Adrian Dragu, Stefan Schnürer, Cordula Surmann-Schmitt, Klaus von der Mark, Michael Stürzl, Frank Unglaub, Maya B Wolf, Mareike Leffler, Justus P Beier, Ulrich Kneser, Raymund E Horch
The aim of this study was to analyse various gene expression profiles of muscle tissue during normoxia, ischaemia and after reperfusion in human muscle free flaps, to gain an understanding of the occurring regulatory, inflammatory and apoptotic processes on a cellular and molecular basis. Eleven Caucasian patients with soft tissue defects needing coverage with microsurgical free muscle flaps were included in this study. In all patients, the muscle samples were taken from free myocutaneous flaps. The first sample was taken before induction of ischaemia in normoxia (I), another one after ischaemia (II), and the last one was taken after reperfusion (III)...
April 2011: Journal of Cellular and Molecular Medicine