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Computational AND Spinal Cord

Mindy X Wang, Garrett Smith, Mehmet Albayram
Spinal cord watershed ischemia is a rare phenomenon often associated with cardiac arrest, prolonged hypotension, and atherosclerotic disease. It can manifest as central necrosis with peripheral sparing in the transverse axis, and central lesion with rostral and caudal sparing in the longitudinal axis. Few reports provide detailed imaging findings of spinal cord watershed ischemia lesions. We present a patient who experienced watershed infarcts of the brain and spinal cord following prolonged hypotension due to blood loss after an aortic aneurysm repair...
January 31, 2019: Clinical Imaging
Soichiro Henmi, Yuki Ikeno, Koki Yokawa, Yasuko Gotake, Hidekazu Nakai, Katsuhiro Yamanaka, Takeshi Inoue, Hiroshi Tanaka, Yutaka Okita
OBJECTIVES: This study aimed to analyse the early patency rate and long-term outcomes of reattached segmental intercostal arteries using graft interposition, single-cuff anastomosis or island reconstruction. METHODS: We selected 172 consecutive patients who underwent open surgery for the thoracoabdominal aorta with reattachment of segmental arteries between October 1999 and March 2018. The early patency of segmental arteries was analysed using enhanced computed tomography...
February 12, 2019: European Journal of Cardio-thoracic Surgery
Daisuke Kaneyuki, Toshihisa Asakura, Atsushi Iguchi, Akihiro Yoshitake, Chiho Tokunaga, Masato Tochii, Hiroyuki Nakajima
OBJECTIVES: Endovascular repair has been proposed as an alternative to classical surgical repair for the management of blunt traumatic thoracic aortic injury. However, the long-term outcomes of endovascular repair and the risks of left subclavian coverage remain unclear. METHODS: From April 2001 to August 2018, 33 patients with blunt traumatic thoracic aortic injury underwent endovascular repair in our institution. A follow-up computed tomography and a clinical examination were performed before discharge and at 1 month, and yearly or every 2 years thereafter...
February 7, 2019: European Journal of Cardio-thoracic Surgery
Yusuke Funakoshi, Junya Hanakita, Toshiyuki Takahashi, Manabu Minami, Taigo Kawaoka, Yasufumi Ohtake, Yuki Oichi
BACKGROUND: Ventral lesions of the upper thoracic spinal cord due to degenerative diseases are rare and often have poor operative outcomes. Anterior decompression for the lesion is difficult because of the local anatomy. This retrospective study aimed to evaluate reproducible anatomical measurements for selecting the best surgical approach for anterior decompression of ventral lesions of the upper thoracic spinal cord. METHODS: Cases of anterior decompression for ventral lesions of the upper thoracic spinal cord due to degenerative diseases at our institution during 2004-2015 were assessed...
February 8, 2019: World Neurosurgery
Sebastian Sarudis, Anna Karlsson, Dan Bibac, Jan Nyman, Anna Bäck
PURPOSE: Evaluate the performance of three commercial deformable image registration (DIR) solutions on computed tomography (CT) image-series of the thorax. METHODS: DIRs were performed on CT image-series of a thorax phantom with tumor inserts and on six 4-dimensional patient CT image-series of the thorax. The center of mass shift (CMS), dice similarity coefficient (DSC) and dose-volume-histogram (DVH) parameters were used to evaluate the accuracy. Dose calculations on deformed patient images were compared to calculations on un-deformed images for the gross tumor volume (GTV) (Dmean , D98% ), lung (V20Gy , V12Gy ), heart and spinal cord (D2% )...
January 2019: Physica Medica: PM
Ju-Hwi Kim, Seul-Kee Lee, Jong-Hwan Hong, Bong Ju Moon, Jung-Kil Lee
INTRODUCTION: A 26-year-old man presented with acute quadriparesis owing to a traffic accident. A computed tomography scan revealed a hangman fracture and locking of the left facet joint at C2-3. Magnetic resonance imaging showed a high signal change of the spinal cord on T2-weighted image and hemorrhage in the C2-3 level. An emergency closed reduction after anterior cervical discectomy and fusion were performed for spinal stability and decompression of the dural sac. Five months postoperatively, C1-2-3 posterior wiring using an iliac bone graft with Brook's method was performed due to non-union of C2-3...
February 5, 2019: World Neurosurgery
Jacquelyn J Cragg, Bobo Tong, Catherine R Jutzeler, Freda M Warner, Neil Cashman, Fred Geisler, John L K Kramer
The objective of our study was to determine whether treatment with baclofen is neurologically safe with respect to exposure during recovery from spinal cord injury. We performed a secondary longitudinal analysis of a cohort of adult patients with traumatic acute spinal cord injury. Cumulative baclofen dose was computed over the first 4 weeks following injury from concomitant medication information from a completed clinical trial. The main outcome measure was neurologic status, which was assessed over 52 weeks with "marked recovery" defined as the conversion to higher sensory and motor function...
