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JOURNAL ARTICLE
Precy D Magtoto, Bailey L Arruda, Ronaldo L Magtoto, Juan Carlos Mora-Díaz, Rina B Opulencia, David H Baum, Jeff J Zimmerman, Luis G Giménez-Lirola
Mycoplasma hyorhinis (Mhr) and M. hyosynoviae (Mhs) are commensal organisms of the upper respiratory tract and tonsils but may also cause arthritis in pigs. In this study, 8-week-old cesarean-derived colostrum-deprived (CDCD) pigs (n = 30; 3 groups, 10 pigs per group, 2 pigs per pen) were inoculated with Mhr, Mhs, or mock-inoculated with culture medium and then pen-based oral fluids were collected at different time points over the 56 days of the experimental study. Oral fluids tested by Mhr and Mhs quantitative real-time PCRs revealed Mhr DNA between day post inoculation (DPI) 5-52 and Mhs DNA between DPI 5-15...
January 24, 2024: Veterinary Microbiology
#62
JOURNAL ARTICLE
Merve Iseri Nepesov, Omer Kilic, Enes Sali, Edanur Yesil, Asuman Akar, Ayse Kaman, Ozge Metin Akcan, Merve Kilic Cil, Canan Ozlu, Sibel Lacinel Gurlevik, Emel Ulusoy, Benhur Sirvan Cetin, Narin Akici, Deniz Cakir, Fatma Deniz Uslu Aygun, Cafer Ozgur Hancerli, Ayse Tekin Yilmaz, Gulsum Alkan, Hatice Uygun, Ibrahim Hakan Bucak, Burcu Bursal, Taylan Celik, Murat Sutcu, Fatma Nur Oz, Zeynep Gokce Gayretli Aydin, Adem Karbuz, Hacer Akturk, Eda Kepenekli, Melike Emiroglu, Selim Oncel, Cagatay Nuhoglu, Ismail Hakki Korucu, Mustafa Incesu, Ahmet Kaya, Hasan Bombaci, Meltem Dinleyici, Kursat Bora Carman, Murat Duman, Ozden Turel, Dilek Yilmaz, Derya Alabaz, Nursen Belet, Gonul Tanir, Mehmet Turgut, Solmaz Celebi, Necdet Kuyucu, Emin Sami Arisoy, Gul Durmaz, Mucahit Kaya, Ates Kara, Ener Cagri Dinleyici
OBJECTIVES: Septic arthritis (SA) is a serious bacterial infection that must be treated efficiently and timely. The large number of culture-negative cases makes local epidemiological data important. Accordingly, this study aimed to evaluate the etiology, clinical characteristics, and therapeutic approach of SA in children in Turkiye, emphasizing the role of real-time polymerase chain reaction (PCR) techniques in the diagnosis. METHODS: In this multi-center, prospective study, children hospitalized due to SA between February 2018 and July 2020 in 23 hospitals in 14 cities in Turkiye were included...
January 22, 2024: Children
#63
JOURNAL ARTICLE
Ninette Natascha Bornemann, Leonie Mayer, Sonia Lacouture, Marcelo Gottschalk, Christoph Georg Baums, Katrin Strutzberg-Minder
Locomotor and central nervous system disorders occur during pig rearing, but there is no systematic recording of the different causative agents in Germany. Joint and meningeal swabs, kidneys, lungs, and eight different lymph nodes per pig were cultured, and isolated pathogens were identified using polymerase chain reactions (PCRs). The cps and pathotype of Streptococcus suis ( S. suis ) isolates were determined using multiplex-PCR. S. suis was the most important pathogen in the infected joints (70.8%) and meningeal swabs (85...
January 2, 2024: Veterinary Sciences
#64
Nathaniel G Rogers
Septic arthritis is uncommon in pediatric patients, who are less likely to have major risk factors such as underlying joint disease or prosthetic joints. It only rarely affects the elbow and is usually caused by Gram-positive cocci, with Staphylococcus aureus being the most common bacterial organism. We present the case of a 15-year-old previously healthy female who experienced new-onset monoarticular nontraumatic elbow pain and was found to have a synovial effusion growing from Moraxella catarrhalis . The atypical clinical presentation, coupled with the growth of an unusual organism, raised concern for an underlying immunocompromising or inflammatory joint disorder...
