Yubo Yang, Yunjin Bai, Xiaoming Wang, Yaochuan Guo, Zhihai Yu, Dechao Feng, Facai Zhang, Dengxiong Li, Ping Han
PURPOSE: To explore the role of circadian clock gene NR1D1 (REV-erbα) in bladder cancer (BC). METHODS: Firstly, the association of NR1D1 level with clinical characteristics and prognosis was investigated among patients diagnosed with BC. Secondly, CCK-8, transwell, and colony formation experiments were performed among BC cells treated with Rev-erbα agonist (SR9009), as well as lentivirus and siRNA, for which NR1D1 were overexpressed (OE) and knocked down (KD), respectively...
May 18, 2023: Urologic Oncology