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Gallium 68

Laura Rozenblum, Fatima-Zohra Mokrane, Randy Yeh, Mathieu Sinigaglia, Florent Besson, Romain-David Seban, Cecile N Chougnet, Paul Revel-Mouroz, Binsheng Zhao, Philippe Otal, Lawrence H Schwartz, Laurent Dercle
Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms that secrete peptides and neuro-amines. pNETs can be sporadic or hereditary, syndromic or non-syndromic with different clinical presentations and prognoses. The role of medical imaging includes locating the tumor, assessing its extent, and evaluating the feasibility of curative surgery or cytoreduction. Pancreatic NETs have very distinctive phenotypes on CT, MRI, and PET. PET have been demonstrated to be very sensitive to detect either well-differentiated pNETs using 68 Gallium somatostatin receptor (SSTR) radiotracers, or more aggressive undifferentiated pNETS using 18 F-FDG...
April 12, 2019: Abdominal Radiology
Maike E Lindemann, Nika Guberina, Axel Wetter, Wolfgang Fendler, Bjoern Jakoby, Harald H Quick
Purpose: A limitation of using 68-gallium-labelled prostate-specific membrane antigen (68-Ga-PSMA) for detection and staging of prostate cancer is a frequently observed halo artifact around the urinary bladder caused by inaccurate scatter correction (SC) of positron emission tomography (PET) data. The aim of this study is to investigate the impact of un-renormalized absolute SC on 68-Ga-PSMA PET quantification in PET/magnetic resonance (MR) hybrid imaging of the prostate in 100 patients. Methods: The PET data of 100 patients were reconstructed twice using standard SC and improved un-renormalized SC...
April 12, 2019: Journal of Nuclear Medicine
Crishan Haran, Rhiannon McBean, Rex Parsons, David Wong
INTRODUCTION: In the last 5 years, there has been a significant focus on the use of positron emission tomography (PET) for primary and secondary staging of prostate cancer. In this study, we aim to describe the trends of use between Gallium-68 prostate-specific membrane antigen ligand (Ga-68 PSMA) PET/computed tomography (PSMA PET/CT) and nuclear medicine bone scan (NMBS) for prostate cancer staging in the first institution in Australia to offer both modalities. METHODS: We evaluated trends in prostate cancer staging/restaging imaging modalities at our facility between the time period January 2013-April 2018...
April 11, 2019: Journal of Medical Imaging and Radiation Oncology
Mohammad Abd Alkhalik Basha, Maged Abdel Galil Hamed, Omar Hussein, Tarek El-Diasty, Yasser Ibrahim Abdelkhalek, Yehia Omar Hussein, Ahmed Fathy Alasamer, Heba A E Mohamed, Dalia Salah El Deen, Engy Fathy Tantawy, Maha Ibrahim Metwally, Mohamed M A Zaitoun, Sameh Abdelaziz Aly, Jehan Ibrahim Altohamy, Abd El Motaleb Mohamed, Amira Hamed Mohamed Afifi, Ola Harb
PURPOSE: To determine the diagnostic sensitivity and interobserver agreement of Gallium 68-prostate-specific membrane antigen positron emission tomography/computed tomography (68 Ga-PSMA-11 PET/CT) imaging for diagnosis and staging of patients with newly diagnosed prostate cancer (PC). MATERIALS AND METHODS: One hundred and seventy-three men (mean age, 68 ± 7.7 years; range 46-84 years) with newly diagnosed, untreated PC were enrolled in this prospective study between January 2017 and August 2018...
April 8, 2019: Abdominal Radiology
Yi Liu, Xiang Li, Yongheng Gao, Fei Kang, Xiaowei Ma, Weidong Yang, Jing Wang, Wenhui Ma
Peptides containing the asparagine-glycine-arginine (NGR) motif can target the tumor neovascular biomarker CD13/aminopeptidase N receptor. D-K6L9 is a tumor-selective anti-cancer peptide. To improve the capacity of NGR peptides to target tumors, we joined the NGR and D-K6L9 peptides to form NKL. Next, we linked 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to NKL and labeled it with gallium 68 (68Ga, t1/2 = 67.7 min) to form 68Ga-DOTA-NKL. This novel probe was characterized in vitro. 68Ga-DOTA-NKL was stable in phosphate buffered saline at room temperature and in human serum at 37°C...