December 2023: Curēus
#65
JOURNAL ARTICLE
Xieyue Xiao, Henry H Le, Min-Ting Lee, Daniel Lamm, Elizabeth L Johnson, Ilana L Brito
Sphingolipids are important signaling molecules for maintaining metabolic and immune homeostasis in the host. These lipids are also produced by gut commensals, most notably by Bacteroides species. Despite the global prevalence of Prevotella copri in gut microbiomes of individuals, little is known about the types of sphingolipids they produce and whether they are similar in composition and structure to those produced by Bacteroides . Given the varied associations of P. copri with diverse sphingolipid-related health outcomes, such as rheumatoid arthritis and glucose intolerance, it is important to first characterize the specific sphingolipids produced by individual strains of P...
January 18, 2024: MBio
#66
JOURNAL ARTICLE
Danielle Cristina Fonseca, Ilanna Marques Gomes da Rocha, Bianca Depieri Balmant, Leticia Callado, Ana Paula Aguiar Prudêncio, Juliana Tepedino Martins Alves, Raquel Susana Torrinhas, Gabriel da Rocha Fernandes, Dan Linetzky Waitzberg
UNLABELLED: Gut microbiota has been implicated in various clinical conditions, yet the substantial heterogeneity in gut microbiota research results necessitates a more sophisticated approach than merely identifying statistically different microbial taxa between healthy and unhealthy individuals. Our study seeks to not only select microbial taxa but also explore their synergy with phenotypic host variables to develop novel predictive models for specific clinical conditions. DESIGN: We assessed 50 healthy and 152 unhealthy individuals for phenotypic variables (PV) and gut microbiota (GM) composition by 16S rRNA gene sequencing...
2024: Gut Microbes
#67
JOURNAL ARTICLE
Alex B Walinga, Stein J Janssen, Arthur J Kievit, Corianne A J M de Borgie, Gino M M J Kerkhoffs
PURPOSE: The literature presents a wide range of success rates for a single surgical intervention of bacterial-septic-arthritis, and there is a lack of clear criteria for identifying treatment failure and making decisions about reintervention. This Delphi study aims to establish a consensus among an international panel of experts regarding the definition of treatment failure and the criteria for reintervention in case of bacterial arthritis. METHODS: The conducting and reporting Delphi studies (CREDES) criteria were used...
January 5, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
#68
Victoria Overbeck, Bradford P Taylor, Jacquelyn Turcinovic, Xueting Qiu, Beau Schaeffer, Scott Seitz, Scott R Curry, William P Hanage, John H Connor, Krutika Kuppalli
BACKGROUND: Immunocompromised patients receiving B-cell-depleting therapies are at increased risk of persistent SARS-CoV-2 infection, with many experiencing fatal outcomes. We report a successful outcome in a patient with rheumatoid arthritis (RA) on rituximab diagnosed with COVID-19 in July 2020 with persistent infection for over 245 days. RESULTS: The patient received numerous treatment courses for persistent COVID-19 infection, including remdesivir, baricitinib, immunoglobulin and high doses of corticosteroids followed by a prolonged taper due to persistent respiratory symptoms and cryptogenic organizing pneumonia...
January 15, 2024: Heliyon
#69
JOURNAL ARTICLE
Christa D Jackson, Mohammad Badran, David Gozal, Charles R Brown, Abdelnaby Khalyfa
STUDY OBJECTIVES: Lyme arthritis is a common late-stage complication of infection by Borrelia burgdorferi, the agent of Lyme disease. Patients with Lyme arthritis report increased levels of sleep disturbance associated with pain. Using a mouse model of experimental Lyme arthritis, we investigated the effect of disrupted sleep on the development and resolution of joint inflammation. METHODS: Lyme arthritis-susceptible C3H/HeJ mice (n = 10/group) were infected with B...
