Yanping Liu, Yang Jiao, Xinwei Li, Guoqiang Li, Wei Wang, Zhichao Liu, Dui Qin, Lisha Zhong, Liyu Liu, Jianwei Shuai, Zhangyong Li
Cell migration, which is primarily characterized by directional persistence, is essential for the development of normal tissues and organs, as well as for numerous pathological processes. However, there is a lack of simple and efficient tools to analyze the systematic properties of persistence based on cellular trajectory data. Here, we present a novel approach, the Entropy of Angular Distribution (EAD), which combines cellular turning dynamics and Shannon entropy to explore the statistical and time-varying properties of persistence that strongly correlate with cellular migration modes...
February 16, 2024: Biophysical Journal