March 29, 2019: Current Pharmaceutical Design
Lauren Boreta, Adam J Gadzinski, Susan Y Wu, Melody Xu, Kirsten Greene, Kathryn Quanstrom, Hao G Nguyen, Peter R Carroll, Thomas A Hope, Felix Y Feng
OBJECTIVE: To identify locations of recurrence after radical prostatectomy (RP) with PSA <2 by Gallium-68 Prostate Specific Membrane Antigen (PSMA)-11 PET imaging, and to determine whether standard nodal radiation fields would cover the location of prostate cancer recurrence. MATERIALS/METHODS: We performed a retrospective review of patients with PSMA-PET imaging for biochemical recurrence following RP with PSA ≤ 2.0 ng/ml and assessed if the recurrent disease was within standard radiation target volumes...
March 27, 2019: Urology
Carlos Velasco, Adriana Mota-Cobián, Rubén A Mota, Juan Pellico, Fernando Herranz, Carlos Galán-Arriola, Borja Ibáñez, Jesús Ruiz-Cabello, Jesús Mateo, Samuel España
BACKGROUND: Here we evaluated the feasibility of PET with Gallium-68 (68 Ga)-labeled DOTA for non-invasive assessment of myocardial blood flow (MBF) and extracellular volume fraction (ECV) in a pig model of myocardial infarction. We also aimed to validate MBF measurements using microspheres as a gold standard in healthy pigs. METHODS: 8 healthy pigs underwent three sequential 68 Ga-DOTA-PET/CT scans at rest and during pharmacological stress with simultaneous injection of fluorescent microspheres to validate MBF measurements...
March 29, 2019: Journal of Nuclear Cardiology
Michael McCarthy, Roslyn Francis, Colin Tang, Joanne Watts, Andrew Campbell
AIM: This study is to assess the utility of68 Gallium PSMA HBED-CC PET/CT (PSMA-HBED), compared to standard imaging, in the detection of recurrent prostate carcinoma in patients with biochemical relapse, to determine the prevalence of oligometastatic disease recurrence and its distribution. METHOD: This is a prospective, multicentre clinical trial of PSMA-HBED PET/CT imaging in patients with early biochemical relapse of prostate carcinoma (PCa) (median PSA 2.55ng/ml) following definitive prostatectomy (152 patients) or radiotherapy (86 patients) with either no lesions or oligometastatic disease on abdominopelvic CT (CT) and bone scan (BS)...
March 16, 2019: International Journal of Radiation Oncology, Biology, Physics
Ambreen Khawar, Elisabeth Eppard, Frank Roesch, Hojjat Ahmadzadehfar, Stefan Kürpig, Michael Meisenheimer, Florian C Gaertner, Markus Essler, Ralph A Bundschuh
OBJECTIVE: Pre-clinical studies with gallium-68 zoledronate ([68 Ga]Ga-DOTAZOL ) have proposed it to be a potent bisphosphonate for PET/CT diagnosis of bone diseases and diagnostic counterpart to [177 Lu]Lu-DOTAZOL and [225 Ac]Ac-DOTAZOL . This study aims to be the first human biodistribution and dosimetric analysis of [68 Ga]Ga-DOTAZOL . METHODS: Five metastatic skeletal disease patients (mean age: 72 years, M: F; 4:1) were injected with 150-190 MBq (4.05-5.14 mCi) of [68 Ga]Ga-DOTAZOL i...
March 15, 2019: Annals of Nuclear Medicine
Sébastien Bergeret, Judith Charbit, Catherine Ansquer, Géraldine Bera, Philippe Chanson, Charlotte Lussey-Lepoutre
Nuclear medicine has been implicated in the diagnosis and treatment of endocrine disorders for several decades. With recent development of PET tracers, functional imaging now plays a major role in endocrine tumors enabling with high performance to their localization, characterization, and staging. Besides 18 F-FDG, which may be used in the management and follow-up of endocrine tumors, new tracers have emerged, such as 18 F-DOPA for neuroendocrine tumors (NETs) (medullary thyroid carcinoma, pheochromocytomas and paragangliomas and well-differentiated NETs originating from the midgut) and 18 F-Choline in the field of primary hyperparathyroidism...