January 11, 2024: Sleep Medicine
#70
JOURNAL ARTICLE
James C McSorley, Darshini Reyes, Ivan Tonna, Vhairi Bateman
PURPOSE: Dalbavancin, approved in 2014 for Gram-positive acute bacterial skin and skin structure infections (ABSSSI), has pharmacokinetics enabling treatment with one or two doses. Dalbavancin might be useful in outpatient parenteral antibiotic therapy (OPAT) of deep-seated infections, otherwise requiring inpatient admission. We documented our experience with pragmatic dalbavancin use to assess its effectiveness for varied indications, on- and off-label, as primary or sequential consolidation therapy...
January 2, 2024: Infection
#71
JOURNAL ARTICLE
Rituparna Ghosh, Biswadev Bishayi
In vivo studies identifying a role of TLR2 in septic arthritis models are lacking. TNF-α played as the most important proinflammatory cytokine, and connected directly to the pathogenesis of bacterial arthritis. IL-1β is another central mediator cytokine in arthritis. It is therefore reasonable to question the role of neutralization of endogenous TNF-α and IL-1β along with TLR2 and associated downstream signaling as crucial mediators in the S. aureus -induced inflammatory arthritis. In reaction to an injury or a pathogen encounter, innate immune cells serve as the initial line of defense...
December 29, 2023: Microbial Pathogenesis
#72
REVIEW
Yuti Godha, Sunil Kumar, Anil Wanjari
Rheumatoid arthritis is an autoimmune condition that damages and inflames the joints. It causes severe disability and lowers the quality of life. While the precise cause of rheumatoid arthritis is still unknown, mounting evidence suggests that the gut microbiota, a diverse colony of bacteria that inhabits the gastrointestinal tract, may play a vital role in the progression and management of this debilitating condition. By evaluating relationships, probable processes, and therapeutic ramifications, this narrative review intends to examine the complex relationship between intestinal microbiota and rheumatoid arthritis...
November 2023: Curēus
#73
REVIEW
Riccardo Bixio, Davide Bertelle, Eugenia Bertoldo, Andrea Morciano, Maurizio Rossini
A growing amount of evidence suggests that gut microbiota plays an important role in human health, including a possible role in the pathogenesis of rheumatic and musculoskeletal diseases (RMD). We analysed the current evidence about the role of microbiota in rheumatoid arthritis (RA), spondyloarthritis (SpA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). In RA, we found a general consensus regarding a reduction of diversity and a specific bacterial signature, with consistent changes according to the different ethnic and geographical areas...
December 23, 2023: Internal and Emergency Medicine
#74
Razvan Silviu Cismasiu, Rares-Mircea Birlutiu, Liliana Lucia Preoțescu
The Bacillus and Paenibacillus genera are diverse soil-related bacterial pathogens. In this case report, we describe, to our knowledge, the first report of septic arthritis in a native hip joint in an immunocompetent adult patient caused by Bacillus pumilus and Paenibacillus barengoltzii . We describe the case of a 39-year-old Caucasian male patient who sought medical advice for chronic pain on the mobilization of the right hip, decreased range of motion, and physical asthenia. The patient underwent a surgical intervention (core decompression) for a right osteonecrosis of the femoral head, with a slightly favorable postoperative evolution after surgery for one month...
December 18, 2023: Pharmaceuticals
#75
REVIEW
Yésica Carmona Rendón, Hernán Santiago Garzón, Bruno Bueno-Silva, Roger M Arce, Lina Janeth Suárez
INTRODUCTION: Cannabinoids are a well-documented treatment modality for various immune and inflammatory diseases, including asthma, chronic obstructive pulmonary disease, Crohn's disease, arthritis, multiple sclerosis, and a range of neurodegenerative conditions. However, limited information is available regarding the therapeutic potential of cannabinoids in treating periodontal disease. OBJECTIVE: The objective of this study is to analyze the current evidence on the antibacterial and immunomodulatory effects of cannabis and its role in the healing and regeneration processes within periodontal tissues...