February 6, 2019: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
João Otávio Bandeira Diniz, Pedro Henrique Bandeira Diniz, Thales Levi Azevedo Valente, Aristófanes Corrêa Silva, Anselmo Cardoso Paiva
BACKGROUND AND OBJECTIVE: The spinal cord is a very important organ that must be protected in treatments of radiotherapy (RT), considered an organ at risk (OAR). Excess rays associated with the spinal cord can cause irreversible diseases in patients who are undergoing radiotherapy. For the planning of treatments with RT, computed tomography (CT) scans are commonly used to delimit the OARs and to analyze the impact of rays in these organs. Delimiting these OARs take a lot of time from medical specialists, plus the fact that involves a large team of professionals...
March 2019: Computer Methods and Programs in Biomedicine
Yuk Law, Nikolaos Tsilimparis, Fiona Rohlffs, Vladimir Makaloski, Christian-Alexander Behrendt, Franziska Heidemann, Sabine Helena Wipper, Eike Sebastian Debus, Tilo Kölbel
OBJECTIVE: Fenestrated or branched endovascular aortic repair (FB-EVAR) usually represents the last stage in endovascular treatment of postdissection aneurysm after thoracic endograft coverage of entry tear and false lumen embolization. METHODS: The study was a retrospective analysis of all patients with postdissection thoracoabdominal aneurysm treated with FB-EVAR in a single center. Short-term outcomes included technical success, operative mortality, and morbidities...
January 28, 2019: Journal of Vascular Surgery
Tonghe Wang, Beth Bradshaw Ghavidel, Jonathan J Beitler, Xiangyang Tang, Yang Lei, Walter J Curran, Tian Liu, Xiaofeng Yang
PURPOSE: Dual-energy computed tomography (DECT) using TwinBeam CT (TBCT) is a new option for radiation oncology simulators. TBCT scanning provides virtual monoenergetic images which are attractive in treatment planning since lower energies offer better contrast for soft tissues, and higher energies reduce noise. A protocol is needed to achieve optimal performance of this feature. In this study, we investigated the TBCT scan schema with the head-and-neck radiotherapy workflow at our clinic and selected the optimal energy with best contrast-noise-ratio (CNR) in organs-at-risks (OARs) delineation for head-and-neck treatment planning...
January 28, 2019: Journal of Applied Clinical Medical Physics
Marcel W M Post, Jacqueline M P Leenders, Marga Tepper, Govert J Snoek, Luc H V van der Woude, Jacinthe J E Adriaansen
STUDY DESIGN: Cross-sectional survey OBJECTIVES: To describe computer and Internet use (other than for work or study) among people with long-standing spinal cord injury (SCI), examine associations between demographic and lesion characteristics and Internet use, and examine associations between Internet use and mental health, participation, and life satisfaction. SETTING: Community, The Netherlands METHODS: Participants were 265 individuals living with SCI for at least 10 years, who were 18-35 at the onset of SCI, aged 28-65 at the time of the study and wheelchair-user...
January 28, 2019: Spinal Cord
Yan Lin, Chunhong Li, Jian Li, Ruolan Deng, Juan Huang, Qinglian Zhang, Jiayao Lyu, Na Hao, Zhirong Zhong
BACKGROUND: Frequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes and administration routes. Albumin-based nanoparticles, which can encapsulate therapeutic drugs and release cargo in a controlled pattern, show high biocompatibility and low toxicity. The Nogo protein, expressed on the surface of oligodendrocytes, can inhibit axonal growth by binding with the axonal Nogo receptor (NgR)...
January 22, 2019: Journal of Nanobiotechnology
Jessica Ausborn, Natalia A Shevtsova, Vittorio Caggiano, Simon M Danner, Ilya A Rybak
A series of recent studies identified key structures in the mesencephalic locomotor region and the caudal brainstem of mice involved in the initiation and control of slow (exploratory) and fast (escape-type) locomotion and gait. Yet, how these brainstem centers interact with each other and with the spinal locomotor circuits is poorly understood. In a previous model (Danner et al., 2017), we suggested that commissural and long propriospinal interneurons are the main targets for brainstem inputs adjusting gait...
January 21, 2019: ELife
Laura Bonfanti, Valentina Donelli, Marco Lunian, Davide Cerasti, Francesca Cobianchi, Gianfranco Cervellin
The term SCIWORA (Spinal Cord Injury Without Radiographic Abnormality) indicates a clinically appreciable post-traumatic myelopathy in the absence of spinal column findings on radiographs and/or computed tomography (CT), but with pathologic findings at magnetic resonance imaging (MRI) in approximately two-thirds of cases. Affecting mainly children younger than 8 years, SCIWORA has been, however, also described in adult patients, but, due to the uncertainty of classification and frequent co-morbidity, the term "adult SCIWORA" has generated controversy, and some debate is still active...
