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(Cutaneous metastasis) melanoma

Danique M S Berger, Martinus M van Veen, Max F Madu, Alexander C J van Akkooi, Wouter V Vogel, Alfons J M Balm, Willem M C Klop
BACKGROUND: Parotidectomy in melanoma of the coronal scalp and face with clinically involved cervical lymph node metastasis is based on predicted cervical lymphatic drainage described by O'Brien. METHODS: In total, 40 parotidectomies with en bloc therapeutic neck dissection were retrospectively analyzed. RESULTS: Lymphatic spread of melanoma to the parotid lymph nodes was observed in 10 of 40 specimens (25%). Eight of the 10 parotid-positive patients developed a recurrence vs 17 of the 30 parotid-negative patients (P = 0...
February 14, 2019: Head & Neck
Junji Kato, Tokimasa Hida, Masanori Someya, Sayuri Sato, Masahide Sawada, Kohei Horimoto, Mao Fujioka, Tomoyuki Minowa, Yoshiyuki Matsui, Takaaki Tsuchiya, Mio Kitagawa, Kensei Nakata, Koh-Ichi Sakata, Toshihiko Torigoe, Hisashi Uhara
Some studies showed that clinical response to immune check point inhibitors is lower in acral and mucosal melanoma than in cutaneous melanoma. Although the synergistic effect of radiotherapy (RT) and ipilimumab has been reported in patients with brain metastasis, the efficacy of combined RT and anti-programmed death 1 (PD-1) therapy for acral and mucosal melanoma is unclear. The present study aimed to evaluate the efficacy of combined RT and anti-PD-1 therapy for acral and mucosal melanoma. We retrospectively analyzed patients with acral or mucosal melanoma who were treated with anti-PD-1 and RT at Sapporo Medical University Hospital...
February 13, 2019: Journal of Dermatology
Maximilian Gassenmaier, Ulrike Keim, Ulrike Leiter, Thomas K Eigentler, Martin Röcken, Anja Gesierich, Rose K C Moritz, Lucie Heinzerling, Thomas Tüting, Uwe Wollina, Claus Garbe
BACKGROUND: Melanoma incidence rates rise as people age but the impact of aging on distant metastasis is unclear. OBJECTIVE: To investigate how timing, pattern and extent of distant metastasis is influenced by age. METHODS: Analysis of a single-center cohort of 1.457 patients of the German Central Malignant Melanoma Registry with prospectively documented follow-up. Findings were compared with those of 1.682 patients from five different institutions...
January 28, 2019: Journal of the American Academy of Dermatology
Eric Fountain, Roland L Bassett, Suzanne Cain, Liberty Posada, Dan S Gombos, Patrick Hwu, Agop Bedikian, Sapna P Patel
Uveal melanoma is a common intraocular malignant tumor that is uniformly fatal once metastatic. No effective adjuvant therapy currently exists to reduce the risk of distant metastasis after definitive treatment of the primary lesion. Immunotherapy has been used effectively in the adjuvant setting in locally advanced cutaneous melanoma. We performed a Phase I/II clinical trial of adjuvant ipilimumab in high-risk primary uveal melanoma with distant metastasis-free survival (DMFS) as the primary objective. A total of 10 patients with genomically high-risk disease were treated: three at a dose of 3 mg/kg and seven at 10 mg/kg...
January 29, 2019: Cancers
Brian R Gastman, Jonathan S Zager, Jane L Messina, Robert W Cook, Kyle R Covington, Brooke Middlebrook, Pedram Gerami, Jeffrey D Wayne, Sancy Leachman, John T Vetto
BACKGROUND: We report the performance of a gene expression profile test to classify the recurrence risk of cutaneous melanoma tumors of the head and neck as low-risk Class 1 or high-risk Class 2. METHODS: Of note, 157 primary head and neck cutaneous melanoma tumors were identified. Survival analyses were performed using Kaplan-Meier and Cox methods. RESULTS: Gene expression profile class and node status stratified tumors into significantly different 5-year survival groups by Kaplan-Meier method (P < ...
January 29, 2019: Head & Neck
Sasmita Panda, Sashibhusan Dash, Kusumbati Besra, Sagarika Samantaray, Pramod Chandra Pathy, Niranjan Rout
BACKGROUND: : Malignant melanoma is a tumor of melanocytic origin. Although uncommon in India as compared with the west, its prevalence is increasing. OBJECTIVES: To document the pattern of clinicopathological features of malignant melanoma cases attending in a regional cancer center in eastern India. MATERIAL AND METHODS: The present study was a retrospective study of 182 cases diagnosed histopathologically as malignant melanoma during 2011-2016...
