Jessica Lee, David Currow, Melanie Lovell, Jane L Phillips, Andrew McLachlan, Megan Ritchie, Linda Brown, Belinda Fazekas, Rajesh Aggarwal, Davinia Seah, Caitlin Sheehan, Richard Chye, Beverly Noble, Nikki McCaffrey, Ghauri Aggarwal, Rachel George, Marian Kow, Chadi Ayoub, Anthony Linton, Christine Sanderson, Dipti Mittal, Angela Rao, Grace Prael, Katalin Urban, Priyanka Vandersman, Meera Agar
INTRODUCTION: Many patients experience unrelieved neuropathic cancer-related pain. Most current analgesic therapies have psychoactive side effects, lack efficacy data for this indication and have potential medication-related harms. The local anaesthetic lidocaine (lignocaine) has the potential to help manage neuropathic cancer-related pain when administered as an extended, continuous subcutaneous infusion. Data support lidocaine as a promising, safe agent in this setting, warranting further evaluation in robust, randomised controlled trials...
February 21, 2023: BMJ Open