis F Ranthe, Jan Wohlfahrt, Henning Bundgaard, Mads Melbye, Heather A Boyd
BACKGROUND: Peripartum cardiomyopathy (PPCM) is a serious cardiac disorder occurring late in pregnancy or early in the postpartum period. We examined associations between hypertensive disorders of pregnancy (HDP: preeclampsia and gestational hypertension) and PPCM, accounting for other pregnancy-related risk factors for PPCM. METHODS: Using nationwide Danish register data, we constructed a cohort of all women with ≥1 live birth or stillbirth in Denmark between 1978 and 2012...
2019: PloS One
Chulaporn Limwattananon, Onanong Waleekhachonloet
Under the Universal Coverage Scheme (UCS) with payment per capita for outpatient (OP) services, hospitals' financial risks will rise if access to essential drugs increases. This study examined trends in access to and price of essential drugs for noncommunicable diseases (NCDs) and an overall purchasing price index (PPI) for an OP drug basket from public hospitals. To examine drug access, OP prescription data from 2010-2012 were obtained from the UCS. Access to thirteen drugs for diabetes, hypertension, and dyslipidemia was examined for trend using a time-series analysis...
2019: PloS One
Masayuki Tasaki, Takashi Kasahara, Itsuhiro Takizawa, Kazuhide Saito, Tsutomu Nishiyama, Yoshihiko Tomita
PURPOSE: The purposes of the present study were to evaluate growth rate of nonfunctioning adrenal incidentalomas (AIs) and their development to hormonal hypersecretion on follow-up. MATERIALS AND METHODS: A retrospective study was conducted from the electronic medical records. A total of 314 patients were diagnosed with adrenal tumors between 2000 and 2016. After excluding patients who had overt adrenal endocrine disorders or whose adrenal tumors were clinically diagnosed as metastatic malignancies, we investigated 108 patients with nonfunctioning AIs including characteristics, the treatment, the way of follow-up and pathology...
December 18, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Edward Pivin, Flórido André Cunha Moreira Da Silva, Luca Calanca, Sébastien Deglise, Menno Pruijm
The most frequent dialysis modality in Switzerland is hemodialysis. Patients need a proper vascular access for this modality. There are three types of vascular access for hemodialysis : arteriovenous fistula, arteriovenous graft and central venous catheters. In this article, we will discuss the most important parameters that need to be taken into account when choosing the most appropriate access. We present the advantages and disadvantages of each vascular access, as well as their main local (thrombosis, infection, steal syndrome) and systemic (heart failure, pulmonary hypertension) complications, which may also be encountered by primary care physicians...
February 20, 2019: Revue Médicale Suisse
Jason DeGuire, Janine Clarke, Kaitlyn Rouleau, Joel Roy, Tracey Bushnik
BACKGROUND: Hypertension, or high blood pressure, is a major cause of disability and the leading risk factor for death around the world. Ongoing surveillance is necessary to monitor and assess the population burden of hypertension in Canada. DATA AND METHODS: Using measured data from the Canadian Health Measures Survey, this analysis estimates average systolic blood pressure (BP), average diastolic BP, and hypertension prevalence, awareness, treatment and control in the population aged 20 to 79 years in the period from 2012 to 2015 by sex and age group...
February 20, 2019: Health Reports
Alexander A Leung, Tracey Bushnik, Deirdre Hennessy, Finlay A McAlister, Douglas G Manuel
BACKGROUND: Hypertension (or high blood pressure) affects almost one in four adults in Canada. Quantifying risk factors associated with hypertension may help to inform prevention efforts. DATA AND METHODS: Data from the first four cycles of the Canadian Health Measures Survey (including 13,407 respondents) were used to identify hypertension status by systolic and diastolic blood pressure levels and the use of antihypertensive medications. Logistic regression analysis was employed to estimate the association between six cardiovascular risk factors (individually and as a composite score) and hypertension...
