Azra Ajkunic, Erolcan Sayar, Martine P Roudier, Radhika A Patel, Ilsa M Coleman, Navonil De Sarkar, Brian Hanratty, Mohamed Adil, Jimmy Zhao, Samir Zaidi, Lawrence D True, Jamie M Sperger, Heather H Cheng, Evan Y Yu, Robert B Montgomery, Jessica E Hawley, Gavin Ha, Thomas Persse, Patricia Galipeau, John K Lee, Stephanie A Harmon, Eva Corey, Joshua M Lang, Charles L Sawyers, Colm Morrissey, Michael T Schweizer, Roman Gulati, Peter S Nelson, Michael C Haffner
Therapeutic approaches targeting proteins on the surface of cancer cells have emerged as an important strategy for precision oncology. To capitalize on the potential impact of drugs targeting surface proteins, detailed knowledge about the expression patterns of the target proteins in tumor tissues is required. In castration-resistant prostate cancer (CRPC), agents targeting prostate-specific membrane antigen (PSMA) have demonstrated clinical activity. However, PSMA expression is lost in a significant number of CRPC tumors...
May 17, 2024: NPJ Precision Oncology