Olivera Nesic, Julieann Lee, Kathia M Johnson, Zaiming Ye, Guo-Ying Xu, Geda C Unabia, Thomas G Wood, David J McAdoo, Karin N Westlund, Claire E Hulsebosch, J Regino Perez-Polo
Central neuropathic pain (CNP) is an important problem following spinal cord injury (SCI), because it severely affects the quality of life of SCI patients. As in the patient population, the majority of rats develop significant allodynia (CNP rats) after moderate SCI. However, about 10% of SCI rats do not develop allodynia, or develop significantly less allodynia than CNP rats (non-CNP rats). To identify transcriptional changes underlying CNP development after SCI, we used Affymetrix DNA microarrays and RNAs extracted from the spinal cords of CNP and non-CNP rats...
November 2005: Journal of Neurochemistry