February 20, 2019: Health Reports
David A Hashemi, Zoe O Brown-Joel, Elizabeth Tkachenko, Caroline A Nelson, Megan H Noe, Sotonye Imadojemu, Ruth Ann Vleugels, Arash Mostaghimi, Karolyn A Wanat, Misha Rosenbach
Importance: Necrobiosis lipoidica (NL) is a rare granulomatous condition. Current knowledge of its key features is based on a limited number of studies and case reports, leading to wide variability in the characterization of its defining features, with limited comparison of patients with or without diabetes. Objective: To evaluate the epidemiologic characteristics, clinical features, and disease associations of NL in patients with or without type 1 or 2 diabetes...
February 20, 2019: JAMA Dermatology
Desiderio Favarato, Vera Demarchi Aiello
No abstract text is available yet for this article.
February 2019: Arquivos Brasileiros de Cardiologia
Marcos Vinicius de Araújo Cavalcanti, Luciane Paula Batista Araújo de Oliveira, Anna Cecília Queiroz de Medeiros, Rafaela Carolini de Oliveira Távora
OBJECTIVES: To identify the habits of life in elderly hypertensive men of the city of Currais Novos/RN; correlate life habits and presence of comorbidities. METHODS: An exploratory and descriptive, quantitative study with a sample of 136 elderly hypertensive patients. Data collection took place from August to October 2016, through the structured interview technique. Descriptive and inferential analysis was performed using the Statistical Package for the Social Sciences 20...
February 18, 2019: Revista Gaúcha de Enfermagem
Juliana Arrais Guerra, Kátia Cristina Kampa, Maurício Zapparoli, Venâncio Af Alves, Cláudia Alexandra Pontes Ivantes
The disease and the case reported here are relevant especially because of their varied clinical presentation, possibility of being associated with other disorders affecting several organs and possible differential diagnoses. Congenital Hepatic Fibrosis is an autosomal recessive disease due to mutation in the PKHD1 gene, which encodes the fibrocystin/polyductine protein. It is a cholangiopathy, characterized by varying degrees of periportal fibrosis and irregular proliferation of bile ducts. Affected patients are typically diagnosed in childhood, but in some cases the disease may remain asymptomatic for many years...
October 2018: Arquivos de Gastroenterologia
Qiong Guo, Shanhui Liao, Sebastian Kwiatkowski, Weronika Tomaka, Huijuan Yu, Gao Wu, Xiaoming Tu, Jinrong Min, Jakub Drozak, Chao Xu
SETD3 is a member of the SET (Su(var)3-9, Enhancer of zeste, and Trithorax) domain protein superfamily and plays important roles in hypoxic pulmonary hypertension, muscle differentiation, and carcinogenesis. Previously we identified SETD3 as the actin-specific methyltransferase that methylates the N3 of His73 on β-actin (Kwiatkowski et al. 2018). Here, we present two structures of S -adenosyl-L-homocysteine-bound SETD3 in complex with either an unmodified β-actin peptide or its His-methylated variant. Structural analyses, supported by biochemical experiments and enzyme activity assays, indicate that the recognition and methylation of β-actin by SETD3 are highly sequence specific, and both SETD3 and β-actin adopt pronounced conformational changes upon binding to each other...
February 20, 2019: ELife
Rui Xiao, Liping Zhu, Yuan Su, Jiwei Zhang, Yankai Lu, Jiansha Li, Tao Wang, Jing Fang, Zhi-Cheng Jing, Jocelyn Dupuis, Shengquan Luo, Qinghua Hu
Monocrotaline has been widely used to establish an animal model of pulmonary hypertension, most frequently in rats. An important feature of this model resides in the selectivity of monocrotaline injury towards the pulmonary vascular endothelium versus the systemic vasculature when administrated at standard dosage. The toxic metabolite of monocrotaline, monocrotaline pyrrole, is transported by erythrocytes. This study aimed to reveal whether partial pressure of oxygen of blood determined the binding and release of monocrotaline pyrrole from erythrocytes in rats with one subcutaneous injection of monocrotatline at the standard dosage of 60 mg/Kg...
February 20, 2019: American Journal of Physiology. Lung Cellular and Molecular Physiology
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