November 30, 2023: Antibiotics
#76
JOURNAL ARTICLE
Irene Nocera, Micaela Sgorbini, Valentina Meucci, Luis A Gracia-Calvo, Heidi Tapio, Marcello Camisi, Giulia Sala, Simonetta Citi
Early diagnosis of joint diseases is fundamental for prompt and appropriate management, particularly in septic arthritis. Procalcitonin (PCT) and protein carbonylated content (PCC) have been investigated in both human and veterinary medicine. An increase in PCT has been shown in infectious bacterial diseases, while higher levels of PCC have been shown in inflammatory pathologies characterized by oxidative damage. This study evaluated PCT and PCC in plasma and synovial fluid (SF), in healthy and pathological equine joints, affected by different types of arthropathy...
December 21, 2023: Veterinary Research Communications
#77
JOURNAL ARTICLE
Joseph Baxter, Aubri Waters
Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency. It is characterized by hypogammaglobulinemia and can present with a broad range of symptoms including recurrent bacterial infections, autoimmunity, and malignancy. Rarely, it has been implicated with peripheral neuropathy. We present a case of CVID with peripheral neuropathy and a pathogenic heterozygous variant of IL-7 receptor gene. The patient is a 38-year-old female with a history of recurrent infections since childhood including pneumonia and sinus infections status post tonsillectomy and sinus surgery...
December 21, 2023: Military Medicine
#78
Leyla Ozbek, Jonathon Kyriakides, Ajay Asokan
Septic arthritis is a serious condition resulting in rapid destruction of articular cartilage and potential sepsis. Bacterial invasion of a joint occurs most commonly as a result of haematogenous spread from a distant infection. However, an otogenic source of this transient bacteraemia and resultant septic arthritis has not yet been reported in the literature. We report a case of acute septic arthritis of the knee with Streptococcus pyogenes , secondary to acute otitis media of the ear.
December 2023: Journal of Surgical Case Reports
#79
JOURNAL ARTICLE
Brenda J Seymour, Brandon Trent, Brendan E Allen, Adam J Berlinberg, Jimmy Tangchittsumran, Widian K Jubair, Meagan E Chriswell, Sucai Liu, Alfredo Ornelas, Andrew Stahly, Erica E Alexeev, Alexander S Dowdell, Sunny L Sneed, Sabrina Fechtner, Jennifer M Kofonow, Charles E Robertson, Stephanie M Dillon, Cara C Wilson, Robert M Anthony, Daniel N Frank, Sean P Colgan, Kristine A Kuhn
Altered tryptophan catabolism has been identified in inflammatory diseases like rheumatoid arthritis (RA) and spondyloarthritis (SpA), but the causal mechanisms linking tryptophan metabolites to disease are unknown. Using the collagen-induced arthritis (CIA) model we identified alterations in tryptophan metabolism, and specifically indole, that correlated with disease. We demonstrated that both bacteria and dietary tryptophan were required for disease, and indole supplementation was sufficient to induce disease in their absence...
December 19, 2023: Journal of Clinical Investigation
#80
JOURNAL ARTICLE
Ulrikka Nygaard, Ulla Birgitte Hartling, Charlotte Munkstrup, Allan Bybeck Nielsen, Kia Hee Schultz Dungu, Lisbeth Samsø Schmidt, Jonathan Glenthøj, Astrid Thaarup Matthesen, Maren Johanne Heilskov Rytter, Mette Holm
BACKGROUND: A historic increase in paediatric invasive group A streptococcal (iGAS) infections was reported globally in 2022. iGAS infections can lead to severe manifestations (eg, pleural empyema, necrotising fasciitis, toxic shock syndrome, osteomyelitis, septic arthritis, and meningitis). We aimed to compare the incidence and severity of iGAS infections overall, for distinct clinical phenotypes, and for GAS emm variants in Denmark in 2022-23 with reference to the previous six seasons (ie, 2016-17, 2017-18, 2018-19, 2019-20, 2020-21, and 2021-22)...
December 13, 2023: Lancet Child & Adolescent Health
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