July 2018: Indian Journal of Cancer
Nima Milani-Nejad, Chase Scarbrough, Shakuntala H Mauzo, Sara B Peters, Mark A Bechtel, David Carr
Melanoma is a highly aggressive cutaneous malignancy with considerable risk for metastasis. These malignant tumors are typically pigmented given that they arise from melanocytes capable of producing melanin. Amelanotic melanomas are a rare variant and there is often a delay in diagnosis owing to lack of pigmentation. Although there are various presentations of amelanotic melanoma, a solitary polypoid nodule is unusual and warrants further reporting. Herein, we present a patient with a 3-year history of a tender firm, skin-to-pink colored polypoid nodule...
August 15, 2018: Dermatology Online Journal
Cristian Navarrete-Dechent, Miguel Cordova, Michael A Postow, Melissa Pulitzer, Cecilia Lezcano, Allan C Halpern, Anthony M Rossi
Importance: Melanoma incidence and the use of systemic treatments for it are rising. Current treatment monitoring uses clinical examination and radiologic examinations; however, cutaneous involvement and cutaneous metastasis may not be well visualized. Reflectance confocal microscopy (RCM) is a US Food and Drug Administration-approved, noninvasive technology that enables visualization of the skin with quasihistological resolution. Objective: To evaluate the feasibility of using RCM to monitor advanced melanomas treated with immunotherapy...
January 9, 2019: JAMA Dermatology
Renata-Lucena Markman, Giuliano-Augusto-Belizario Rosa, Leonardo Cardili, Luciana-Estevam Simonato, Thais-Bianca Brandão, Ana-Carolina-Prado Ribeiro
Introduction: Malignant metastases to the oral cavity are rare and metastatic melanomas of the tongue are considered exceptionally uncommon, with less than 10 cases published in the English literature so far. Case reports: Two female patients in the 7th decade of life presented to our dental service with nodules in the tongue. Both patients had multiple metastases at the time of oral diagnosis and primary melanoma originated on the skin. An intra-oral incisional biopsy was performed under local anesthesia and the histopathologic analysis was characterized by the proliferation of atypical epithelioid cells displaying a poorly delimited cytoplasm and hyperchromatic nucleus which contained eosinophilic macronucleoli...
November 2018: Journal of Clinical and Experimental Dentistry
V Kaplan, C Morales, F Bobadilla, J Fernández, L Segovia, V Vera, I Sanhueza
BACKGROUND AND OBJECTIVE: Cutaneous metastases (CMs) account for 2% of skin tumors and their incidence varies between 0.7% and 9% in patients with cancer. The objective of this study was to describe and analyze the demographic, clinical, and histopathologic characteristics of CM in patients who visited 2 hospitals in the Santiago de Chile metropolitan region. MATERIAL AND METHOD: We performed a retrospective, descriptive, analytical, observational, cross-sectional study...
December 18, 2018: Actas Dermo-sifiliográficas
Laura Carminati, Denise Pinessi, Patrizia Borsotti, Lucia Minoli, Raffaella Giavazzi, Maurizio D'Incalci, Dorina Belotti, Giulia Taraboletti
Trabectedin is a marine-derived anti-neoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Since a favorable microenvironment is a key factor in the progression of cutaneous melanoma, we hypothesized that trabectedin might affect the growth and metastasis of this highly aggressive cancer.This study shows that trabectedin inhibited the subcutaneous growth of the murine melanoma B16-BL6 and K1735-M2...
December 13, 2018: Carcinogenesis
Dario Piazzalunga, Marco Ceresoli, Niccolò Allievi, Simone Ribero, Pietro Quaglino, Sara Di Lorenzo, Bartolo Corradino, Luca Giovanni Campana, Simone Mocellin, Carlo Riccardo Rossi
BACKGROUND: The indication to sentinel node biopsy (SNB) for thin melanomas (Breslow <1 mm) is still subject to controversies. The aim of this paper is to review all SNB performed for thin melanoma and to analyze factors related to lymphatic metastasis. Moreover, the diagnostic performance of the 5th, 6th, 7th and 8th AJCC classifications for cutaneous melanoma were investigated. METHODS: All sentinel node biopsies performed for thin melanomas were selected from a multicentre prospectively-collected database...
December 1, 2018: European Journal of Surgical Oncology
J M Mor, K R Koch, V Kakkassery, C Cursiefen, L M Heindl
BACKGROUND: Benign iridal tumors rarely necessitate a therapeutic intervention. In contrast, malignant tumors of the iris can threaten the patient's life and eyesight and require early treatment to prevent the development of metastases. OBJECTIVE: Presentation of current treatment options for iridal tumors with special emphasis on iridal melanoma. METHODS: This article gives an overview of the current literature based on a PubMed search as well as own clinical experience...
December 4, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Zacharie Segaoula, Aline Primot, Frederic Lepretre, Benoit Hedan, Emmanuel Bouchaert, Kevin Minier, Laurent Marescaux, François Serres, Sylvie Galiègue-Zouitina, Catherine André, Bruno Quesnel, Xavier Thuru, Dominique Tierny
BACKGROUND: Metastatic melanoma is one of the most aggressive forms of cancer in humans. Among its types, mucosal melanomas represent one of the most highly metastatic and aggressive forms, with a very poor prognosis. Because they are rare in Caucasian individuals, unlike cutaneous melanomas, there has been fewer epidemiological, clinical and genetic evaluation of mucosal melanomas. Moreover, the lack of predictive models fully reproducing the pathogenesis and molecular alterations of mucosal melanoma makes its treatment challenging...