January 15, 2019: Acta Bio-medica: Atenei Parmensis
Arturo Bertomeu-Motos, Santiago Ezquerro, Juan A Barios, Luis D Lledó, Sergio Domingo, Marius Nann, Suzanne Martin, Surjo R Soekadar, Nicolas Garcia-Aracil
BACKGROUND: Assistive technologies aim to increase quality of life, reduce dependence on care giver and on the long term care system. Several studies have demonstrated the effectiveness in the use of assistive technology for environment control and communication systems. The progress of brain-computer interfaces (BCI) research together with exoskeleton enable a person with motor impairment to interact with new elements in the environment. This paper aims to evaluate the environment control interface (ECI) developed under the AIDE project conditions, a multimodal interface able to analyze and extract relevant information from the environments as well as from the identification of residual abilities, behaviors, and intentions of the user...
January 16, 2019: Journal of Neuroengineering and Rehabilitation
Chi-Wen Lung, Tim D Yang, Ben-Yi Liau, Waifong Catherine Cheung, Sanjiv Jain, Yih-Kuen Jan
Pressure ulcer interventions are commonly assessed with measures of seating interface pressure, such as peak pressure gradients (PPGs). Decreases in PPG magnitudes may reduce pressure ulcer risk by decreasing tissue deformation and increasing tissue perfusion of at-risk weight-bearing tissues. Changes in PPG directions, which have previously been overlooked in the seating pressure literature, may provide a transient increase in blood flow to at-risk tissues, even if the PPG magnitude and location remain the same...
January 15, 2019: Assistive Technology: the Official Journal of RESNA
Takashi Yamauchi, Suguru Kubota, Kosei Hasegawa
We report a rare case of delayed paraplegia triggered by gastrointestinal (GI) bleeding 8 months after thoracic endovascular aortic repair (TEVAR). A 78-year-old male underwent TEVAR of a descending thoracic aortic aneurysm without a postoperative neurological deficit and was discharged. Magnetic resonance image showed spinal cord infarction from Th8 to L1, and enhanced computed tomography showed a patent Adamkiewicz artery. The ostium of the intercostal artery connected with the Adamkiewicz artery was occluded...
December 25, 2018: Annals of Vascular Diseases
Misbahuddin Khaja, Toolsie Omesh, Masooma Niazi, Danial Shaikh, Sitarama Arvind Mudunuru, Olga Alexandra Reyes, Sandeep Malik
Background: Acute myeloid leukemia (AML) is the most common leukemia in adults. According to the French-American-British (FAB) system, monocytic leukemia is classified as M5. Myeloid sarcoma further occurs in 3-5% of AML. This is defined as an extramedullary tumor of myeloid cells in the lymph nodes, soft tissues, periosteum, bone, central nervous system (CNS), spinal cord, intestine, mediastinum, prostate, uterus, or ovaries. Case Presentation: Here, we describe the case of a 29-year-old female who presented with fever, swelling of gums, neck pain, and weakness, which had persisted for 1 week...
September 2018: Case Reports in Oncology
Zied Tayeb, Juri Fedjaev, Nejla Ghaboosi, Christoph Richter, Lukas Everding, Xingwei Qu, Yingyu Wu, Gordon Cheng, Jörg Conradt
Non-invasive, electroencephalography (EEG)-based brain-computer interfaces (BCIs) on motor imagery movements translate the subject's motor intention into control signals through classifying the EEG patterns caused by different imagination tasks, e.g., hand movements. This type of BCI has been widely studied and used as an alternative mode of communication and environmental control for disabled patients, such as those suffering from a brainstem stroke or a spinal cord injury (SCI). Notwithstanding the success of traditional machine learning methods in classifying EEG signals, these methods still rely on hand-crafted features...
January 8, 2019: Sensors
Rajaie Hazboun, Amanda Muñoz, Paul R Krafft, Sheri Harder, Rosemary Vannix, Alexander Zouros, Paggie Kim, Joanne Baerg
AIMS: The aims of this study were to document the injury pattern in pediatric traumatic craniocervical dissociation (CCD) and identify features of survivors. METHODS: Pediatric traumatic CCDs, diagnosed between January 2004 and July 2016, were reviewed. Survivors and nonsurvivors were compared. Categorical and continuous variables were analyzed with Fisher exact and t tests, respectively. RESULTS: Twenty-seven children were identified; 10 died (37%)...
January 7, 2019: Pediatric Emergency Care
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