March 14, 2019: Endocrine
Jussi Mäkilä, Anu Kiviniemi, Tiina Saanijoki, Heidi Liljenbäck, Meeri Kakela, Satish Jadhav, Paivi Poijarvi-Virta, Harri Lonnberg, Tiina Laitala-Leinonen, Pasi Virta, Anne Roivainen
MicroRNAs (miRNAs) are endogenous, small, non-coding ribonucleic acids (RNAs) that bind to the 3' untranslated regions of messenger RNAs (mRNAs) and induce translational repression or mRNA degradation. Although numerous studies have reported that miRNAs are of potential use for disease diagnostics and gene therapy, little is known about their fates in vivo. This study elucidated the whole-body distributions and kinetics of intravenously administered miRNA-targeting molecules in vivo by positron emission tomography (PET) imaging...
March 13, 2019: Molecular Pharmaceutics
Cinzia Imberti, Yu-Lin Chen, Calum A Foley, Michelle T Ma, Brett M Paterson, Yifu Wang, Jennifer D Young, Robert C Hider, Philip J Blower
The prototype tris(1,6-dimethyl-3-hydroxypyridin-4-one) chelator for gallium-68, THPMe, has shown great promise for rapid and efficient kit-based 68Ga labelling of PET radiopharmaceuticals. Peptide derivatives of THPMe have been used to image expression of their target receptors in vivo in preclinical and clinical studies. Herein we describe new synthetic routes to the THP platform including replacing the 1,6-dimethyl-3-hydroxypyridin-4-one N1-CH3 group of THPMe with O (tris(6-methyl-3-hydroxypyran-4-one, THPO) and N1-H (tris(6-methyl-3-hydroxypyridin-4-one), THPH) groups...
March 12, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Burcak Yilmaz, Serap Nisli, Nurhan Ergul, Riza Umar Gursu, Ozgur Acikgoz, Tevfik Fikret Cermik
Metastatic castration-resistant prostate cancer (mCRPC) patients have been started to treat with prostate-specific membrane antigen (PSMA) targeted radioligand therapy (PRLT), especially with Lu-177 PSMA-617 in recent years. But, side effects of PRLT against salivary glands, limits the treatment safety. Current study aims to show the effect of external cooling with icepacks on Lu-177 PSMA-617 uptake in parotid glands (PGs). Methods: Nineteen patients (Mean age 72.9 years) who had pre-treatment Gallium-68 (Ga-68) PSMA-11 Positron emission tomography/Computed tomography (PET/CT) with mCRPC referred for the first time for Lu-177 PSMA-617 treatment were included...
March 8, 2019: Journal of Nuclear Medicine
Ozgul Ekmekcioglu, Martijn Busstra, Natalie Desiree Klass, Fred Verzijlbergen
Background: Gallium-68 and Fluor-18 labeled prostate specific membrane antigen (PSMA) molecules have created new opportunities for the unmet diagnostic needs in prostate cancer. The purpose of this study is to give an overview of the studies that have examined the role of PSMA PET scan in treatment planning in prostate cancer patients with biochemical recurrence. Methods: Medline, Embase, Web of Science, Google Scholar, and Cochrane Central were searched for relevant articles. After excluding the articles that did not fulfill the required criteria, 12 publications that reported the impact of PSMA-PET on the treatment plan in prostate cancer patients with biochemical recurrence (BCR) were included in the review...
March 8, 2019: Journal of Nuclear Medicine
Nikoletta K Pianou, Petros Z Stavrou, Evangelia Vlontzou, Phivi Rondogianni, Demetrios N Exarhos, Ioannis E Datseris
Prostate cancer (PCa) is the most common solid cancer affecting men worldwide. Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment. Bone metastases (BM) are present in advanced stages of the disease. Imaging of BM is important not only for localization and characterization, but also to evaluate their size and number, as well as to follow-up the disease during and after therapy. Bone metastases formation is triggered by cancer initiating cells in the bone marrow and is facilitated by the release of several growth factors...