December 4, 2018: BMC Cancer
Yong Zhang, Xiaomin Fu, Yalong Qi, Quanli Gao
AIM: To investigate the characteristics and prognosis of melanoma in a Chinese population. MATERIALS & METHODS:  Total of 162 advanced melanoma patients were analyzed retrospectively. Kaplan-Meier method and Log rank test were used for survival analysis. RESULTS: The median progression-free survival of mucosal and cutaneous melanoma patients was 13 versus 8 months (p = 0.005), 14 versus 10 months in immunotherapy group (p = 0.022), 6 versus 4 months in chemotherapy group (p = 0...
December 4, 2018: Immunotherapy
Rachel Mirsky, Giselle Prado, Ryan Svoboda, Alex Glazer, Darrell Rigel
Importance: The 31 gene-expression profiling test (31-GEP) has been shown to provide useful prognostic information in patients with cutaneous melanoma. The test dichotomizes patients into lower risk (Class 1) or higher risk (Class 2) for melanoma metastasis. Previous studies have demonstrated the clinical utility of the test in impacting dermatologists’ management decisions. Physician assistants and nurse practitioners (PA/NPs) account for a significant portion of dermatologic providers. The impact of a 31-GEP assay on clinical management has not been evaluated in this group...
November 1, 2018: Journal of Drugs in Dermatology: JDD
Mattia Riefolo, Elisa Porcellini, Emi Dika, Elisabetta Broseghini, Manuela Ferracin
The incidence of cutaneous melanoma (CM) has increased in the past few decades. The biology of melanoma is characterized by a complex interaction between genetic, environmental and phenotypic factors. A greater understanding of the molecular mechanisms that promote melanoma cell growth and dissemination is crucial to improve diagnosis, prognostication, and treatment of CM. Both small and long non-coding RNAs (ncRNAs) have been identified to play a role in melanoma biology; microRNA and long ncRNA expression is altered in transformed melanocytes and this in turn has functional effects on cell proliferation, apoptosis, invasion, metastasis, and immune response...
November 30, 2018: Molecular Oncology
John D Strickley, Alfred Bennett Jenson, Jae Yeon Jung
Although rare, cutaneous metastases portend a poor prognosis and are often an indicator of widespread disease. Breast cancer and melanoma are the most common types of cancer that are associated with spread to and within the skin; however, other malignancies, such as lung, colon, head and neck, and hematologic, have been described with a degree of relative frequency. A variety of clinical appearances and syndromes of cutaneous metastases are presented and described in this article. Possible treatment options, including skin-directed therapies and immunotherapies, are also discussed...
February 2019: Hematology/oncology Clinics of North America
Carolina Cubillos-Zapata, Miguel Ángel Martínez-García, Francisco Campos-Rodríguez, Manuel Sánchez de la Torre, Eduardo Nagore, Antonio Martorell-Calatayud, Luis Hernández Blasco, Eusebi Chiner Vives, Jorge Abad-Capa, Josep María Montserrat, Valentín Cabriada-Nuño, Irene Cano-Pumarega, Jaime Corral-Peñafiel, Trinidad Diaz-Cambriles, Olga Mediano, María Somoza-González, Joan Dalmau-Arias, Isaac Almendros, Ramón Farré, Eduardo López-Collazo, David Gozal, Francisco García-Río
Obstructive sleep apnea (OSA) up-regulates the programmed cell death-1 receptor and its ligand (PD-L1) pathway, potentially compromising immunosurveillance. We compared circulating levels of soluble PD-L1 (sPD-L1) in patients with cutaneous melanoma (CM) according to the presence and severity of OSA, and evaluated relationships with tumour aggressiveness and invasiveness.In a multicenter observational study, 360 patients with CM underwent sleep studies, and serum sPD-L1 levels were assayed by ELISA. CM aggressiveness indices included mitotic rate, Breslow index, tumour ulceration, Clark level and tumour stage, and sentinel lymph node (SLN) metastasis was recorded as a marker of invasiveness...
November 28, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Yan Hu, Qi Wang, Xiao-Hong Zhu
Melanoma develops from pigment-producing melanocytes in the epidermis, and is the most common type of skin cancer. Because of the lack of effective therapies, the median survival of patients developing metastatic melanoma is less the 1 year. In this paper, we studied the oncogenic role of miR-135b in melanoma cells. We compared the miR-135b levels in 20 melanoma tissues in reference to their corresponding nontumor regions. Next, we studied the impact of miR-135b or its inhibitor on cell proliferation, migration, or apoptosis in either primary melanocytes or the melanoma cell line, respectively...
November 21, 2018: Melanoma Research
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