Ludmila de Souza Caputo, Carolina de Lima Alves, Inês Martins Laranjeira, Diana Fonseca-Rodrigues, Ademar Alves da Silva Filho, Alberto Carlos Pires Dias, Filipa Pinto-Ribeiro, Olavo Dos Santos Pereira Junior, Ana Claudia Chagas de Paula, Akinori Cardozo Nagato, José Otávio do Amaral Corrêa
Introduction: Asthma is a condition of airflow limitation, common throughout the world, with high mortality rates, especially as it still faces some obstacles in its management. As it constitutes a public health challenge, this study aimed to investigate the effect of copaiba oil (e.g., Copaifera langsdorffii ), as a treatment resource, at doses of 50 and 100 mg/kg on certain mediators of acute lung inflammation (IL-33, GATA3, FOXP3, STAT3, and TBET) and early mechanisms of lung remodeling (degradation of elastic fiber tissues, collagen deposition, and goblet cell hyperplasia)...
2024: Frontiers in Pharmacology