March 5, 2019: Hellenic Journal of Nuclear Medicine
Louise McEwan, Rhiannon McBean, John Yaxley, David Wong
INTRODUCTION: There is increasing scientific evidence that whole-body Gallium-68 prostate-specific membrane antigen (68 Ga-PSMA) positron emission tomography/computed tomography (PET/CT) improves the sensitivity of prostate cancer detection above standard staging radiology. Diagnostic IV-contrasted CT scanning offers high-quality recognition and delineation of organs and structures with a high sensitivity and specificity for diagnoses of many non-prostate pathologies. At our institution, imaging for prostate cancer staging and restaging involves a 68 Ga-PSMA PET/CT scan combined with a diagnostic IV-contrasted CT scan of the head, neck, chest, abdomen and pelvis...
March 6, 2019: Journal of Medical Imaging and Radiation Oncology
Piriya Kaeopookum, Dominik Summer, Joachim Pfister, Thomas Orasch, Beatrix E Lechner, Milos Petrik, Zbynek Novy, Barbara Matuszczak, Christine Rangger, Hubertus Haas, Clemens Decristoforo
PURPOSE: Aspergillus fumigatus produces the siderophore triacetylfusarinine C (TAFC) for iron acquisition which is essential for its virulence. Therefore, TAFC is a specific marker for invasive aspergillosis. We have shown previously that positron emission tomography (PET) imaging with [68 Ga]TAFC exhibited excellent targeting properties in an A. fumigatus rat infection model. In this study, we aimed to prepare TAFC analogs modifying fusarinine C (FSC) by acylation with different carbon chain lengths as well as with charged substituents and investigated the influence of introduced substituents on preservation of TAFC characteristics in vitro and in vivo...
March 5, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Paulo S G Cremonez, Janaina F Matsumoto, Avacir C Andrello, Samuel Roggia, Daniela O Pinheiro, Pedro M O J Neves
Euschistus heros is an important pest in many crops in Brazil, and different control strategies, mainly involving chemicals, have been evaluated; however, the side effects of these chemicals on the balance of inorganic element levels in the hemolymph are unknown. Thus, the aim of this work was to determine the concentration of inorganic elements (focusing on macro-elements) in the hemolymph of female and male E. heros adults, after applying pyriproxyfen at a sublethal concentration (LC30  = 6.68 mL L-1 diluted in distilled water) to 4th instar nymphs, which were kept in controlled conditions...
February 27, 2019: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
Stephanie Kim, William P Dillon, Thomas A Hope, Ivan H El-Sayed, Annemieke van Zante, Karin Wu, Umesh Masharani
Ectopic thyroid-secreting hormone (TSH)-secreting pituitary adenomas are rare, with only nine cases reported in the literature. We describe a case of an ectopic TSH-secreting pituitary adenoma located in the nasopharynx in a patient initially presenting with signs and symptoms of hyperthyroidism that persisted despite treatment with anti-thyroid medications. Magnetic resonance imaging (MRI) of the pituitary gland was normal, though subsequent review by neuroradiology revealed a nodule attached to the posterior septum in the nasopharynx that was, in retrospect, seen on several other MR scans...
February 21, 2019: World Neurosurgery
Jasmine Shell, Amit Tirosh, Corina Millo, Samira M Sadowski, Yasmine Assadipour, Patience Green, Dhaval Patel, Naris Nilubol, Electron Kebebew
PURPOSE: Patients with von Hippel-Lindau (VHL) disease may develop various tumors, including neuroendocrine tumors of the pancreas (PNETs) and adrenal, central nervous system and retinal hemangioblastomas, kidney tumors and more. 68 Ga-DOTATATE positron emission tomography (PET)/computerized tomography (CT) has been shown to be highly accurate for tumors with cells expressing somatostatin receptors. We aimed to assess the performance of 68 Ga-DOTATATE PET/CT in patients with VHL disease...
March 2019: European Journal of Radiology
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