Tobias Krogh Nielsen, Ida Birkjær Petersen, Lijuan Xu, Maria Disen Barbuti, Viktor Mebus, Anni Justh, Abdulelah Ahmed Alqarzaee, Nicolas Jacques, Cécile Oury, Vinai Thomas, Morten Kjos, Camilla Henriksen, Dorte Frees
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a leading cause of mortality worldwide. MRSA has acquired resistance to next-generation β-lactam antibiotics through the horizontal acquisition of the mecA resistance gene. Development of high resistance is, however, often associated with additional mutations in a set of chromosomal core genes, known as potentiators, which, through poorly described mechanisms, enhance resistance. The yjbH gene was recently identified as a hot spot for adaptive mutations during severe infections...
May 1, 2024: Antimicrobial Agents and Chemotherapy