Sahar Masoumeh Ghorbanpour, Claire Richards, Dillan Pienaar, Kimberly Sesperez, Hamidreza Aboulkheyr Es, Valentina N Nikolic, Natasa Karadzov Orlic, Zeljko Mikovic, Milan Stefanovic, Zoran Cakic, Abdelrahim Alqudah, Louise Cole, Catherine Gorrie, Kristine McGrath, Mary M Kavurma, Majid Ebrahimi Warkiani, Lana McClements
Preeclampsia is a pregnancy-specific cardiovascular disorder, involving significant maternal endothelial dysfunction. Although inappropriate placentation due to aberrant angiogenesis, inflammation and shallow trophoblast invasion are the root causes of preeclampsia, pathogenic mechanisms are poorly understood, particularly in early pregnancy. Here, we first confirm the abnormal expression of important vascular and inflammatory proteins, FK506-binding protein-like (FKBPL) and galectin-3 (Gal-3), in human plasma and placental tissues from women with preeclampsia and normotensive controls...
January 18, 2023: Cellular and Molecular Life Sciences: CMLS